======= SUPV3L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUPV3L1
  * **<color #00a2e8>Official Name</color>**: Suv3 like RNA helicase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6832|6832]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IYB8|Q8IYB8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUPV3L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUPV3L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605122|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. {ECO:0000269|PubMed:12466530, ECO:0000269|PubMed:15096047, ECO:0000269|PubMed:17352692, ECO:0000269|PubMed:17961633, ECO:0000269|PubMed:18678873, ECO:0000269|PubMed:19509288, ECO:0000269|PubMed:19864255}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|SUV3 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ncRNA surveillance|
|cytoplasmic RNA surveillance|
|mitochondrial RNA surveillance|
|mitochondrial mRNA surveillance|
|positive regulation of mitochondrial RNA catabolic process|
|mitochondrial degradosome|
|mitochondrial RNA catabolic process|
|mitochondrial mRNA catabolic process|
|chromatin maintenance|
|regulation of mitochondrial RNA catabolic process|
|mitochondrial RNA 3-end processing|
|RNA surveillance|
|mitochondrial RNA processing|
|3-5 RNA helicase activity|
|mitochondrion morphogenesis|
|helicase activity|
|mitochondrial RNA metabolic process|
|mitochondrial nucleoid|
|cellular component maintenance|
|DNA helicase activity|
|RNA helicase activity|
|double-stranded RNA binding|
|DNA duplex unwinding|
|DNA geometric change|
|RNA 3-end processing|
|mitochondrial gene expression|
|positive regulation of cell growth|
|mRNA catabolic process|
|DNA recombination|
|RNA catabolic process|
|positive regulation of growth|
|DNA conformation change|
|positive regulation of cellular catabolic process|
|mitochondrial matrix|
|nucleobase-containing compound catabolic process|
|regulation of cell growth|
|positive regulation of catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|mitochondrion organization|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|cell part morphogenesis|
|regulation of growth|
|mRNA metabolic process|
|chromatin organization|
|DNA metabolic process|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|RNA processing|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|regulation of catabolic process|
|negative regulation of cell death|
|macromolecule catabolic process|
|chromosome organization|
|mitochondrion|
|RNA binding|
|DNA binding|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|RNA metabolic process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-2.25|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.22|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-2.17|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.79|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.72|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.76|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.78|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.8|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.81|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.87|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.88|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.88|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.89|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.95|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.02|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.08|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.13|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.14|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.14|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.63|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.63|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.69|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2.84|
