======= TBC1D3C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBC1D3C
  * **<color #00a2e8>Official Name</color>**: TBC1 domain family member 3C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=414060|414060]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6IPX1|Q6IPX1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBC1D3C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBC1D3C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610806|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TBC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activation of GTPase activity|
|Rab GTPase binding|
|GTPase activator activity|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|positive regulation of hydrolase activity|
|intracellular protein transport|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.85|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.84|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.73|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.74|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.78|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.78|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.79|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.07|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.15|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.25|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.63|
|[[:human genes:p:psma6|PSMA6]]|0.596|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.587|
|[[:human genes:p:polr2j3|POLR2J3]]|0.579|
|[[:human genes:t:tfip11|TFIP11]]|0.578|
|[[:human genes:r:rps2|RPS2]]|0.577|
|[[:human genes:d:dtl|DTL]]|0.576|
|[[:human genes:v:vasn|VASN]]|0.574|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.567|
|[[:human genes:p:psmd3|PSMD3]]|0.556|
|[[:human genes:c:c14orf93|C14orf93]]|0.553|
|[[:human genes:s:supt6h|SUPT6H]]|0.552|
|[[:human genes:t:tceb3c|TCEB3C]]|0.55|
|[[:human genes:p:psmc1|PSMC1]]|0.548|
|[[:human genes:r:rbbp5|RBBP5]]|0.547|
|[[:human genes:o:ogfr|OGFR]]|0.541|
|[[:human genes:t:timeless|TIMELESS]]|0.539|
|[[:human genes:s:sec13|SEC13]]|0.539|
|[[:human genes:c:cbwd3|CBWD3]]|0.537|
|[[:human genes:r:rfxank|RFXANK]]|0.536|
|[[:human genes:s:ssh2|SSH2]]|0.533|
|[[:human genes:r:rrn3|RRN3]]|0.533|
|[[:human genes:r:rpl35|RPL35]]|0.532|
|[[:human genes:a:ankle2|ANKLE2]]|0.532|
|[[:human genes:m:med17|MED17]]|0.53|
|[[:human genes:c:chd4|CHD4]]|0.528|
|[[:human genes:d:ddtl|DDTL]]|0.528|
|[[:human genes:z:zfand5|ZFAND5]]|0.526|
|[[:human genes:z:znf106|ZNF106]]|0.525|
|[[:human genes:c:cbwd5|CBWD5]]|0.525|
|[[:human genes:m:mdm2|MDM2]]|0.523|
|[[:human genes:t:ticrr|TICRR]]|0.522|
|[[:human genes:z:znf655|ZNF655]]|0.517|
|[[:human genes:c:cgb2|CGB2]]|0.515|
|[[:human genes:n:nol12|NOL12]]|0.515|
|[[:human genes:k:kctd17|KCTD17]]|0.514|
|[[:human genes:n:nup43|NUP43]]|0.51|
|[[:human genes:c:cope|COPE]]|0.509|
|[[:human genes:s:supt5h|SUPT5H]]|0.506|
|[[:human genes:n:npipb5|NPIPB5]]|0.504|
|[[:human genes:p:psmb4|PSMB4]]|0.504|
|[[:human genes:c:cdc73|CDC73]]|0.501|
|[[:human genes:m:mcoln1|MCOLN1]]|0.501|
|[[:human genes:r:rps12|RPS12]]|0.499|
|[[:human genes:t:tspy1|TSPY1]]|0.498|
|[[:human genes:n:nupl1|NUPL1]]|0.497|
|[[:human genes:a:ankle1|ANKLE1]]|0.497|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.495|
|[[:human genes:s:syt9|SYT9]]|0.494|
|[[:human genes:c:ckap5|CKAP5]]|0.494|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.494|
|[[:human genes:t:twistnb|TWISTNB]]|0.492|
|[[:human genes:m:myb|MYB]]|0.492|
|[[:human genes:p:pola2|POLA2]]|0.492|
|[[:human genes:p:pan2|PAN2]]|0.492|
|[[:human genes:m:med14|MED14]]|0.491|
|[[:human genes:i:igfn1|IGFN1]]|0.491|
|[[:human genes:n:nbpf10|NBPF10]]|0.489|
|[[:human genes:p:pola1|POLA1]]|0.488|
|[[:human genes:p:pcf11|PCF11]]|0.488|
|[[:human genes:r:rad51|RAD51]]|0.487|
