======= SNIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNIP1
  * **<color #00a2e8>Official Name</color>**: Smad nuclear interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79753|79753]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TAD8|Q8TAD8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608241|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:11567019, ECO:0000269|PubMed:15378006, ECO:0000269|PubMed:18632581, ECO:0000269|PubMed:18794151}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FHA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|production of miRNAs involved in gene silencing by miRNA|
|dsRNA processing|
|production of small RNA involved in gene silencing by RNA|
|gene silencing by miRNA|
|U2-type precatalytic spliceosome|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|I-kappaB kinase/NF-kappaB signaling|
|gene silencing by RNA|
|gene silencing|
|mRNA binding|
|regulation of gene expression, epigenetic|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|intracellular signal transduction|
|negative regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.75|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.73|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.7|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.71|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.75|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.78|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.9|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.97|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.06|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.09|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ccna2|CCNA2]]|0.518|
|[[:human genes:h:hivep3|HIVEP3]]|0.511|
|[[:human genes:i:ik|IK]]|0.497|
|[[:human genes:n:nupl1|NUPL1]]|0.494|
|[[:human genes:t:tspy8|TSPY8]]|0.486|
|[[:human genes:p:polr2j3|POLR2J3]]|0.479|
|[[:human genes:r:ranbp2|RANBP2]]|0.478|
|[[:human genes:t:tceb3c|TCEB3C]]|0.477|
|[[:human genes:d:dtl|DTL]]|0.474|
|[[:human genes:o:orc6|ORC6]]|0.474|
|[[:human genes:n:narfl|NARFL]]|0.471|
|[[:human genes:p:psmb4|PSMB4]]|0.47|
|[[:human genes:l:lrr1|LRR1]]|0.466|
|[[:human genes:p:polr2d|POLR2D]]|0.465|
|[[:human genes:d:dock6|DOCK6]]|0.465|
|[[:human genes:r:rps12|RPS12]]|0.464|
|[[:human genes:k:kif3c|KIF3C]]|0.461|
|[[:human genes:s:supt5h|SUPT5H]]|0.459|
|[[:human genes:n:npipb5|NPIPB5]]|0.457|
|[[:human genes:c:cln6|CLN6]]|0.457|
|[[:human genes:v:vasn|VASN]]|0.454|
|[[:human genes:s:sf3a1|SF3A1]]|0.45|
|[[:human genes:p:prpf19|PRPF19]]|0.447|
|[[:human genes:w:wdr75|WDR75]]|0.447|
|[[:human genes:t:ticrr|TICRR]]|0.446|
|[[:human genes:h:hap1|HAP1]]|0.443|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.443|
|[[:human genes:p:psma6|PSMA6]]|0.442|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.44|
|[[:human genes:p:pan3|PAN3]]|0.438|
|[[:human genes:d:disp2|DISP2]]|0.438|
|[[:human genes:c:cbwd5|CBWD5]]|0.438|
|[[:human genes:c:chd4|CHD4]]|0.437|
|[[:human genes:u:utp20|UTP20]]|0.437|
|[[:human genes:t:tfip11|TFIP11]]|0.437|
|[[:human genes:x:xylt2|XYLT2]]|0.437|
|[[:human genes:r:rnf113a|RNF113A]]|0.436|
|[[:human genes:r:rpl35|RPL35]]|0.435|
|[[:human genes:a:aamp|AAMP]]|0.435|
|[[:human genes:s:slc6a17|SLC6A17]]|0.435|
|[[:human genes:d:ddtl|DDTL]]|0.434|
