======= STOX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STOX1
  * **<color #00a2e8>Official Name</color>**: storkhead box 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=219736|219736]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZVD7|Q6ZVD7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STOX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STOX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609397|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene may function as a DNA binding protein. Mutations in this gene are associated with pre-eclampsia/eclampsia 4 (PEE4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Stork head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of otic vesicle morphogenesis|
|positive regulation of otic vesicle morphogenesis|
|regulation of mitochondrial DNA metabolic process|
|cellular response to nitrosative stress|
|response to nitrosative stress|
|positive regulation of G2/M transition of mitotic cell cycle|
|positive regulation of peptidyl-threonine phosphorylation|
|positive regulation of cell cycle G2/M phase transition|
|positive regulation of morphogenesis of an epithelium|
|positive regulation of cyclin-dependent protein kinase activity|
|positive regulation of embryonic development|
|regulation of peptidyl-threonine phosphorylation|
|regulation of mitochondrial membrane potential|
|positive regulation of mitotic cell cycle phase transition|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|positive regulation of animal organ morphogenesis|
|regulation of response to oxidative stress|
|positive regulation of cell cycle phase transition|
|regulation of cyclin-dependent protein kinase activity|
|positive regulation of peptidyl-serine phosphorylation|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of DNA-templated transcription in response to stress|
|regulation of embryonic development|
|fibrillar center|
|cell cortex|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of mitotic cell cycle|
|positive regulation of protein kinase B signaling|
|regulation of morphogenesis of an epithelium|
|regulation of mitochondrion organization|
|cellular response to hypoxia|
|positive regulation of epithelial cell proliferation|
|inner ear development|
|regulation of G2/M transition of mitotic cell cycle|
|cellular response to decreased oxygen levels|
|regulation of cell cycle G2/M phase transition|
|cellular response to oxygen levels|
|regulation of protein kinase B signaling|
|ear development|
|regulation of animal organ morphogenesis|
|positive regulation of cell cycle process|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of epithelial cell proliferation|
|response to hypoxia|
|regulation of DNA metabolic process|
|response to decreased oxygen levels|
|positive regulation of cell cycle|
|response to oxygen levels|
|regulation of mitotic cell cycle phase transition|
|regulation of membrane potential|
|regulation of cell cycle phase transition|
|centrosome|
|cell division|
|positive regulation of protein kinase activity|
|sensory organ development|
|positive regulation of kinase activity|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|regulation of cell cycle process|
|regulation of protein kinase activity|
|regulation of kinase activity|
|positive regulation of cell population proliferation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of protein modification process|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.72|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18206
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STOX1 Expression in NALM6 Cells: 3.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>