======= SOX8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOX8
  * **<color #00a2e8>Official Name</color>**: SRY-box transcription factor 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=30812|30812]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P57073|P57073]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOX8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOX8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605923|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the cognitive disability found in an alpha-thalassemia-related syndrome (ART-16). This protein is also highly expressed in the majority of human hepatocellular carcinomas and promotes cellular proliferation and enhanced tumor growth. [provided by RefSeq, Jul 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sox N|
|HMG box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retinal rod cell differentiation|
|renal vesicle induction|
|astrocyte fate commitment|
|metanephric nephron tubule formation|
|metanephric tubule formation|
|ureter morphogenesis|
|metanephric nephron tubule morphogenesis|
|negative regulation of photoreceptor cell differentiation|
|regulation of photoreceptor cell differentiation|
|positive regulation of osteoblast proliferation|
|metanephric tubule morphogenesis|
|enteric nervous system development|
|glial cell fate commitment|
|Sertoli cell development|
|metanephric nephron tubule development|
|ureter development|
|nephron tubule formation|
|metanephric nephron epithelium development|
|positive regulation of branching involved in ureteric bud morphogenesis|
|metanephric tubule development|
|camera-type eye photoreceptor cell differentiation|
|Sertoli cell differentiation|
|metanephric nephron morphogenesis|
|positive regulation of mesonephros development|
|metanephric epithelium development|
|regulation of branching involved in ureteric bud morphogenesis|
|regulation of osteoblast proliferation|
|nuclear transcription factor complex|
|regulation of mesonephros development|
|negative regulation of myoblast differentiation|
|developmental induction|
|metanephros morphogenesis|
|metanephric nephron development|
|positive regulation of morphogenesis of an epithelium|
|RNA polymerase II core promoter sequence-specific DNA binding|
|adipose tissue development|
|positive regulation of kidney development|
|autonomic nervous system development|
|eye photoreceptor cell differentiation|
|retina morphogenesis in camera-type eye|
|skeletal muscle cell differentiation|
|astrocyte differentiation|
|regulation of myoblast differentiation|
|neural crest cell migration|
|regulation of kidney development|
|regulation of morphogenesis of a branching structure|
|neural retina development|
|photoreceptor cell differentiation|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|oligodendrocyte differentiation|
|positive regulation of gliogenesis|
|peripheral nervous system development|
|nephron tubule development|
|neural crest cell development|
|renal tubule development|
|positive regulation of animal organ morphogenesis|
|stem cell development|
|metanephros development|
|mesenchymal cell development|
|kidney morphogenesis|
|neural crest cell differentiation|
|nephron epithelium development|
|fat cell differentiation|
|camera-type eye morphogenesis|
|regulation of gliogenesis|
|embryonic epithelial tube formation|
|skeletal muscle tissue development|
|nephron development|
|osteoblast differentiation|
|kidney epithelium development|
|epithelial tube formation|
|skeletal muscle organ development|
|male gonad development|
|development of primary male sexual characteristics|
|retina development in camera-type eye|
|morphogenesis of embryonic epithelium|
|tube formation|
|eye morphogenesis|
|male sex differentiation|
|mesenchymal cell differentiation|
|stem cell differentiation|
|cell maturation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|glial cell differentiation|
|ameboidal-type cell migration|
|regulation of morphogenesis of an epithelium|
|epithelial cell development|
|gonad development|
|gliogenesis|
|development of primary sexual characteristics|
|mesenchyme development|
|connective tissue development|
|negative regulation of neuron differentiation|
|developmental maturation|
|cell fate commitment|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|ossification|
|sex differentiation|
|kidney development|
|renal system development|
|striated muscle tissue development|
|negative regulation of neurogenesis|
|muscle organ development|
|muscle tissue development|
|epithelial tube morphogenesis|
|negative regulation of nervous system development|
|camera-type eye development|
|urogenital system development|
|transcription factor binding|
|negative regulation of cell development|
|eye development|
|visual system development|
|sensory system development|
|in utero embryonic development|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of neurogenesis|
|muscle structure development|
|protein heterodimerization activity|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|spermatogenesis|
|sensory organ development|
|male gamete generation|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|gamete generation|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|multi-organism reproductive process|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.77|
|[[:results:exp539|42°C R08 exp539]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zbp1|ZBP1]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10425
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOX8 Expression in NALM6 Cells: -3.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>