======= TARS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TARS2
  * **<color #00a2e8>Official Name</color>**: threonyl-tRNA synthetase 2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80222|80222]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BW92|Q9BW92]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TARS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TARS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612805|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain. {ECO:0000269|PubMed:26811336}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGS|
|tRNA-synt 2b|
|tRNA SAD|
|HGTP anticodon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial threonyl-tRNA aminoacylation|
|threonyl-tRNA aminoacylation|
|threonine-tRNA ligase activity|
|tRNA aminoacylation for mitochondrial protein translation|
|aminoacyl-tRNA metabolism involved in translational fidelity|
|aminoacyl-tRNA editing activity|
|regulation of translational fidelity|
|mitochondrial RNA metabolic process|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|mitochondrial translation|
|mitochondrial gene expression|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|translation|
|peptide biosynthetic process|
|cellular component|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.7|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.7|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.7|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.73|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.73|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.75|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.75|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.79|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.8|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.81|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.84|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.85|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.91|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.99|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.01|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.02|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.03|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.04|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.06|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.07|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.12|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.19|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.22|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.22|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.76|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|3.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.782|
|[[:human genes:y:yars2|YARS2]]|0.761|
|[[:human genes:n:nars2|NARS2]]|0.749|
|[[:human genes:p:pars2|PARS2]]|0.738|
|[[:human genes:s:selrc1|SELRC1]]|0.733|
|[[:human genes:g:gfm1|GFM1]]|0.732|
|[[:human genes:s:sco2|SCO2]]|0.726|
|[[:human genes:m:mrps34|MRPS34]]|0.721|
|[[:human genes:m:mrps6|MRPS6]]|0.72|
|[[:human genes:d:dap3|DAP3]]|0.718|
|[[:human genes:m:mrps16|MRPS16]]|0.707|
|[[:human genes:v:vars2|VARS2]]|0.705|
|[[:human genes:m:mrpl23|MRPL23]]|0.699|
