======= TACC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TACC3
  * **<color #00a2e8>Official Name</color>**: transforming acidic coiled-coil containing protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10460|10460]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6A5|Q9Y6A5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TACC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TACC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605303|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TACC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|metaphase/anaphase transition of mitotic cell cycle|
|metaphase/anaphase transition of cell cycle|
|regulation of mitotic spindle organization|
|regulation of spindle organization|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|mitotic spindle organization|
|mitotic spindle|
|regulation of sister chromatid segregation|
|regulation of chromosome segregation|
|microtubule cytoskeleton organization involved in mitosis|
|cerebral cortex development|
|spindle pole|
|spindle organization|
|microtubule organizing center|
|regulation of mitotic nuclear division|
|pallium development|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|regulation of microtubule-based process|
|telencephalon development|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|regulation of chromosome organization|
|forebrain development|
|microtubule cytoskeleton organization|
|cell division|
|regulation of cytoskeleton organization|
|cell population proliferation|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|brain development|
|regulation of cell cycle process|
|head development|
|central nervous system development|
|cell cycle process|
|cytoskeleton organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-4.25|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-3.81|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-3.48|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-3.48|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-3.4|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-3.25|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.96|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.93|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.91|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-2.83|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.61|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.58|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.5|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.5|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.41|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-2.38|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.32|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.28|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.27|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.19|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.13|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.11|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.99|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.98|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dlgap5|DLGAP5]]|0.75|
|[[:human genes:g:gak|GAK]]|0.648|
|[[:human genes:g:gtse1|GTSE1]]|0.582|
|[[:human genes:a:aspm|ASPM]]|0.537|
|[[:human genes:k:kif15|KIF15]]|0.531|
|[[:human genes:g:gsg2|GSG2]]|0.531|
|[[:human genes:c:cdca2|CDCA2]]|0.52|
|[[:human genes:s:sephs1|SEPHS1]]|0.501|
|[[:human genes:e:esco2|ESCO2]]|0.487|
|[[:human genes:m:mapre1|MAPRE1]]|0.476|
|[[:human genes:c:calm2|CALM2]]|0.457|
|[[:human genes:k:klf16|KLF16]]|0.448|
|[[:human genes:u:ube4b|UBE4B]]|0.417|
|[[:human genes:c:cltc|CLTC]]|0.414|
|[[:human genes:b:brap|BRAP]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 77/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|2/26|
|breast|3/33|
|central nervous system|6/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|2/21|
|liver|1/20|
|lung|6/75|
|lymphocyte|2/16|
|ovary|6/26|
|pancreas|3/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|2/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|9/22|
|urinary tract|4/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2778
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TACC3 Expression in NALM6 Cells: 8.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>