|[[:results:exp539|42°C R08 exp539]]|2.98|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|3.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl21|MRPL21]]|0.708|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.7|
|[[:human genes:m:mrp63|MRP63]]|0.699|
|[[:human genes:m:mrps14|MRPS14]]|0.667|
|[[:human genes:s:slc25a26|SLC25A26]]|0.664|
|[[:human genes:c:cox16|COX16]]|0.657|
|[[:human genes:y:yars2|YARS2]]|0.654|
|[[:human genes:m:mrps18a|MRPS18A]]|0.649|
|[[:human genes:m:mrps34|MRPS34]]|0.649|
|[[:human genes:m:mrps6|MRPS6]]|0.647|
|[[:human genes:m:mrpl23|MRPL23]]|0.645|
|[[:human genes:m:mrps16|MRPS16]]|0.635|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.631|
|[[:human genes:s:sars2|SARS2]]|0.628|
|[[:human genes:t:tufm|TUFM]]|0.628|
|[[:human genes:d:dap3|DAP3]]|0.627|
|[[:human genes:m:mrps21|MRPS21]]|0.626|
|[[:human genes:d:dars2|DARS2]]|0.621|
|[[:human genes:s:sco2|SCO2]]|0.614|
|[[:human genes:w:wbscr16|WBSCR16]]|0.612|
|[[:human genes:m:mrpl53|MRPL53]]|0.611|
|[[:human genes:t:tars2|TARS2]]|0.608|
|[[:human genes:s:selrc1|SELRC1]]|0.607|
|[[:human genes:g:gfm1|GFM1]]|0.607|
|[[:human genes:b:bcs1l|BCS1L]]|0.607|
|[[:human genes:m:mrps5|MRPS5]]|0.605|
|[[:human genes:v:vars2|VARS2]]|0.599|
|[[:human genes:t:triap1|TRIAP1]]|0.597|
|[[:human genes:r:rpusd4|RPUSD4]]|0.596|
|[[:human genes:m:mrps9|MRPS9]]|0.596|
|[[:human genes:p:pnpt1|PNPT1]]|0.59|
|[[:human genes:n:ndufa3|NDUFA3]]|0.589|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.588|
|[[:human genes:a:atp5a1|ATP5A1]]|0.586|
|[[:human genes:m:mrpl47|MRPL47]]|0.577|
|[[:human genes:e:elac2|ELAC2]]|0.577|
|[[:human genes:m:mrps26|MRPS26]]|0.567|
|[[:human genes:q:qrsl1|QRSL1]]|0.565|
|[[:human genes:p:pdss1|PDSS1]]|0.563|
|[[:human genes:r:rbfa|RBFA]]|0.563|
|[[:human genes:t:trub2|TRUB2]]|0.563|
|[[:human genes:c:cox7b|COX7B]]|0.562|
|[[:human genes:m:mrpl34|MRPL34]]|0.555|
|[[:human genes:h:hccs|HCCS]]|0.554|
|[[:human genes:n:nars2|NARS2]]|0.554|
|[[:human genes:m:mrpl36|MRPL36]]|0.553|
|[[:human genes:m:mrpl15|MRPL15]]|0.553|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.552|
|[[:human genes:f:fars2|FARS2]]|0.552|
|[[:human genes:p:pmm2|PMM2]]|0.551|
|[[:human genes:p:pars2|PARS2]]|0.551|
|[[:human genes:d:dohh|DOHH]]|0.55|
|[[:human genes:m:mrps23|MRPS23]]|0.55|
|[[:human genes:c:c12orf65|C12orf65]]|0.549|
|[[:human genes:t:tmem242|TMEM242]]|0.549|
|[[:human genes:m:mtpap|MTPAP]]|0.548|
|[[:human genes:c:chchd4|CHCHD4]]|0.548|
|[[:human genes:e:ears2|EARS2]]|0.547|
|[[:human genes:m:mrpl20|MRPL20]]|0.547|
|[[:human genes:m:mrps10|MRPS10]]|0.546|
|[[:human genes:t:tefm|TEFM]]|0.545|
|[[:human genes:m:mrps2|MRPS2]]|0.543|
|[[:human genes:a:alg1|ALG1]]|0.543|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.54|
|[[:human genes:t:thg1l|THG1L]]|0.539|
|[[:human genes:r:rars2|RARS2]]|0.538|
|[[:human genes:a:atp5d|ATP5D]]|0.538|
|[[:human genes:d:dpagt1|DPAGT1]]|0.538|
|[[:human genes:m:mrps11|MRPS11]]|0.538|
|[[:human genes:f:fastkd5|FASTKD5]]|0.537|
|[[:human genes:m:mrps12|MRPS12]]|0.537|
|[[:human genes:m:mrpl42|MRPL42]]|0.537|
|[[:human genes:g:gfm2|GFM2]]|0.535|
|[[:human genes:m:mrpl44|MRPL44]]|0.534|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.533|
