======= SRSF6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRSF6
  * **<color #00a2e8>Official Name</color>**: serine and arginine rich splicing factor 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6431|6431]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13247|Q13247]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRSF6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRSF6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601944|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:22767602, ECO:0000269|PubMed:24440982}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of epithelial cell proliferation involved in lung morphogenesis|
|negative regulation of type B pancreatic cell apoptotic process|
|regulation of epithelial cell proliferation involved in lung morphogenesis|
|negative regulation of keratinocyte differentiation|
|regulation of type B pancreatic cell apoptotic process|
|negative regulation of epidermal cell differentiation|
|pre-mRNA binding|
|alternative mRNA splicing, via spliceosome|
|negative regulation of epidermis development|
|negative regulation of mRNA splicing, via spliceosome|
|negative regulation of RNA splicing|
|negative regulation of mRNA processing|
|mRNA splice site selection|
|mRNA cis splicing, via spliceosome|
|regulation of keratinocyte proliferation|
|negative regulation of epithelial cell differentiation|
|regulation of keratinocyte differentiation|
|negative regulation of epithelial cell apoptotic process|
|spliceosomal complex assembly|
|regulation of epidermal cell differentiation|
|regulation of alternative mRNA splicing, via spliceosome|
|regulation of epithelial cell apoptotic process|
|negative regulation of mRNA metabolic process|
|mRNA 3-end processing|
|positive regulation of animal organ morphogenesis|
|regulation of epidermis development|
|regulation of mRNA splicing, via spliceosome|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|regulation of RNA splicing|
|regulation of mRNA processing|
|regulation of wound healing|
|regulation of epithelial cell differentiation|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|regulation of response to wounding|
|positive regulation of epithelial cell proliferation|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|response to insulin|
|ribonucleoprotein complex assembly|
|nucleobase-containing compound transport|
|ribonucleoprotein complex subunit organization|
|protein-containing complex localization|
|regulation of animal organ morphogenesis|
|nucleocytoplasmic transport|
|nuclear transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|regulation of epithelial cell proliferation|
|response to peptide hormone|
|RNA splicing|
|nuclear speck|
|ribonucleoprotein complex biogenesis|
|response to peptide|
|mRNA processing|
|mRNA metabolic process|
|negative regulation of cell differentiation|
|cellular protein-containing complex assembly|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|intracellular protein transport|
|negative regulation of cell death|
|response to organonitrogen compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|negative regulation of multicellular organismal process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|RNA metabolic process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.73|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-2.41|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.72|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.86|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.86|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.11|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.441|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 37/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|2/25|
|breast|2/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/15|
|kidney|0/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|1/14|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3139
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRSF6 Expression in NALM6 Cells: 8.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>