======= SPCS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPCS2
  * **<color #00a2e8>Official Name</color>**: signal peptidase complex subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9789|9789]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15005|Q15005]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPCS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPCS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619411|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SPC25|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|signal peptidase complex|
|signal peptide processing|
|peptidase activity|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|protein localization to endoplasmic reticulum|
|protein processing|
|protein maturation|
|protein targeting|
|establishment of protein localization to organelle|
|peptide metabolic process|
|protein localization to organelle|
|cellular amide metabolic process|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|proteolysis|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|1.8|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.85|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.87|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eprs|EPRS]]|0.543|
|[[:human genes:h:hspd1|HSPD1]]|0.536|
|[[:human genes:h:hars|HARS]]|0.513|
|[[:human genes:r:rnmt|RNMT]]|0.501|
|[[:human genes:g:gmppb|GMPPB]]|0.492|
|[[:human genes:m:med16|MED16]]|0.48|
|[[:human genes:c:cep350|CEP350]]|0.475|
|[[:human genes:n:nars|NARS]]|0.473|
|[[:human genes:p:pelo|PELO]]|0.471|
|[[:human genes:c:csnk2b|CSNK2B]]|0.467|
|[[:human genes:d:dad1|DAD1]]|0.467|
|[[:human genes:a:alg2|ALG2]]|0.467|
|[[:human genes:m:mad2l1|MAD2L1]]|0.465|
|[[:human genes:d:dpagt1|DPAGT1]]|0.464|
|[[:human genes:d:ddost|DDOST]]|0.464|
|[[:human genes:m:meaf6|MEAF6]]|0.463|
|[[:human genes:t:thg1l|THG1L]]|0.462|
|[[:human genes:s:slc35b1|SLC35B1]]|0.462|
|[[:human genes:e:eif4e|EIF4E]]|0.46|
|[[:human genes:m:mars|MARS]]|0.459|
|[[:human genes:r:rpn1|RPN1]]|0.456|
|[[:human genes:s:seh1l|SEH1L]]|0.456|
|[[:human genes:p:pam16|PAM16]]|0.454|
|[[:human genes:t:tti2|TTI2]]|0.45|
|[[:human genes:y:yars|YARS]]|0.449|
|[[:human genes:s:srp72|SRP72]]|0.448|
|[[:human genes:r:rtcb|RTCB]]|0.448|
|[[:human genes:n:nae1|NAE1]]|0.447|
|[[:human genes:c:ccdc101|CCDC101]]|0.445|
|[[:human genes:d:dhdds|DHDDS]]|0.443|
|[[:human genes:p:pmm2|PMM2]]|0.441|
|[[:human genes:p:polr3b|POLR3B]]|0.441|
|[[:human genes:r:rptor|RPTOR]]|0.439|
|[[:human genes:p:polr3h|POLR3H]]|0.436|
|[[:human genes:g:gfpt1|GFPT1]]|0.435|
|[[:human genes:e:eny2|ENY2]]|0.434|
|[[:human genes:s:sec61g|SEC61G]]|0.433|
|[[:human genes:a:aars|AARS]]|0.427|
|[[:human genes:d:ddx20|DDX20]]|0.425|
|[[:human genes:t:tti1|TTI1]]|0.422|
|[[:human genes:a:alg14|ALG14]]|0.42|
|[[:human genes:r:rbm14|RBM14]]|0.418|
|[[:human genes:a:alg1|ALG1]]|0.417|
|[[:human genes:v:vrk1|VRK1]]|0.416|
|[[:human genes:t:tbcd|TBCD]]|0.415|
|[[:human genes:d:dhps|DHPS]]|0.415|
|[[:human genes:o:osgep|OSGEP]]|0.41|
|[[:human genes:r:rpp21|RPP21]]|0.41|
|[[:human genes:u:uap1|UAP1]]|0.408|
|[[:human genes:n:nxt1|NXT1]]|0.406|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.406|
|[[:human genes:o:otud5|OTUD5]]|0.405|
|[[:human genes:t:triap1|TRIAP1]]|0.404|
|[[:human genes:a:alg5|ALG5]]|0.402|
|[[:human genes:a:adsl|ADSL]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 236/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|8/28|
|blood|9/28|
|bone|11/26|
|breast|15/33|
|central nervous system|23/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|8/21|
|liver|9/20|
|lung|17/75|
|lymphocyte|4/16|
|ovary|4/26|
|pancreas|5/24|
|peripheral nervous system|8/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|12/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|7/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2349
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPCS2 Expression in NALM6 Cells: 6.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>