======= TBC1D20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBC1D20
  * **<color #00a2e8>Official Name</color>**: TBC1 domain family member 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=128637|128637]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96BZ9|Q96BZ9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBC1D20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBC1D20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611663|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that belongs to a family of GTPase activator proteins of Rab-like small GTPases. The encoded protein and its cognate GTPase, Rab1, bind the nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) to mediate viral replication. Depletion of this protein inhibits replication of the virus and HCV infection. Mutations in this gene are associated with Warburg micro syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TBC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of ER to Golgi vesicle-mediated transport|
|positive regulation by virus of viral protein levels in host cell|
|lens fiber cell morphogenesis|
|positive regulation by host of viral genome replication|
|regulation by virus of viral protein levels in host cell|
|seminiferous tubule development|
|COPII-coated vesicle cargo loading|
|lens fiber cell development|
|modulation by host of viral genome replication|
|regulation of ER to Golgi vesicle-mediated transport|
|positive regulation by host of viral process|
|acrosome assembly|
|lipid droplet organization|
|lens morphogenesis in camera-type eye|
|vesicle cargo loading|
|lens fiber cell differentiation|
|modulation by host of viral process|
|secretory granule organization|
|positive regulation of viral genome replication|
|virion assembly|
|positive regulation of viral life cycle|
|COPII vesicle coating|
|integral component of Golgi membrane|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|lens development in camera-type eye|
|Golgi vesicle budding|
|regulation of cilium assembly|
|localization within membrane|
|vesicle targeting|
|regulation of viral genome replication|
|vesicle budding from membrane|
|cellular component assembly involved in morphogenesis|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|camera-type eye morphogenesis|
|Golgi organization|
|male gonad development|
|development of primary male sexual characteristics|
|regulation of viral life cycle|
|eye morphogenesis|
|Rab GTPase binding|
|spermatid development|
|modification of morphology or physiology of other organism|
|spermatid differentiation|
|male sex differentiation|
|establishment of vesicle localization|
|vesicle localization|
|epithelial cell development|
|regulation of plasma membrane bounded cell projection assembly|
|viral life cycle|
|regulation of cell projection assembly|
|regulation of viral process|
|positive regulation of intracellular transport|
|gonad development|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|development of primary sexual characteristics|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of organelle assembly|
|nuclear membrane|
|sensory organ morphogenesis|
|germ cell development|
|sex differentiation|
|GTPase activator activity|
|vesicle organization|
|camera-type eye development|
|regulation of intracellular transport|
|cellular process involved in reproduction in multicellular organism|
|eye development|
|visual system development|
|establishment of organelle localization|
|sensory system development|
|Golgi vesicle transport|
|positive regulation of GTPase activity|
|endomembrane system organization|
|reproductive structure development|
|reproductive system development|
|regulation of GTPase activity|
|positive regulation of multi-organism process|
|spermatogenesis|
|sensory organ development|
|regulation of vesicle-mediated transport|
|cell morphogenesis involved in differentiation|
|male gamete generation|
|organelle localization|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|gamete generation|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|regulation of cell projection organization|
|cell morphogenesis|
|organelle assembly|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|membrane organization|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|multi-organism reproductive process|
|endoplasmic reticulum|
|chemical homeostasis|
|epithelium development|
|regulation of hydrolase activity|
|regulation of organelle organization|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|intracellular transport|
|protein-containing complex assembly|
|homeostatic process|
|cell development|
|tissue development|
|positive regulation of molecular function|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.9|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.25|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-2.22|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.09|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.02|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.94|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.93|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.93|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.87|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.76|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.76|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.72|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8447
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBC1D20 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>