======= SULF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SULF1
  * **<color #00a2e8>Official Name</color>**: sulfatase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23213|23213]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWU6|Q8IWU6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SULF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SULF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610012|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3740|
|Sulfatase|
|Phosphodiest|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|esophagus smooth muscle contraction|
|N-acetylglucosamine-6-sulfatase activity|
|negative regulation of prostatic bud formation|
|gastro-intestinal system smooth muscle contraction|
|regulation of prostatic bud formation|
|glial cell-derived neurotrophic factor receptor signaling pathway|
|glomerular basement membrane development|
|glomerular filtration|
|renal filtration|
|arylsulfatase activity|
|negative regulation of fibroblast growth factor receptor signaling pathway|
|negative regulation of morphogenesis of an epithelium|
|glycosaminoglycan binding|
|negative regulation of embryonic development|
|innervation|
|positive regulation of vascular endothelial growth factor production|
|regulation of fibroblast growth factor receptor signaling pathway|
|regulation of vascular endothelial growth factor production|
|positive regulation of BMP signaling pathway|
|negative regulation of animal organ morphogenesis|
|heparan sulfate proteoglycan metabolic process|
|regulation of animal organ formation|
|Golgi stack|
|negative regulation of endothelial cell proliferation|
|chondrocyte development|
|glomerulus development|
|smooth muscle contraction|
|negative regulation of reproductive process|
|regulation of morphogenesis of a branching structure|
|vascular endothelial growth factor receptor signaling pathway|
|nerve development|
|chondrocyte differentiation|
|regulation of BMP signaling pathway|
|proteoglycan metabolic process|
|negative regulation of angiogenesis|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of blood vessel morphogenesis|
|renal system process|
|negative regulation of vasculature development|
|negative regulation of epithelial cell proliferation|
|nephron development|
|embryonic skeletal system development|
|regulation of embryonic development|
|regulation of endothelial cell proliferation|
|negative regulation of cellular response to growth factor stimulus|
|regulation of reproductive process|
|cartilage development|
|positive regulation of Wnt signaling pathway|
|regulation of morphogenesis of an epithelium|
|bone development|
|connective tissue development|
|membrane raft|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|muscle contraction|
|regulation of animal organ morphogenesis|
|negative regulation of cell migration|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|renal system development|
|regulation of angiogenesis|
|muscle system process|
|negative regulation of cellular component movement|
|urogenital system development|
|regulation of vasculature development|
|negative regulation of locomotion|
|regulation of epithelial cell proliferation|
|extracellular matrix organization|
|regulation of Wnt signaling pathway|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|glycoprotein metabolic process|
|positive regulation of cytokine production|
|skeletal system development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell surface|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|negative regulation of cell population proliferation|
|regulation of cytokine production|
|enzyme linked receptor protein signaling pathway|
|calcium ion binding|
|regulation of cell migration|
|regulation of cell motility|
|apoptotic process|
|negative regulation of developmental process|
|embryo development|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cell development|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3242
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SULF1 Expression in NALM6 Cells: 0.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>