|[[:human genes:m:mrps25|MRPS25]]|0.533|
|[[:human genes:m:mrpl55|MRPL55]]|0.532|
|[[:human genes:m:mrps33|MRPS33]]|0.531|
|[[:human genes:h:hars2|HARS2]]|0.529|
|[[:human genes:m:mrps24|MRPS24]]|0.528|
|[[:human genes:c:c10orf2|C10orf2]]|0.526|
|[[:human genes:m:mrpl33|MRPL33]]|0.526|
|[[:human genes:n:ndufb11|NDUFB11]]|0.525|
|[[:human genes:c:crls1|CRLS1]]|0.524|
|[[:human genes:a:atp5b|ATP5B]]|0.523|
|[[:human genes:c:c17orf89|C17orf89]]|0.522|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.521|
|[[:human genes:r:romo1|ROMO1]]|0.52|
|[[:human genes:p:ppcs|PPCS]]|0.519|
|[[:human genes:t:taz|TAZ]]|0.519|
|[[:human genes:a:atxn10|ATXN10]]|0.517|
|[[:human genes:c:cox6c|COX6C]]|0.517|
|[[:human genes:a:aifm1|AIFM1]]|0.516|
|[[:human genes:c:coq3|COQ3]]|0.515|
|[[:human genes:m:mars2|MARS2]]|0.513|
|[[:human genes:m:mrpl45|MRPL45]]|0.513|
|[[:human genes:t:tamm41|TAMM41]]|0.511|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.51|
|[[:human genes:u:uap1|UAP1]]|0.51|
|[[:human genes:m:mrpl12|MRPL12]]|0.51|
|[[:human genes:n:ndufb5|NDUFB5]]|0.506|
|[[:human genes:g:gatc|GATC]]|0.506|
|[[:human genes:u:uqcr10|UQCR10]]|0.505|
|[[:human genes:m:mtg2|MTG2]]|0.504|
|[[:human genes:a:atp5o|ATP5O]]|0.502|
|[[:human genes:r:rpe|RPE]]|0.501|
|[[:human genes:u:uhrf1|UHRF1]]|0.497|
|[[:human genes:t:tfam|TFAM]]|0.495|
|[[:human genes:r:rpia|RPIA]]|0.494|
|[[:human genes:m:mrpl3|MRPL3]]|0.493|
|[[:human genes:t:trnt1|TRNT1]]|0.492|
|[[:human genes:h:higd2a|HIGD2A]]|0.491|
|[[:human genes:n:ndufc2|NDUFC2]]|0.49|
|[[:human genes:c:coa5|COA5]]|0.489|
|[[:human genes:l:lars2|LARS2]]|0.489|
|[[:human genes:a:atp5c1|ATP5C1]]|0.488|
|[[:human genes:c:cox17|COX17]]|0.487|
|[[:human genes:d:dhrsx|DHRSX]]|0.486|
|[[:human genes:f:fh|FH]]|0.486|
|[[:human genes:c:coq2|COQ2]]|0.484|
|[[:human genes:t:ttc4|TTC4]]|0.484|
|[[:human genes:u:uqcrq|UQCRQ]]|0.481|
|[[:human genes:m:mrpl18|MRPL18]]|0.48|
|[[:human genes:m:mrpl41|MRPL41]]|0.478|
|[[:human genes:t:timm8b|TIMM8B]]|0.476|
|[[:human genes:a:atp5j|ATP5J]]|0.475|
|[[:human genes:c:cox15|COX15]]|0.474|
|[[:human genes:t:tpk1|TPK1]]|0.473|
|[[:human genes:o:opa1|OPA1]]|0.472|
|[[:human genes:d:dhx30|DHX30]]|0.472|
|[[:human genes:n:ndufa1|NDUFA1]]|0.47|
|[[:human genes:m:mrps17|MRPS17]]|0.469|
|[[:human genes:a:atp5h|ATP5H]]|0.468|
|[[:human genes:v:vezt|VEZT]]|0.467|
|[[:human genes:m:mbtps2|MBTPS2]]|0.467|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.467|
|[[:human genes:m:mrpl11|MRPL11]]|0.466|
|[[:human genes:m:mrpl27|MRPL27]]|0.466|
|[[:human genes:a:alg13|ALG13]]|0.466|
|[[:human genes:s:ssb|SSB]]|0.465|
|[[:human genes:t:tomm40|TOMM40]]|0.464|
|[[:human genes:f:ftsj2|FTSJ2]]|0.462|
|[[:human genes:t:tomm22|TOMM22]]|0.461|
|[[:human genes:n:ndufb6|NDUFB6]]|0.461|
|[[:human genes:m:mrpl22|MRPL22]]|0.46|
|[[:human genes:c:cycs|CYCS]]|0.456|
|[[:human genes:p:ppa2|PPA2]]|0.456|
|[[:human genes:c:coa3|COA3]]|0.455|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.455|
|[[:human genes:t:tmem41b|TMEM41B]]|0.454|
|[[:human genes:g:gfer|GFER]]|0.453|
|[[:human genes:d:dnlz|DNLZ]]|0.452|
|[[:human genes:m:mrpl52|MRPL52]]|0.451|
|[[:human genes:t:tmem126b|TMEM126B]]|0.451|
|[[:human genes:t:tomm20|TOMM20]]|0.45|
|[[:human genes:g:gmppb|GMPPB]]|0.45|
|[[:human genes:s:srp14|SRP14]]|0.45|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.45|
|[[:human genes:g:gfpt1|GFPT1]]|0.449|
|[[:human genes:r:rptor|RPTOR]]|0.447|
|[[:human genes:n:ndufb3|NDUFB3]]|0.447|
|[[:human genes:b:bap1|BAP1]]|0.446|
