======= TAF6L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAF6L
  * **<color #00a2e8>Official Name</color>**: TATA-box binding protein associated factor 6 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10629|10629]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6J9|Q9Y6J9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAF6L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAF6L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602946|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TAF|
|DUF1546|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SLIK (SAGA-like) complex|
|STAGA complex|
|RNA polymerase II preinitiation complex assembly|
|SAGA complex|
|transcription preinitiation complex assembly|
|histone deacetylase complex|
|transcription factor TFIID complex|
|histone H3 acetylation|
|histone acetyltransferase activity|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|chromatin remodeling|
|transcription initiation from RNA polymerase II promoter|
|protein acylation|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|protein-DNA complex subunit organization|
|transcription coactivator activity|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromatin organization|
|cellular protein-containing complex assembly|
|peptidyl-amino acid modification|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.17|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-2.01|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.81|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.7|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.71|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.75|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.76|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.81|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.99|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.12|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.5|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:supt7l|SUPT7L]]|0.673|
|[[:human genes:t:tada2b|TADA2B]]|0.667|
|[[:human genes:t:tada1|TADA1]]|0.631|
|[[:human genes:t:taf5l|TAF5L]]|0.626|
|[[:human genes:m:med13|MED13]]|0.621|
|[[:human genes:c:ccdc101|CCDC101]]|0.604|
|[[:human genes:t:tada3|TADA3]]|0.592|
|[[:human genes:s:supt20h|SUPT20H]]|0.568|
|[[:human genes:m:med23|MED23]]|0.552|
|[[:human genes:m:mllt1|MLLT1]]|0.531|
|[[:human genes:m:med13l|MED13L]]|0.516|
|[[:human genes:t:tle4|TLE4]]|0.51|
|[[:human genes:a:atxn7|ATXN7]]|0.501|
|[[:human genes:h:hdac8|HDAC8]]|0.5|
|[[:human genes:b:brpf1|BRPF1]]|0.48|
|[[:human genes:u:usp22|USP22]]|0.468|
|[[:human genes:p:prr12|PRR12]]|0.465|
|[[:human genes:k:kat2a|KAT2A]]|0.452|
|[[:human genes:e:ehmt2|EHMT2]]|0.44|
|[[:human genes:m:med16|MED16]]|0.43|
|[[:human genes:f:fli1|FLI1]]|0.43|
|[[:human genes:u:ube3a|UBE3A]]|0.424|
|[[:human genes:t:tti2|TTI2]]|0.42|
|[[:human genes:a:atf7ip|ATF7IP]]|0.417|
|[[:human genes:m:med7|MED7]]|0.409|
|[[:human genes:w:wdr24|WDR24]]|0.404|
|[[:human genes:m:med25|MED25]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 14/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 511
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAF6L Expression in NALM6 Cells: 4.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>