======= SNAI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNAI1
  * **<color #00a2e8>Official Name</color>**: snail family transcriptional repressor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6615|6615]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95863|O95863]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNAI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNAI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604238|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. {ECO:0000250|UniProtKB:Q02085, ECO:0000269|PubMed:10655587, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21952048}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cell differentiation involved in embryonic placenta development|
|regulation of cell differentiation involved in embryonic placenta development|
|negative regulation of vitamin D biosynthetic process|
|negative regulation of vitamin metabolic process|
|regulation of vitamin D biosynthetic process|
|Notch signaling involved in heart development|
|trophoblast giant cell differentiation|
|epithelial to mesenchymal transition involved in endocardial cushion formation|
|regulation of vitamin metabolic process|
|pericentric heterochromatin|
|negative regulation of DNA damage response, signal transduction by p53 class mediator|
|heterochromatin organization|
|endocardial cushion formation|
|left/right pattern formation|
|regulation of bicellular tight junction assembly|
|negative regulation of steroid biosynthetic process|
|cell surface receptor signaling pathway involved in heart development|
|hair follicle morphogenesis|
|negative regulation of steroid metabolic process|
|cell differentiation involved in embryonic placenta development|
|negative regulation of embryonic development|
|aortic valve morphogenesis|
|cardiac epithelial to mesenchymal transition|
|epidermis morphogenesis|
|cartilage morphogenesis|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|negative regulation of signal transduction by p53 class mediator|
|aortic valve development|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|endocardial cushion morphogenesis|
|semi-lunar valve development|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|endocardial cushion development|
|positive regulation of epithelial to mesenchymal transition|
|negative regulation of lipid biosynthetic process|
|E-box binding|
|mesenchyme morphogenesis|
|heart valve morphogenesis|
|negative regulation of reproductive process|
|heart valve development|
|mesoderm formation|
|mesoderm morphogenesis|
|epithelial to mesenchymal transition|
|hair follicle development|
|skin epidermis development|
|molting cycle process|
|hair cycle process|
|negative regulation of response to DNA damage stimulus|
|negative regulation of lipid metabolic process|
|regulation of epithelial to mesenchymal transition|
|embryonic placenta development|
|regulation of steroid biosynthetic process|
|regulation of cell junction assembly|
|roof of mouth development|
|negative regulation of small molecule metabolic process|
|molting cycle|
|hair cycle|
|kinase binding|
|negative regulation of intrinsic apoptotic signaling pathway|
|formation of primary germ layer|
|regulation of steroid metabolic process|
|mesoderm development|
|Notch signaling pathway|
|osteoblast differentiation|
|regulation of embryonic development|
|placenta development|
|mesenchymal cell differentiation|
|gastrulation|
|regulation of reproductive process|
|regulation of intrinsic apoptotic signaling pathway|
|cartilage development|
|regulation of signal transduction by p53 class mediator|
|regulation of lipid biosynthetic process|
|regulation of response to DNA damage stimulus|
|mesenchyme development|
|connective tissue development|
|negative regulation of apoptotic signaling pathway|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|heart morphogenesis|
|ossification|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regionalization|
|in utero embryonic development|
|skin development|
|regulation of lipid metabolic process|
|regulation of apoptotic signaling pathway|
|epidermis development|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|skeletal system development|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|positive regulation of cell motility|
|heart development|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|chromatin organization|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|chromosome organization|
|cell motility|
|localization of cell|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.87|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.78|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11211
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNAI1 Expression in NALM6 Cells: -0.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>