======= TAOK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAOK3
  * **<color #00a2e8>Official Name</color>**: TAO kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51347|51347]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2K8|Q9H2K8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAOK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAOK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616711|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). {ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic G2 DNA damage checkpoint|
|MAP kinase kinase kinase activity|
|mitotic G2/M transition checkpoint|
|protein kinase inhibitor activity|
|G2 DNA damage checkpoint|
|negative regulation of JNK cascade|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of stress-activated protein kinase signaling cascade|
|activation of MAPKK activity|
|transferase activity|
|positive regulation of JUN kinase activity|
|regulation of JUN kinase activity|
|negative regulation of G2/M transition of mitotic cell cycle|
|mitotic DNA damage checkpoint|
|negative regulation of cell cycle G2/M phase transition|
|mitotic DNA integrity checkpoint|
|DNA damage checkpoint|
|positive regulation of JNK cascade|
|stress-activated protein kinase signaling cascade|
|DNA integrity checkpoint|
|mitotic cell cycle checkpoint|
|negative regulation of MAPK cascade|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of JNK cascade|
|cell cycle checkpoint|
|protein autophosphorylation|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of protein kinase activity|
|negative regulation of cell cycle phase transition|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of kinase activity|
|positive regulation of MAP kinase activity|
|negative regulation of transferase activity|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|protein serine/threonine kinase activity|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|negative regulation of intracellular signal transduction|
|DNA repair|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|mitotic cell cycle|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|protein phosphorylation|
|regulation of transferase activity|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.27|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.22|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.98|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.89|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.74|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15415
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAOK3 Expression in NALM6 Cells: 6.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>