======= SMEK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP4R3A
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 4 regulatory subunit 3A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55671|55671]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6IN85|Q6IN85]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMEK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMEK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610351|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SMK-1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule organizing center|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-3.31|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-3.01|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.57|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.27|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.24|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.17|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.15|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.04|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.89|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.87|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.81|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.71|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.05|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.07|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.3|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.34|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.44|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.46|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.73|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.41|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|4.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppp4c|PPP4C]]|0.438|
|[[:human genes:k:kctd5|KCTD5]]|0.41|
|[[:human genes:n:n6amt1|N6AMT1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9923
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMEK1 Expression in NALM6 Cells: 7.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>