======= SUZ12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUZ12
  * **<color #00a2e8>Official Name</color>**: SUZ12 polycomb repressive complex 2 subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23512|23512]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15022|Q15022]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUZ12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUZ12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606245|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VEFS-Box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RSC-type complex|
|histone methyltransferase activity (H3-K27 specific)|
|sex chromatin|
|histone methyltransferase activity|
|histone H3-K27 methylation|
|ESC/E(Z) complex|
|negative regulation of G0 to G1 transition|
|histone ubiquitination|
|regulation of G0 to G1 transition|
|protein-DNA complex|
|promoter-specific chromatin binding|
|methylated histone binding|
|chromatin DNA binding|
|histone lysine methylation|
|negative regulation of gene expression, epigenetic|
|peptidyl-lysine methylation|
|histone methylation|
|protein alkylation|
|protein methylation|
|regulation of gene expression, epigenetic|
|macromolecule methylation|
|nuclear body|
|methylation|
|peptidyl-lysine modification|
|negative regulation of cell cycle process|
|histone modification|
|covalent chromatin modification|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|negative regulation of cell cycle|
|protein ubiquitination|
|chromatin organization|
|negative regulation of cell differentiation|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|negative regulation of gene expression|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.41|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.26|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.18|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.97|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.73|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.72|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.76|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.98|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.13|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.54|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.63|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.85|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eed|EED]]|0.688|
|[[:human genes:e:ezh2|EZH2]]|0.687|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1501
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUZ12 Expression in NALM6 Cells: 7.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>