======= SRP72 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRP72
  * **<color #00a2e8>Official Name</color>**: signal recognition particle 72
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6731|6731]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O76094|O76094]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRP72&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRP72|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602122|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SRP72|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|signal recognition particle binding|
|signal recognition particle|
|signal recognition particle, endoplasmic reticulum targeting|
|TPR domain binding|
|7S RNA binding|
|ribosome binding|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|protein localization to endoplasmic reticulum|
|protein targeting to membrane|
|establishment of protein localization to membrane|
|protein targeting|
|establishment of protein localization to organelle|
|protein localization to membrane|
|protein localization to organelle|
|intracellular protein transport|
|endoplasmic reticulum|
|response to drug|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp136|MS094 2μM R03 exp136]]|-2.08|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.71|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.72|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.03|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.15|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|3.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rnmt|RNMT]]|0.593|
|[[:human genes:m:mars|MARS]]|0.564|
|[[:human genes:h:hars|HARS]]|0.546|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.539|
|[[:human genes:p:polr3h|POLR3H]]|0.519|
|[[:human genes:d:dpagt1|DPAGT1]]|0.515|
|[[:human genes:s:srp68|SRP68]]|0.512|
|[[:human genes:p:pmm2|PMM2]]|0.51|
|[[:human genes:g:gfpt1|GFPT1]]|0.499|
|[[:human genes:t:tti2|TTI2]]|0.497|
|[[:human genes:s:srp19|SRP19]]|0.493|
|[[:human genes:a:aars|AARS]]|0.485|
|[[:human genes:g:gmppb|GMPPB]]|0.485|
|[[:human genes:t:thg1l|THG1L]]|0.483|
|[[:human genes:m:mad2l1|MAD2L1]]|0.48|
|[[:human genes:p:pam16|PAM16]]|0.477|
|[[:human genes:a:alg2|ALG2]]|0.476|
|[[:human genes:d:dhdds|DHDDS]]|0.476|
|[[:human genes:o:otud5|OTUD5]]|0.475|
|[[:human genes:r:rptor|RPTOR]]|0.472|
|[[:human genes:g:gnb1l|GNB1L]]|0.469|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.468|
|[[:human genes:g:gtf3a|GTF3A]]|0.464|
|[[:human genes:h:hspd1|HSPD1]]|0.464|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.462|
|[[:human genes:c:csnk2b|CSNK2B]]|0.461|
|[[:human genes:r:rbm14|RBM14]]|0.459|
|[[:human genes:p:polr3b|POLR3B]]|0.459|
|[[:human genes:h:hmgb2|HMGB2]]|0.458|
|[[:human genes:o:oraov1|ORAOV1]]|0.457|
|[[:human genes:m:med16|MED16]]|0.457|
|[[:human genes:n:nsmce1|NSMCE1]]|0.457|
|[[:human genes:c:cmtr1|CMTR1]]|0.456|
|[[:human genes:p:pelo|PELO]]|0.453|
|[[:human genes:r:rtcb|RTCB]]|0.451|
|[[:human genes:b:bub3|BUB3]]|0.45|
|[[:human genes:s:spcs2|SPCS2]]|0.448|
|[[:human genes:d:dad1|DAD1]]|0.448|
|[[:human genes:v:vmp1|VMP1]]|0.446|
|[[:human genes:a:alg1|ALG1]]|0.445|
|[[:human genes:m:meaf6|MEAF6]]|0.443|
|[[:human genes:c:cars|CARS]]|0.44|
|[[:human genes:r:rpn1|RPN1]]|0.438|
|[[:human genes:t:tti1|TTI1]]|0.437|
|[[:human genes:c:ccdc101|CCDC101]]|0.437|
|[[:human genes:s:slc35b1|SLC35B1]]|0.437|
|[[:human genes:e:eif4e|EIF4E]]|0.436|
|[[:human genes:l:lsmd1|LSMD1]]|0.435|
|[[:human genes:t:tbca|TBCA]]|0.435|
|[[:human genes:n:nsmce2|NSMCE2]]|0.434|
|[[:human genes:t:tsen54|TSEN54]]|0.43|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.429|
|[[:human genes:c:cct7|CCT7]]|0.426|
|[[:human genes:t:telo2|TELO2]]|0.426|
|[[:human genes:d:ddx20|DDX20]]|0.423|
|[[:human genes:c:cbfb|CBFB]]|0.423|
|[[:human genes:m:mtor|MTOR]]|0.422|
|[[:human genes:t:tsen34|TSEN34]]|0.421|
|[[:human genes:a:alg14|ALG14]]|0.421|
|[[:human genes:m:mapk14|MAPK14]]|0.42|
|[[:human genes:a:alg5|ALG5]]|0.419|
|[[:human genes:u:uap1|UAP1]]|0.416|
|[[:human genes:t:triap1|TRIAP1]]|0.416|
|[[:human genes:n:nars|NARS]]|0.416|
|[[:human genes:s:srprb|SRPRB]]|0.414|
|[[:human genes:v:vrk1|VRK1]]|0.412|
|[[:human genes:u:ube2k|UBE2K]]|0.411|
|[[:human genes:a:atxn10|ATXN10]]|0.408|
|[[:human genes:s:srpr|SRPR]]|0.406|
|[[:human genes:d:dohh|DOHH]]|0.406|
|[[:human genes:p:pisd|PISD]]|0.403|
|[[:human genes:a:alg13|ALG13]]|0.401|
|[[:human genes:t:tbp|TBP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 540/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|21/28|
|blood|18/28|
|bone|14/26|
|breast|19/33|
|central nervous system|42/56|
|cervix|3/4|
|colorectal|14/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|14/16|
|kidney|14/21|
|liver|19/20|
|lung|58/75|
|lymphocyte|10/16|
|ovary|21/26|
|pancreas|18/24|
|peripheral nervous system|10/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|19/24|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|16/22|
|urinary tract|21/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1760
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRP72 Expression in NALM6 Cells: 7.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>