|[[:human genes:m:mtg2|MTG2]]|0.698|
|[[:human genes:r:rpusd4|RPUSD4]]|0.697|
|[[:human genes:m:mrpl21|MRPL21]]|0.697|
|[[:human genes:e:ears2|EARS2]]|0.695|
|[[:human genes:m:mrps21|MRPS21]]|0.692|
|[[:human genes:m:mrpl53|MRPL53]]|0.674|
|[[:human genes:r:rbfa|RBFA]]|0.672|
|[[:human genes:m:mrps14|MRPS14]]|0.671|
|[[:human genes:m:mrps5|MRPS5]]|0.666|
|[[:human genes:c:cox16|COX16]]|0.665|
|[[:human genes:n:ndufb11|NDUFB11]]|0.665|
|[[:human genes:q:qrsl1|QRSL1]]|0.664|
|[[:human genes:l:lars2|LARS2]]|0.663|
|[[:human genes:d:dars2|DARS2]]|0.652|
|[[:human genes:f:fastkd5|FASTKD5]]|0.649|
|[[:human genes:m:mrps18a|MRPS18A]]|0.647|
|[[:human genes:m:mrps2|MRPS2]]|0.642|
|[[:human genes:b:bcs1l|BCS1L]]|0.642|
|[[:human genes:a:aars2|AARS2]]|0.641|
|[[:human genes:m:mrp63|MRP63]]|0.64|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.639|
|[[:human genes:m:mrpl12|MRPL12]]|0.638|
|[[:human genes:g:gatc|GATC]]|0.636|
|[[:human genes:m:mars2|MARS2]]|0.635|
|[[:human genes:m:mrps25|MRPS25]]|0.627|
|[[:human genes:m:mrps26|MRPS26]]|0.627|
|[[:human genes:s:sars2|SARS2]]|0.625|
|[[:human genes:r:rars2|RARS2]]|0.625|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.624|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.619|
|[[:human genes:m:mrpl47|MRPL47]]|0.618|
|[[:human genes:c:c10orf2|C10orf2]]|0.618|
|[[:human genes:c:coa3|COA3]]|0.616|
|[[:human genes:h:hars2|HARS2]]|0.615|
|[[:human genes:w:wbscr16|WBSCR16]]|0.613|
|[[:human genes:p:polg2|POLG2]]|0.611|
|[[:human genes:c:coa6|COA6]]|0.608|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.608|
|[[:human genes:m:mrpl3|MRPL3]]|0.608|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.607|
|[[:human genes:p:pet112|PET112]]|0.606|
|[[:human genes:n:ndufa3|NDUFA3]]|0.605|
|[[:human genes:p:pnpt1|PNPT1]]|0.603|
|[[:human genes:m:mrps24|MRPS24]]|0.602|
|[[:human genes:m:mrps10|MRPS10]]|0.596|
|[[:human genes:c:c12orf65|C12orf65]]|0.596|
|[[:human genes:g:gfm2|GFM2]]|0.595|
|[[:human genes:t:tefm|TEFM]]|0.591|
|[[:human genes:f:ftsj2|FTSJ2]]|0.59|
|[[:human genes:t:tufm|TUFM]]|0.588|
|[[:human genes:c:cox11|COX11]]|0.583|
|[[:human genes:m:mrpl45|MRPL45]]|0.581|
|[[:human genes:p:polg|POLG]]|0.58|
|[[:human genes:m:mrps9|MRPS9]]|0.572|
|[[:human genes:m:mrpl20|MRPL20]]|0.571|
|[[:human genes:m:mtg1|MTG1]]|0.57|
|[[:human genes:m:mrpl15|MRPL15]]|0.568|
|[[:human genes:m:mrpl34|MRPL34]]|0.566|
|[[:human genes:p:polrmt|POLRMT]]|0.566|
|[[:human genes:p:pet117|PET117]]|0.563|
|[[:human genes:f:fars2|FARS2]]|0.559|
|[[:human genes:c:cox15|COX15]]|0.556|
|[[:human genes:t:tomm20|TOMM20]]|0.554|
|[[:human genes:c:cox17|COX17]]|0.552|
|[[:human genes:w:wars2|WARS2]]|0.551|
|[[:human genes:m:mtpap|MTPAP]]|0.551|
|[[:human genes:m:mrps33|MRPS33]]|0.548|
|[[:human genes:m:mrps12|MRPS12]]|0.547|
|[[:human genes:m:mrps11|MRPS11]]|0.546|
|[[:human genes:p:pgm3|PGM3]]|0.544|
|[[:human genes:m:mrps35|MRPS35]]|0.542|
|[[:human genes:m:mettl17|METTL17]]|0.542|
|[[:human genes:n:ndufb5|NDUFB5]]|0.541|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.54|
|[[:human genes:m:mrps23|MRPS23]]|0.538|
|[[:human genes:m:mrpl11|MRPL11]]|0.536|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.535|
|[[:human genes:m:mrpl36|MRPL36]]|0.532|
