======= TAF15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAF15
  * **<color #00a2e8>Official Name</color>**: TATA-box binding protein associated factor 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8148|8148]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92804|Q92804]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAF15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAF15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601574|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). {ECO:0000269|PubMed:19124016}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-RanBP|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription initiation from RNA polymerase II promoter|
|regulation of signal transduction by p53 class mediator|
|DNA-templated transcription, initiation|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleolus|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.11|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.9|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.9|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.73|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.73|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.79|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.81|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.94|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.98|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.01|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.11|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.15|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.27|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.27|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.31|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.49|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.49|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.76|
|[[:results:exp135|MS023 7μM R03 exp135]]|3.85|
|[[:results:exp134|MS023 2μM R03 exp134]]|5.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.521|
|[[:human genes:c:c14orf93|C14orf93]]|0.46|
|[[:human genes:p:psmb4|PSMB4]]|0.441|
|[[:human genes:n:npipb5|NPIPB5]]|0.437|
|[[:human genes:p:psap|PSAP]]|0.424|
|[[:human genes:r:rrn3|RRN3]]|0.42|
|[[:human genes:p:paf1|PAF1]]|0.419|
|[[:human genes:c:cep192|CEP192]]|0.417|
|[[:human genes:s:supt6h|SUPT6H]]|0.417|
|[[:human genes:c:cdc73|CDC73]]|0.414|
|[[:human genes:s:snrnp70|SNRNP70]]|0.414|
|[[:human genes:r:rps9|RPS9]]|0.408|
|[[:human genes:r:rps5|RPS5]]|0.404|
|[[:human genes:s:supt5h|SUPT5H]]|0.403|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.4|
|[[:human genes:r:rpl35|RPL35]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2028
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAF15 Expression in NALM6 Cells: 8.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>