======= SPINT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPINT1
  * **<color #00a2e8>Official Name</color>**: serine peptidase inhibitor, Kunitz type 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6692|6692]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43278|O43278]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPINT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPINT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605123|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kunitz BPTI|
|Ldl recept a|
|MANEC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|branching involved in labyrinthine layer morphogenesis|
|labyrinthine layer morphogenesis|
|negative regulation of neural precursor cell proliferation|
|embryonic placenta morphogenesis|
|placenta blood vessel development|
|positive regulation of glial cell differentiation|
|labyrinthine layer development|
|positive regulation of gliogenesis|
|regulation of glial cell differentiation|
|embryonic placenta development|
|regulation of neural precursor cell proliferation|
|neural tube closure|
|tube closure|
|serine-type endopeptidase inhibitor activity|
|primary neural tube formation|
|cellular response to BMP stimulus|
|response to BMP|
|neural tube formation|
|regulation of gliogenesis|
|embryonic epithelial tube formation|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|placenta development|
|morphogenesis of a branching epithelium|
|neural tube development|
|morphogenesis of a branching structure|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|epithelial tube morphogenesis|
|extracellular matrix organization|
|negative regulation of proteolysis|
|in utero embryonic development|
|extracellular structure organization|
|regulation of endopeptidase activity|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|positive regulation of neurogenesis|
|blood vessel development|
|cellular response to growth factor stimulus|
|vasculature development|
|cardiovascular system development|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cell development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|regulation of neurogenesis|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|embryo development|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|epithelium development|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|generation of neurons|
|extracellular space|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.01|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4483
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPINT1 Expression in NALM6 Cells: 2.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>