======= SRPRB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRPRB
  * **<color #00a2e8>Official Name</color>**: SRP receptor subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58477|58477]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5M8|Q9Y5M8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRPRB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRPRB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616883|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GTP EFTU|
|SRPRB|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic microtubule|
|IRE1-mediated unfolded protein response|
|endoplasmic reticulum unfolded protein response|
|cellular response to unfolded protein|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|response to topologically incorrect protein|
|response to endoplasmic reticulum stress|
|GTP binding|
|endoplasmic reticulum membrane|
|cellular response to stress|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.12|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.82|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.74|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.86|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.91|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.98|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.09|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:srp68|SRP68]]|0.474|
|[[:human genes:d:dad1|DAD1]]|0.464|
|[[:human genes:a:atxn10|ATXN10]]|0.462|
|[[:human genes:d:dpagt1|DPAGT1]]|0.459|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.457|
|[[:human genes:g:gfpt1|GFPT1]]|0.456|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.455|
|[[:human genes:t:thg1l|THG1L]]|0.454|
|[[:human genes:p:pmm2|PMM2]]|0.45|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.447|
|[[:human genes:p:polr3h|POLR3H]]|0.427|
|[[:human genes:t:trnt1|TRNT1]]|0.427|
|[[:human genes:r:rnmt|RNMT]]|0.42|
|[[:human genes:a:alg1|ALG1]]|0.418|
|[[:human genes:r:rtcb|RTCB]]|0.417|
|[[:human genes:u:uap1|UAP1]]|0.416|
|[[:human genes:s:srp14|SRP14]]|0.415|
|[[:human genes:g:gmppb|GMPPB]]|0.415|
|[[:human genes:s:srp72|SRP72]]|0.414|
|[[:human genes:t:tpi1|TPI1]]|0.412|
|[[:human genes:z:znf259|ZNF259]]|0.41|
|[[:human genes:p:ppcs|PPCS]]|0.408|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.407|
|[[:human genes:v:vezt|VEZT]]|0.405|
|[[:human genes:y:yars|YARS]]|0.403|
|[[:human genes:s:srpr|SRPR]]|0.403|
|[[:human genes:o:oraov1|ORAOV1]]|0.402|
|[[:human genes:w:wdr24|WDR24]]|0.401|
|[[:human genes:f:fbxo11|FBXO11]]|0.4|
|[[:human genes:t:telo2|TELO2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1581
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRPRB Expression in NALM6 Cells: 6.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>