|[[:human genes:a:adsl|ADSL]]|0.446|
|[[:human genes:m:mtg1|MTG1]]|0.445|
|[[:human genes:l:lsm10|LSM10]]|0.442|
|[[:human genes:c:coa6|COA6]]|0.442|
|[[:human genes:m:mrpl13|MRPL13]]|0.441|
|[[:human genes:s:slc25a19|SLC25A19]]|0.441|
|[[:human genes:t:trmt10a|TRMT10A]]|0.439|
|[[:human genes:l:lrpprc|LRPPRC]]|0.439|
|[[:human genes:t:trmt5|TRMT5]]|0.438|
|[[:human genes:n:ndufb1|NDUFB1]]|0.438|
|[[:human genes:r:rtcb|RTCB]]|0.437|
|[[:human genes:f:fastkd1|FASTKD1]]|0.437|
|[[:human genes:z:zrsr2|ZRSR2]]|0.436|
|[[:human genes:m:mrps22|MRPS22]]|0.436|
|[[:human genes:c:cbfb|CBFB]]|0.435|
|[[:human genes:m:mrpl46|MRPL46]]|0.433|
|[[:human genes:a:alg6|ALG6]]|0.432|
|[[:human genes:n:ndufa2|NDUFA2]]|0.432|
|[[:human genes:t:timm13|TIMM13]]|0.431|
|[[:human genes:n:ndufs7|NDUFS7]]|0.43|
|[[:human genes:p:polg|POLG]]|0.43|
|[[:human genes:n:nfu1|NFU1]]|0.43|
|[[:human genes:n:ndufv1|NDUFV1]]|0.43|
|[[:human genes:d:dhps|DHPS]]|0.429|
|[[:human genes:e:eif3f|EIF3F]]|0.428|
|[[:human genes:t:txnl4b|TXNL4B]]|0.428|
|[[:human genes:c:coq5|COQ5]]|0.427|
|[[:human genes:p:pgm3|PGM3]]|0.427|
|[[:human genes:t:trmt10c|TRMT10C]]|0.427|
|[[:human genes:c:cox6b1|COX6B1]]|0.427|
|[[:human genes:m:mrpl4|MRPL4]]|0.426|
|[[:human genes:a:aars2|AARS2]]|0.426|
|[[:human genes:a:alg5|ALG5]]|0.426|
|[[:human genes:m:mrpl32|MRPL32]]|0.426|
|[[:human genes:a:atic|ATIC]]|0.425|
|[[:human genes:g:glrx5|GLRX5]]|0.423|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.423|
|[[:human genes:c:cox10|COX10]]|0.421|
|[[:human genes:c:cox5a|COX5A]]|0.42|
|[[:human genes:t:timm17a|TIMM17A]]|0.419|
|[[:human genes:h:haus8|HAUS8]]|0.417|
|[[:human genes:c:cbx3|CBX3]]|0.417|
|[[:human genes:p:ptrhd1|PTRHD1]]|0.417|
|[[:human genes:u:uqcc2|UQCC2]]|0.417|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.417|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.417|
|[[:human genes:c:casp9|CASP9]]|0.416|
|[[:human genes:c:coq4|COQ4]]|0.416|
|[[:human genes:p:pggt1b|PGGT1B]]|0.415|
|[[:human genes:m:mrps7|MRPS7]]|0.414|
|[[:human genes:m:mipep|MIPEP]]|0.413|
|[[:human genes:r:rpusd3|RPUSD3]]|0.412|
|[[:human genes:m:mterfd2|MTERFD2]]|0.412|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.412|
|[[:human genes:i:iba57|IBA57]]|0.411|
|[[:human genes:m:mrpl39|MRPL39]]|0.41|
|[[:human genes:k:kdsr|KDSR]]|0.41|
|[[:human genes:s:sec62|SEC62]]|0.41|
|[[:human genes:p:polrmt|POLRMT]]|0.408|
|[[:human genes:p:polg2|POLG2]]|0.407|
|[[:human genes:u:ube2g2|UBE2G2]]|0.406|
|[[:human genes:m:mrpl28|MRPL28]]|0.406|
|[[:human genes:p:pet112|PET112]]|0.405|
|[[:human genes:t:trmt61a|TRMT61A]]|0.404|
|[[:human genes:e:eny2|ENY2]]|0.403|
|[[:human genes:m:mtfmt|MTFMT]]|0.402|
|[[:human genes:m:mrpl17|MRPL17]]|0.402|
|[[:human genes:n:ndufb9|NDUFB9]]|0.401|
|[[:human genes:r:rnmt|RNMT]]|0.401|
|[[:human genes:i:isca2|ISCA2]]|0.401|
|[[:human genes:g:gemin8|GEMIN8]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 533/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|21/28|
|bone|14/26|
|breast|25/33|
|central nervous system|40/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|12/21|
|liver|15/20|
|lung|54/75|
|lymphocyte|13/16|
|ovary|15/26|
|pancreas|17/24|
|peripheral nervous system|6/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|19/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|21/22|
|urinary tract|25/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 124
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUPV3L1 Expression in NALM6 Cells: 6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>