======= SPTBN4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPTBN4
  * **<color #00a2e8>Official Name</color>**: spectrin beta, non-erythrocytic 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57731|57731]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H254|Q9H254]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPTBN4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPTBN4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606214|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAMSAP CH|
|PH|
|CH|
|Spectrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell body fiber|
|clustering of voltage-gated sodium channels|
|axon hillock|
|spectrin|
|cytoskeletal anchoring at plasma membrane|
|negative regulation of heart rate|
|neuronal ion channel clustering|
|paranode region of axon|
|node of Ranvier|
|axon initial segment|
|ankyrin binding|
|negative regulation of heart contraction|
|central nervous system projection neuron axonogenesis|
|spectrin binding|
|adult walking behavior|
|walking behavior|
|positive regulation of multicellular organism growth|
|actin filament capping|
|negative regulation of blood circulation|
|central nervous system neuron axonogenesis|
|negative regulation of actin filament depolymerization|
|neuron maturation|
|intercalated disc|
|phosphatase binding|
|regulation of actin filament depolymerization|
|negative regulation of actin filament polymerization|
|transmission of nerve impulse|
|negative regulation of protein depolymerization|
|adherens junction|
|regulation of multicellular organism growth|
|negative regulation of protein polymerization|
|negative regulation of protein complex disassembly|
|maintenance of protein location in cell|
|adult locomotory behavior|
|central nervous system neuron development|
|regulation of protein depolymerization|
|regulation of sodium ion transport|
|cardiac conduction|
|maintenance of location in cell|
|regulation of heart rate|
|PML body|
|structural constituent of cytoskeleton|
|phospholipid binding|
|maintenance of protein location|
|nuclear matrix|
|regulation of protein complex disassembly|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|anatomical structure maturation|
|multicellular organismal signaling|
|regulation of peptidyl-serine phosphorylation|
|negative regulation of cytoskeleton organization|
|adult behavior|
|sensory perception of sound|
|cell maturation|
|maintenance of location|
|regulation of actin filament polymerization|
|sensory perception of mechanical stimulus|
|fertilization|
|positive regulation of developmental growth|
|central nervous system neuron differentiation|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|protein localization to plasma membrane|
|locomotory behavior|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of protein polymerization|
|protein localization to cell periphery|
|developmental maturation|
|regulation of heart contraction|
|positive regulation of growth|
|axon guidance|
|regulation of actin filament organization|
|neuron projection guidance|
|actin binding|
|regulation of blood circulation|
|regulation of developmental growth|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|neuronal cell body|
|axonogenesis|
|MAPK cascade|
|Golgi vesicle transport|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|regulation of protein complex assembly|
|protein localization to membrane|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|regulation of anatomical structure size|
|regulation of cytoskeleton organization|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|behavior|
|regulation of system process|
|neuron projection development|
|regulation of growth|
|regulation of ion transport|
|negative regulation of cellular component organization|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|sexual reproduction|
|membrane organization|
|regulation of cellular component biogenesis|
|sensory perception|
|protein phosphorylation|
|central nervous system development|
|multi-organism reproductive process|
|neuron differentiation|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|intracellular transport|
|generation of neurons|
|movement of cell or subcellular component|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13017
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPTBN4 Expression in NALM6 Cells: 1.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>