======= SMPD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMPD3
  * **<color #00a2e8>Official Name</color>**: sphingomyelin phosphodiesterase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55512|55512]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NY59|Q9NY59]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMPD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMPD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605777|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. {ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Exo endo phos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polysaccharide transport|
|neutral sphingomyelin phosphodiesterase activity|
|polysaccharide localization|
|cellular response to redox state|
|negative regulation of hyaluronan biosynthetic process|
|cellular response to magnesium ion|
|dentinogenesis|
|sphingomyelin catabolic process|
|sphingomyelin phosphodiesterase activity|
|regulation of hyaluronan biosynthetic process|
|G1 to G0 transition|
|positive regulation of sphingolipid biosynthetic process|
|cellular response to oxidised low-density lipoprotein particle stimulus|
|positive regulation of ceramide biosynthetic process|
|sphingolipid mediated signaling pathway|
|sphingomyelin metabolic process|
|response to redox state|
|positive regulation of exosomal secretion|
|regulation of membrane lipid metabolic process|
|regulation of ceramide biosynthetic process|
|regulation of sphingolipid biosynthetic process|
|phospholipase activity|
|regulation of exosomal secretion|
|extracellular matrix assembly|
|response to magnesium ion|
|chondrocyte development involved in endochondral bone morphogenesis|
|response to lipoprotein particle|
|replacement ossification|
|endochondral ossification|
|Golgi cis cisterna|
|cellular response to lipoprotein particle stimulus|
|chondrocyte differentiation involved in endochondral bone morphogenesis|
|sphingolipid catabolic process|
|platelet-derived growth factor receptor signaling pathway|
|membrane lipid catabolic process|
|phospholipid catabolic process|
|regulation of polysaccharide biosynthetic process|
|protein kinase B signaling|
|lung alveolus development|
|chondrocyte development|
|regulation of polysaccharide metabolic process|
|bone growth|
|cartilage development involved in endochondral bone morphogenesis|
|negative regulation of carbohydrate metabolic process|
|bone mineralization|
|positive regulation of mitotic nuclear division|
|peptide hormone secretion|
|glycosphingolipid metabolic process|
|collagen metabolic process|
|positive regulation of nuclear division|
|regulation of cartilage development|
|cellular response to hydrogen peroxide|
|endochondral bone morphogenesis|
|hormone secretion|
|carbohydrate transport|
|positive regulation of lipid biosynthetic process|
|hormone transport|
|chondrocyte differentiation|
|odontogenesis of dentin-containing tooth|
|multicellular organism growth|
|ceramide metabolic process|
|positive regulation of smooth muscle cell proliferation|
|hematopoietic progenitor cell differentiation|
|positive regulation of exocytosis|
|BMP signaling pathway|
|negative regulation of small molecule metabolic process|
|biomineralization|
|biomineral tissue development|
|regulation of carbohydrate biosynthetic process|
|organ growth|
|response to BMP|
|cellular response to BMP stimulus|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|DNA biosynthetic process|
|bone morphogenesis|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|odontogenesis|
|organophosphate catabolic process|
|cellular response to reactive oxygen species|
|regulation of smooth muscle cell proliferation|
|positive regulation of lipid metabolic process|
|mitotic nuclear division|
|positive regulation of cellular amide metabolic process|
|positive regulation of mitotic cell cycle|
|sphingolipid metabolic process|
|regulation of mitotic nuclear division|
|lung development|
|signal release|
|cartilage development|
|respiratory tube development|
|peptide secretion|
|regulation of lipid biosynthetic process|
|regulation of nuclear division|
|cellular response to metal ion|
|ammonium ion metabolic process|
|response to reactive oxygen species|
|cellular lipid catabolic process|
|respiratory system development|
|regulation of leukocyte migration|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|membrane lipid metabolic process|
|regulation of carbohydrate metabolic process|
|cellular response to toxic substance|
|cellular response to inorganic substance|
|regulation of exocytosis|
|connective tissue development|
|skeletal system morphogenesis|
|cellular response to tumor necrosis factor|
|cellular response to oxidative stress|
|ossification|
|response to tumor necrosis factor|
|nuclear division|
|positive regulation of cell cycle process|
|lipid catabolic process|
|response to antibiotic|
|organelle fission|
|cellular response to peptide|
|protein homooligomerization|
|extracellular matrix organization|
|response to metal ion|
|phospholipid metabolic process|
|positive regulation of cell cycle|
|response to oxidative stress|
|extracellular structure organization|
|developmental growth|
|growth|
|regulation of lipid metabolic process|
|positive regulation of secretion by cell|
|regulation of cellular amide metabolic process|
|cellular response to drug|
|regulation of small molecule metabolic process|
|positive regulation of secretion|
|response to peptide|
|skeletal system development|
|cellular response to growth factor stimulus|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|response to growth factor|
|regulation of hormone levels|
|response to inorganic substance|
|regulation of vesicle-mediated transport|
|hemopoiesis|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|hematopoietic or lymphoid organ development|
|Golgi membrane|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|immune system development|
|cellular response to nitrogen compound|
|mitotic cell cycle|
|enzyme linked receptor protein signaling pathway|
|DNA metabolic process|
|regulation of secretion by cell|
|regulation of cell cycle process|
|cellular amide metabolic process|
|regulation of secretion|
|tube development|
|regulation of cell migration|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cell cycle process|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|response to drug|
|carbohydrate derivative metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|cell-cell signaling|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|cell cycle|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|peptide transport|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|amide transport|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|cell development|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.98|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3528
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMPD3 Expression in NALM6 Cells: 1.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>