======= STAG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STAG1
  * **<color #00a2e8>Official Name</color>**: stromal antigen 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10274|10274]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WVM7|Q8WVM7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STAG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STAG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604358|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|STAG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cohesin complex|
|regulation of mitotic spindle assembly|
|mitotic spindle pole|
|regulation of spindle assembly|
|regulation of mitotic spindle organization|
|regulation of spindle organization|
|sister chromatid cohesion|
|chromosome, centromeric region|
|nuclear matrix|
|chromatin|
|chromosome|
|sister chromatid segregation|
|regulation of mitotic nuclear division|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|nuclear chromosome segregation|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|chromosome segregation|
|nuclear body|
|chromatin binding|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|cell division|
|regulation of cytoskeleton organization|
|regulation of mitotic cell cycle|
|regulation of cell cycle process|
|regulation of cellular component biogenesis|
|cell cycle process|
|chromosome organization|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|regulation of organelle organization|
|cell cycle|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.24|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.77|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.77|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.72|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.75|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.77|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.77|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.83|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.88|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.89|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.425|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|3/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1796
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STAG1 Expression in NALM6 Cells: 6.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>