======= STX8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STX8
  * **<color #00a2e8>Official Name</color>**: syntaxin 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9482|9482]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UNK0|Q9UNK0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STX8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STX8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604203|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNARE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chloride channel inhibitor activity|
|early endosome to late endosome transport|
|vesicle-mediated transport between endosomal compartments|
|SNAP receptor activity|
|SNARE complex|
|endosome to lysosome transport|
|syntaxin binding|
|phagocytic vesicle|
|vesicle docking|
|SNARE binding|
|vesicle fusion|
|endomembrane system|
|organelle membrane fusion|
|regulation of protein localization to plasma membrane|
|organelle fusion|
|lysosomal transport|
|regulation of protein localization to cell periphery|
|recycling endosome|
|late endosome membrane|
|late endosome|
|membrane fusion|
|vacuolar transport|
|vesicle|
|cytosolic transport|
|cellular response to interferon-gamma|
|organelle localization by membrane tethering|
|trans-Golgi network|
|membrane docking|
|response to interferon-gamma|
|regulation of protein localization to membrane|
|early endosome|
|endosome|
|ubiquitin protein ligase binding|
|lysosomal membrane|
|vesicle organization|
|regulation of cellular protein localization|
|organelle localization|
|perinuclear region of cytoplasm|
|innate immune response|
|membrane organization|
|regulation of cellular localization|
|defense response to other organism|
|intracellular protein transport|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|regulation of protein localization|
|response to cytokine|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.14|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.8|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.72|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.75|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.78|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.84|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.87|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.87|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.93|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6895
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STX8 Expression in NALM6 Cells: 4.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>