======= SMC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMC3
  * **<color #00a2e8>Official Name</color>**: structural maintenance of chromosomes 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9126|9126]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UQE7|Q9UQE7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606062|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SMC hinge|
|SMC N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear meiotic cohesin complex|
|modulation by host of viral release from host cell|
|mediator complex binding|
|positive regulation by host of viral release from host cell|
|negative regulation of DNA endoreduplication|
|meiotic cohesin complex|
|regulation of DNA endoreduplication|
|cohesin complex|
|lateral element|
|positive regulation of viral release from host cell|
|positive regulation by host of viral process|
|dynein complex binding|
|regulation of mitotic spindle assembly|
|negative regulation of DNA-dependent DNA replication|
|mitotic spindle pole|
|modulation by host of viral process|
|regulation of spindle assembly|
|regulation of viral release from host cell|
|beta-tubulin binding|
|regulation of mitotic spindle organization|
|negative regulation of DNA replication|
|regulation of spindle organization|
|sister chromatid cohesion|
|regulation of DNA-dependent DNA replication|
|chromosome, centromeric region|
|positive regulation of viral life cycle|
|microtubule motor activity|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|basement membrane|
|positive regulation of viral process|
|regulation of DNA replication|
|nuclear matrix|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|chromatin|
|chromosome|
|stem cell population maintenance|
|maintenance of cell number|
|sister chromatid segregation|
|regulation of viral life cycle|
|modification of morphology or physiology of other organism|
|regulation of mitotic nuclear division|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|regulation of viral process|
|nuclear chromosome segregation|
|regulation of organelle assembly|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of microtubule-based process|
|meiotic cell cycle|
|chromosome segregation|
|negative regulation of cell cycle process|
|chromatin binding|
|protein heterodimerization activity|
|cell division|
|DNA repair|
|positive regulation of multi-organism process|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|DNA metabolic process|
|regulation of cell cycle process|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|cell cycle process|
|chromosome organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.17|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.97|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.82|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.79|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.7|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.73|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.73|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.81|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|2.17|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|2.24|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prpf8|PRPF8]]|0.412|
|[[:human genes:p:psma6|PSMA6]]|0.406|
|[[:human genes:s:stil|STIL]]|0.405|
|[[:human genes:u:upf1|UPF1]]|0.404|
|[[:human genes:c:cdca3|CDCA3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 652/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|26/28|
|bone|25/25|
|breast|29/33|
|central nervous system|51/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|13/15|
|kidney|15/21|
|liver|19/20|
|lung|65/75|
|lymphocyte|13/14|
|ovary|21/26|
|pancreas|22/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|7/7|
|thyroid|0/2|
|upper aerodigestive|19/22|
|urinary tract|24/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 188
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMC3 Expression in NALM6 Cells: 6.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>