======= STX7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STX7
  * **<color #00a2e8>Official Name</color>**: syntaxin 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8417|8417]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15400|O15400]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STX7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STX7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603217|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Syntaxin|
|SNARE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of receptor localization to synapse|
|tertiary granule|
|positive regulation of protein localization to synapse|
|chloride channel inhibitor activity|
|azurophil granule|
|regulation of receptor localization to synapse|
|positive regulation of T cell mediated cytotoxicity|
|regulation of protein localization to synapse|
|SNAP receptor activity|
|regulation of T cell mediated cytotoxicity|
|immunological synapse|
|SNARE complex|
|positive regulation of T cell mediated immunity|
|syntaxin binding|
|positive regulation of leukocyte mediated cytotoxicity|
|endocytic vesicle|
|vesicle docking|
|SNARE binding|
|positive regulation of cell killing|
|regulation of T cell mediated immunity|
|vesicle fusion|
|endomembrane system|
|organelle membrane fusion|
|regulation of leukocyte mediated cytotoxicity|
|regulation of protein localization to plasma membrane|
|organelle fusion|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|regulation of protein localization to cell periphery|
|recycling endosome|
|synaptic vesicle|
|late endosome|
|membrane fusion|
|positive regulation of leukocyte mediated immunity|
|vesicle|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|early endosome membrane|
|regulation of adaptive immune response|
|organelle localization by membrane tethering|
|membrane docking|
|regulation of protein localization to membrane|
|regulation of leukocyte mediated immunity|
|positive regulation of immune effector process|
|lysosome|
|early endosome|
|endosome|
|lysosomal membrane|
|vesicle organization|
|regulation of immune effector process|
|regulation of cellular protein localization|
|organelle localization|
|perinuclear region of cytoplasm|
|organelle assembly|
|membrane organization|
|positive regulation of immune response|
|regulation of cellular localization|
|intracellular protein transport|
|regulation of protein localization|
|regulation of immune response|
|positive regulation of immune system process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of immune system process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.498|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17154
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STX7 Expression in NALM6 Cells: 5.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>