|[[:human genes:a:aifm1|AIFM1]]|0.532|
|[[:human genes:t:tmem242|TMEM242]]|0.529|
|[[:human genes:m:mrpl43|MRPL43]]|0.528|
|[[:human genes:m:mrpl55|MRPL55]]|0.527|
|[[:human genes:n:ndufa2|NDUFA2]]|0.527|
|[[:human genes:t:tfam|TFAM]]|0.526|
|[[:human genes:m:mrps27|MRPS27]]|0.525|
|[[:human genes:c:cox7b|COX7B]]|0.524|
|[[:human genes:c:coq2|COQ2]]|0.523|
|[[:human genes:c:c17orf89|C17orf89]]|0.522|
|[[:human genes:m:mrpl44|MRPL44]]|0.521|
|[[:human genes:s:slc25a26|SLC25A26]]|0.52|
|[[:human genes:n:ndufa1|NDUFA1]]|0.519|
|[[:human genes:e:elac2|ELAC2]]|0.518|
|[[:human genes:n:ndufb6|NDUFB6]]|0.518|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.517|
|[[:human genes:c:cars2|CARS2]]|0.516|
|[[:human genes:c:cox6c|COX6C]]|0.514|
|[[:human genes:d:dnlz|DNLZ]]|0.514|
|[[:human genes:t:trub2|TRUB2]]|0.514|
|[[:human genes:m:mrpl4|MRPL4]]|0.511|
|[[:human genes:a:atp5a1|ATP5A1]]|0.509|
|[[:human genes:a:atp5c1|ATP5C1]]|0.506|
|[[:human genes:m:malsu1|MALSU1]]|0.505|
|[[:human genes:m:mipep|MIPEP]]|0.503|
|[[:human genes:m:mrps7|MRPS7]]|0.503|
|[[:human genes:m:mrpl42|MRPL42]]|0.501|
|[[:human genes:a:atp5d|ATP5D]]|0.5|
|[[:human genes:e:ecsit|ECSIT]]|0.498|
|[[:human genes:d:dhrsx|DHRSX]]|0.496|
|[[:human genes:m:mrpl39|MRPL39]]|0.495|
|[[:human genes:m:mterfd2|MTERFD2]]|0.493|
|[[:human genes:m:mrpl2|MRPL2]]|0.493|
|[[:human genes:r:rpusd3|RPUSD3]]|0.492|
|[[:human genes:f:fh|FH]]|0.492|
|[[:human genes:i:iba57|IBA57]]|0.492|
|[[:human genes:m:mrpl52|MRPL52]]|0.492|
|[[:human genes:r:rpia|RPIA]]|0.489|
|[[:human genes:n:ndufc2|NDUFC2]]|0.489|
|[[:human genes:c:cox5a|COX5A]]|0.488|
|[[:human genes:l:lsm10|LSM10]]|0.487|
|[[:human genes:c:chchd4|CHCHD4]]|0.487|
|[[:human genes:l:lrpprc|LRPPRC]]|0.486|
|[[:human genes:n:ndufs2|NDUFS2]]|0.483|
|[[:human genes:c:cox20|COX20]]|0.483|
|[[:human genes:p:pdss1|PDSS1]]|0.482|
|[[:human genes:u:uqcrq|UQCRQ]]|0.48|
|[[:human genes:a:atp5sl|ATP5SL]]|0.479|
|[[:human genes:c:coq3|COQ3]]|0.477|
|[[:human genes:c:chchd1|CHCHD1]]|0.476|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.474|
|[[:human genes:t:tfb1m|TFB1M]]|0.47|
|[[:human genes:m:mrps22|MRPS22]]|0.47|
|[[:human genes:m:mrpl18|MRPL18]]|0.469|
|[[:human genes:m:mrpl33|MRPL33]]|0.468|
|[[:human genes:g:grsf1|GRSF1]]|0.464|
|[[:human genes:m:mrpl37|MRPL37]]|0.463|
|[[:human genes:d:dhx30|DHX30]]|0.461|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.459|
|[[:human genes:p:ppa2|PPA2]]|0.458|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.458|
|[[:human genes:n:ndufs7|NDUFS7]]|0.458|
|[[:human genes:m:mrpl41|MRPL41]]|0.456|
|[[:human genes:m:mrpl32|MRPL32]]|0.455|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.454|
|[[:human genes:t:tmem261|TMEM261]]|0.454|
|[[:human genes:n:ndufb9|NDUFB9]]|0.453|
|[[:human genes:m:mtif3|MTIF3]]|0.452|
|[[:human genes:t:tpk1|TPK1]]|0.452|
|[[:human genes:s:ssbp1|SSBP1]]|0.452|
|[[:human genes:t:trmt61a|TRMT61A]]|0.45|
|[[:human genes:p:ptcd1|PTCD1]]|0.449|
|[[:human genes:t:tmem126b|TMEM126B]]|0.449|
|[[:human genes:g:g6pd|G6PD]]|0.449|
|[[:human genes:m:mterfd1|MTERFD1]]|0.448|
|[[:human genes:t:triap1|TRIAP1]]|0.448|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.447|
|[[:human genes:n:ndufs8|NDUFS8]]|0.446|
|[[:human genes:m:mrpl22|MRPL22]]|0.446|
