======= TAPT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAPT1
  * **<color #00a2e8>Official Name</color>**: transmembrane anterior posterior transformation 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=202018|202018]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6NXT6|Q6NXT6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAPT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAPT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612758|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a highly conserved protein that localizes to the centrosome and/or ciliary basal body. Mutations in this gene disrupt Golgi morphology and trafficking and normal primary cilium formation and these mutations are congenitally manifested by severe undermineralization of the intra-uterine skeleton. A mutation in the mouse ortholog of this gene results in homeotic, posterior-to-anterior transformations of the axial skeleton which are similar to the phenotype of mouse homeobox C8 gene mutants. In mouse, this gene is thought to function downstream of homeobox C8 to transduce extracellular patterning information during axial skeleton development. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in primary cilia formation (PubMed:26365339). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity). {ECO:0000250|UniProtKB:A2BIE7, ECO:0000250|UniProtKB:Q4VBD2, ECO:0000269|PubMed:26365339}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF747|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|growth hormone-releasing hormone receptor activity|
|positive regulation of bone development|
|maintenance of protein localization in endoplasmic reticulum|
|regulation of bone development|
|positive regulation of cilium assembly|
|positive regulation of cartilage development|
|maintenance of protein localization in organelle|
|regulation of cartilage development|
|maintenance of protein location in cell|
|positive regulation of organelle assembly|
|neural crest cell development|
|regulation of cilium assembly|
|stem cell development|
|mesenchymal cell development|
|post-embryonic development|
|neural crest cell differentiation|
|maintenance of location in cell|
|positive regulation of plasma membrane bounded cell projection assembly|
|maintenance of protein location|
|integral component of endoplasmic reticulum membrane|
|embryonic skeletal system development|
|protein localization to endoplasmic reticulum|
|ciliary basal body|
|mesenchymal cell differentiation|
|stem cell differentiation|
|maintenance of location|
|cartilage development|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of organelle assembly|
|mesenchyme development|
|connective tissue development|
|ossification|
|in utero embryonic development|
|positive regulation of cell projection organization|
|centrosome|
|skeletal system development|
|positive regulation of cellular component biogenesis|
|positive regulation of organelle organization|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|protein localization to organelle|
|regulation of cellular component biogenesis|
|embryo development|
|endoplasmic reticulum|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|cellular protein localization|
|cellular macromolecule localization|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10185
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAPT1 Expression in NALM6 Cells: 7.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>