|[[:human genes:t:tyms|TYMS]]|0.434|
|[[:human genes:e:exd1|EXD1]]|0.434|
|[[:human genes:u:utp3|UTP3]]|0.433|
|[[:human genes:p:polr2a|POLR2A]]|0.433|
|[[:human genes:r:rrp7a|RRP7A]]|0.432|
|[[:human genes:a:ankle2|ANKLE2]]|0.432|
|[[:human genes:v:vps28|VPS28]]|0.43|
|[[:human genes:r:rbm39|RBM39]]|0.43|
|[[:human genes:a:aatf|AATF]]|0.43|
|[[:human genes:s:sec13|SEC13]]|0.429|
|[[:human genes:p:prim1|PRIM1]]|0.429|
|[[:human genes:o:or10g3|OR10G3]]|0.428|
|[[:human genes:a:akirin2|AKIRIN2]]|0.428|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.427|
|[[:human genes:s:supt6h|SUPT6H]]|0.426|
|[[:human genes:n:nop16|NOP16]]|0.426|
|[[:human genes:t:tsg101|TSG101]]|0.426|
|[[:human genes:c:copa|COPA]]|0.425|
|[[:human genes:k:krt78|KRT78]]|0.425|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.424|
|[[:human genes:s:slc4a1|SLC4A1]]|0.424|
|[[:human genes:p:pola1|POLA1]]|0.423|
|[[:human genes:p:psmd1|PSMD1]]|0.423|
|[[:human genes:n:nol10|NOL10]]|0.42|
|[[:human genes:k:krt5|KRT5]]|0.419|
|[[:human genes:c:cgb2|CGB2]]|0.418|
|[[:human genes:c:copz1|COPZ1]]|0.418|
|[[:human genes:c:cbwd3|CBWD3]]|0.418|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.418|
|[[:human genes:c:copg1|COPG1]]|0.417|
|[[:human genes:s:sult2b1|SULT2B1]]|0.417|
|[[:human genes:o:orc1|ORC1]]|0.417|
|[[:human genes:t:twistnb|TWISTNB]]|0.416|
|[[:human genes:e:exosc6|EXOSC6]]|0.416|
|[[:human genes:n:nsf|NSF]]|0.414|
|[[:human genes:z:znf541|ZNF541]]|0.413|
|[[:human genes:t:tpx2|TPX2]]|0.411|
|[[:human genes:s:slc38a7|SLC38A7]]|0.411|
|[[:human genes:p:psmd11|PSMD11]]|0.411|
|[[:human genes:n:napa|NAPA]]|0.41|
|[[:human genes:z:zfand5|ZFAND5]]|0.41|
|[[:human genes:e:exosc9|EXOSC9]]|0.41|
|[[:human genes:r:rffl|RFFL]]|0.41|
|[[:human genes:c:cep192|CEP192]]|0.409|
|[[:human genes:r:rrn3|RRN3]]|0.408|
|[[:human genes:p:psmc2|PSMC2]]|0.408|
|[[:human genes:m:mtch2|MTCH2]]|0.408|
|[[:human genes:c:cdc45|CDC45]]|0.408|
|[[:human genes:a:aqr|AQR]]|0.407|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.407|
|[[:human genes:m:med14|MED14]]|0.405|
|[[:human genes:d:dimt1|DIMT1]]|0.404|
|[[:human genes:r:rps2|RPS2]]|0.403|
|[[:human genes:s:smtn|SMTN]]|0.403|
|[[:human genes:g:gprin2|GPRIN2]]|0.403|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.403|
|[[:human genes:n:nup160|NUP160]]|0.402|
|[[:human genes:p:psmd14|PSMD14]]|0.402|
|[[:human genes:c:chmp4b|CHMP4B]]|0.401|
|[[:human genes:c:cbwd6|CBWD6]]|0.401|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.401|
|[[:human genes:t:terf2|TERF2]]|0.401|
|[[:human genes:p:paf1|PAF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 328/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|12/28|
|blood|12/28|
|bone|9/26|
|breast|18/33|
|central nervous system|24/56|
|cervix|0/4|
|colorectal|9/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|10/21|
|liver|5/20|
|lung|34/75|
|lymphocyte|12/16|
|ovary|6/26|
|pancreas|8/24|
|peripheral nervous system|10/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|10/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|10/22|
|urinary tract|11/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 991
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNIP1 Expression in NALM6 Cells: 5.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>