|[[:human genes:m:mrpl17|MRPL17]]|0.446|
|[[:human genes:p:pmvk|PMVK]]|0.445|
|[[:human genes:c:c1qbp|C1QBP]]|0.445|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.445|
|[[:human genes:m:mrpl46|MRPL46]]|0.445|
|[[:human genes:a:acad9|ACAD9]]|0.444|
|[[:human genes:c:coa5|COA5]]|0.444|
|[[:human genes:n:ndufv1|NDUFV1]]|0.443|
|[[:human genes:m:mrpl49|MRPL49]]|0.443|
|[[:human genes:o:opa1|OPA1]]|0.44|
|[[:human genes:n:ndufb1|NDUFB1]]|0.44|
|[[:human genes:m:mrpl35|MRPL35]]|0.44|
|[[:human genes:m:mtif2|MTIF2]]|0.439|
|[[:human genes:a:atp5b|ATP5B]]|0.439|
|[[:human genes:n:ndufa10|NDUFA10]]|0.438|
|[[:human genes:m:mrpl13|MRPL13]]|0.437|
|[[:human genes:s:slc25a3|SLC25A3]]|0.435|
|[[:human genes:a:alas1|ALAS1]]|0.434|
|[[:human genes:t:tomm40|TOMM40]]|0.434|
|[[:human genes:f:fastkd1|FASTKD1]]|0.432|
|[[:human genes:u:uqcc2|UQCC2]]|0.43|
|[[:human genes:p:pet100|PET100]]|0.429|
|[[:human genes:s:slc25a19|SLC25A19]]|0.429|
|[[:human genes:s:ssb|SSB]]|0.429|
|[[:human genes:n:ndufa11|NDUFA11]]|0.428|
|[[:human genes:u:uqcr10|UQCR10]]|0.428|
|[[:human genes:c:coq7|COQ7]]|0.427|
|[[:human genes:p:ppcs|PPCS]]|0.426|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.426|
|[[:human genes:t:timm8b|TIMM8B]]|0.425|
|[[:human genes:p:ptcd3|PTCD3]]|0.423|
|[[:human genes:n:ndufc1|NDUFC1]]|0.423|
|[[:human genes:f:fastkd2|FASTKD2]]|0.422|
|[[:human genes:a:atp5h|ATP5H]]|0.422|
|[[:human genes:m:mrps28|MRPS28]]|0.422|
|[[:human genes:m:mcat|MCAT]]|0.42|
|[[:human genes:c:cox4i1|COX4I1]]|0.42|
|[[:human genes:m:mto1|MTO1]]|0.42|
|[[:human genes:n:nsun4|NSUN4]]|0.419|
|[[:human genes:a:alg6|ALG6]]|0.419|
|[[:human genes:p:pitrm1|PITRM1]]|0.418|
|[[:human genes:d:ddx28|DDX28]]|0.417|
|[[:human genes:p:pmm2|PMM2]]|0.413|
|[[:human genes:t:tfb2m|TFB2M]]|0.412|
|[[:human genes:t:tamm41|TAMM41]]|0.411|
|[[:human genes:n:ndufs5|NDUFS5]]|0.41|
|[[:human genes:n:ndufb3|NDUFB3]]|0.41|
|[[:human genes:m:mrps18b|MRPS18B]]|0.41|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.41|
|[[:human genes:t:tomm6|TOMM6]]|0.41|
|[[:human genes:n:nubpl|NUBPL]]|0.409|
|[[:human genes:g:gars|GARS]]|0.408|
|[[:human genes:e:eral1|ERAL1]]|0.407|
|[[:human genes:m:mrpl38|MRPL38]]|0.407|
|[[:human genes:t:ten1|TEN1]]|0.407|
|[[:human genes:h:higd2a|HIGD2A]]|0.406|
|[[:human genes:a:alg8|ALG8]]|0.406|
|[[:human genes:p:ptdss1|PTDSS1]]|0.404|
|[[:human genes:m:mrpl27|MRPL27]]|0.404|
|[[:human genes:c:coq6|COQ6]]|0.403|
|[[:human genes:a:aurkaip1|AURKAIP1]]|0.4|
|[[:human genes:h:hccs|HCCS]]|0.4|
|[[:human genes:m:mettl1|METTL1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 378/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|17/28|
|blood|11/28|
|bone|10/26|
|breast|22/33|
|central nervous system|20/56|
|cervix|2/4|
|colorectal|11/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|7/21|
|liver|9/20|
|lung|46/75|
|lymphocyte|4/16|
|ovary|4/26|
|pancreas|11/24|
|peripheral nervous system|6/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|12/24|
|soft tissue|5/9|
|thyroid|0/2|
|upper aerodigestive|14/22|
|urinary tract|20/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 245
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TARS2 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>