======= SPP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPP1
  * **<color #00a2e8>Official Name</color>**: secreted phosphoprotein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6696|6696]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10451|P10451]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/166490|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Osteopontin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of collateral sprouting of intact axon in response to injury|
|negative regulation of collateral sprouting of intact axon in response to injury|
|positive regulation of estradiol secretion|
|regulation of estradiol secretion|
|androgen catabolic process|
|cellular response to testosterone stimulus|
|negative regulation of collateral sprouting|
|negative regulation of axon regeneration|
|negative regulation of neuron projection regeneration|
|hormone catabolic process|
|positive regulation of bone resorption|
|positive regulation of bone remodeling|
|regulation of collateral sprouting|
|decidualization|
|regulation of axon regeneration|
|androgen metabolic process|
|steroid catabolic process|
|extracellular matrix binding|
|regulation of neuron projection regeneration|
|response to vitamin D|
|positive regulation of tissue remodeling|
|maternal placenta development|
|embryo implantation|
|response to testosterone|
|regulation of bone resorption|
|regulation of bone remodeling|
|positive regulation of lipid transport|
|maternal process involved in female pregnancy|
|negative regulation of axonogenesis|
|regulation of tissue remodeling|
|positive regulation of lipid localization|
|negative regulation of response to wounding|
|response to vitamin|
|cellular response to ketone|
|biomineralization|
|biomineral tissue development|
|negative regulation of cell morphogenesis involved in differentiation|
|cell projection|
|negative regulation of developmental growth|
|regulation of lipid transport|
|regulation of extent of cell growth|
|cellular hormone metabolic process|
|osteoblast differentiation|
|positive regulation of hormone secretion|
|integrin binding|
|regulation of lipid localization|
|placenta development|
|negative regulation of neuron projection development|
|regulation of response to wounding|
|cytokine activity|
|female pregnancy|
|negative regulation of cell projection organization|
|regulation of cell size|
|negative regulation of cell growth|
|regulation of axonogenesis|
|response to ketone|
|hormone metabolic process|
|multi-multicellular organism process|
|response to nutrient|
|negative regulation of neuron differentiation|
|negative regulation of growth|
|steroid metabolic process|
|ossification|
|regulation of hormone secretion|
|negative regulation of neurogenesis|
|lipid catabolic process|
|regulation of cell morphogenesis involved in differentiation|
|endoplasmic reticulum lumen|
|negative regulation of nervous system development|
|response to steroid hormone|
|regulation of developmental growth|
|negative regulation of cell development|
|extracellular matrix organization|
|post-translational protein modification|
|negative regulation of response to external stimulus|
|regulation of cellular component size|
|extracellular structure organization|
|positive regulation of secretion by cell|
|regulation of cell growth|
|reproductive structure development|
|reproductive system development|
|positive regulation of secretion|
|organic cyclic compound catabolic process|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|response to nutrient levels|
|inflammatory response|
|regulation of anatomical structure size|
|cellular response to lipid|
|response to extracellular stimulus|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|cellular response to hormone stimulus|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|Golgi apparatus|
|positive regulation of transport|
|multi-organism reproductive process|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|defense response|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|extracellular space|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|organic substance catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.79|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.83|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.93|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18013
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPP1 Expression in NALM6 Cells: 6.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>