======= ST3GAL4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ST3GAL4
  * **<color #00a2e8>Official Name</color>**: ST3 beta-galactoside alpha-2,3-sialyltransferase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6484|6484]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q11206|Q11206]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ST3GAL4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ST3GAL4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/104240|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta- 1,4-GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. {ECO:0000250|UniProtKB:Q91Y74, ECO:0000269|PubMed:8611500}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco transf 29|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|monosialoganglioside sialyltransferase activity|
|beta-galactoside (CMP) alpha-2,3-sialyltransferase activity|
|protein sialylation|
|lipid glycosylation|
|sialyltransferase activity|
|oligosaccharide biosynthetic process|
|sialylation|
|keratan sulfate biosynthetic process|
|keratan sulfate metabolic process|
|oligosaccharide metabolic process|
|O-glycan processing|
|glycolipid biosynthetic process|
|Golgi cisterna membrane|
|glycosaminoglycan biosynthetic process|
|mucopolysaccharide metabolic process|
|aminoglycan biosynthetic process|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|protein O-linked glycosylation|
|carbohydrate biosynthetic process|
|membrane lipid biosynthetic process|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|sulfur compound biosynthetic process|
|lipid modification|
|membrane lipid metabolic process|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|cognition|
|glycoprotein biosynthetic process|
|sulfur compound metabolic process|
|glycoprotein metabolic process|
|carbohydrate metabolic process|
|lipid biosynthetic process|
|Golgi membrane|
|carbohydrate derivative biosynthetic process|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|nervous system process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|extracellular region|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9556
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ST3GAL4 Expression in NALM6 Cells: 2.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>