|[[:human genes:o:orc1|ORC1]]|0.487|
|[[:human genes:c:cbwd6|CBWD6]]|0.487|
|[[:human genes:r:rpl6|RPL6]]|0.487|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.486|
|[[:human genes:u:upf1|UPF1]]|0.486|
|[[:human genes:c:cactin|CACTIN]]|0.486|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.485|
|[[:human genes:f:fam160a1|FAM160A1]]|0.484|
|[[:human genes:r:rad21|RAD21]]|0.484|
|[[:human genes:o:orc6|ORC6]]|0.484|
|[[:human genes:p:pwp2|PWP2]]|0.483|
|[[:human genes:p:psmb1|PSMB1]]|0.482|
|[[:human genes:c:ccdc94|CCDC94]]|0.482|
|[[:human genes:t:tyms|TYMS]]|0.482|
|[[:human genes:r:rpl9|RPL9]]|0.481|
|[[:human genes:t:traip|TRAIP]]|0.481|
|[[:human genes:c:cdc6|CDC6]]|0.481|
|[[:human genes:a:aqr|AQR]]|0.48|
|[[:human genes:p:polr2d|POLR2D]]|0.48|
|[[:human genes:p:pbxip1|PBXIP1]]|0.479|
|[[:human genes:r:rrp7a|RRP7A]]|0.479|
|[[:human genes:m:mt1e|MT1E]]|0.479|
|[[:human genes:r:rps28|RPS28]]|0.478|
|[[:human genes:p:psmd1|PSMD1]]|0.477|
|[[:human genes:m:myo1h|MYO1H]]|0.477|
|[[:human genes:s:sf3a1|SF3A1]]|0.475|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.473|
|[[:human genes:p:prpf8|PRPF8]]|0.472|
|[[:human genes:p:ppfia4|PPFIA4]]|0.472|
|[[:human genes:n:nup107|NUP107]]|0.472|
|[[:human genes:s:stil|STIL]]|0.472|
|[[:human genes:r:riok2|RIOK2]]|0.471|
|[[:human genes:r:rnf4|RNF4]]|0.471|
|[[:human genes:g:golga6a|GOLGA6A]]|0.47|
|[[:human genes:i:ints6|INTS6]]|0.47|
|[[:human genes:t:trim52|TRIM52]]|0.47|
|[[:human genes:w:wdr87|WDR87]]|0.47|
|[[:human genes:h:hap1|HAP1]]|0.47|
|[[:human genes:d:dnm2|DNM2]]|0.469|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.469|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.468|
|[[:human genes:c:chmp2a|CHMP2A]]|0.468|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.468|
|[[:human genes:s:sel1l|SEL1L]]|0.468|
|[[:human genes:p:psmc6|PSMC6]]|0.467|
|[[:human genes:a:akirin2|AKIRIN2]]|0.467|
|[[:human genes:n:nfatc4|NFATC4]]|0.467|
|[[:human genes:n:narfl|NARFL]]|0.466|
|[[:human genes:l:lrr1|LRR1]]|0.466|
|[[:human genes:p:psap|PSAP]]|0.465|
|[[:human genes:c:col2a1|COL2A1]]|0.465|
|[[:human genes:r:rpl34|RPL34]]|0.464|
|[[:human genes:e:exosc8|EXOSC8]]|0.464|
|[[:human genes:s:s1pr4|S1PR4]]|0.463|
|[[:human genes:r:rps14|RPS14]]|0.463|
|[[:human genes:e:exosc9|EXOSC9]]|0.463|
|[[:human genes:r:rbm39|RBM39]]|0.462|
|[[:human genes:c:cdc45|CDC45]]|0.462|
|[[:human genes:p:psmd7|PSMD7]]|0.462|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.462|
|[[:human genes:s:slc4a1|SLC4A1]]|0.461|
|[[:human genes:p:polr2a|POLR2A]]|0.459|
|[[:human genes:s:sfpq|SFPQ]]|0.459|
|[[:human genes:h:hivep3|HIVEP3]]|0.459|
|[[:human genes:s:slc6a17|SLC6A17]]|0.458|
|[[:human genes:n:nop16|NOP16]]|0.458|
|[[:human genes:d:ddx56|DDX56]]|0.458|
|[[:human genes:t:tpx2|TPX2]]|0.458|
|[[:human genes:p:psmc2|PSMC2]]|0.458|
|[[:human genes:n:nup153|NUP153]]|0.457|
|[[:human genes:p:psmb2|PSMB2]]|0.457|
|[[:human genes:a:atp13a1|ATP13A1]]|0.456|
|[[:human genes:r:rps5|RPS5]]|0.456|
|[[:human genes:p:psmb3|PSMB3]]|0.455|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.454|
|[[:human genes:e:exosc5|EXOSC5]]|0.453|
|[[:human genes:a:acsf2|ACSF2]]|0.453|
|[[:human genes:k:kpnb1|KPNB1]]|0.453|
|[[:human genes:c:ctr9|CTR9]]|0.452|
|[[:human genes:c:cdca3|CDCA3]]|0.452|
|[[:human genes:e:exosc3|EXOSC3]]|0.451|
|[[:human genes:m:myh2|MYH2]]|0.451|
|[[:human genes:n:nup205|NUP205]]|0.451|
|[[:human genes:f:fcn2|FCN2]]|0.451|
|[[:human genes:c:copb1|COPB1]]|0.45|
|[[:human genes:m:madcam1|MADCAM1]]|0.45|
|[[:human genes:k:kif3c|KIF3C]]|0.449|
|[[:human genes:n:nup85|NUP85]]|0.449|
|[[:human genes:d:disp2|DISP2]]|0.447|
|[[:human genes:e:elmod3|ELMOD3]]|0.447|
|[[:human genes:w:wdr75|WDR75]]|0.446|
|[[:human genes:m:med29|MED29]]|0.446|
|[[:human genes:p:pole|POLE]]|0.446|
|[[:human genes:f:fbxw9|FBXW9]]|0.446|
|[[:human genes:l:lad1|LAD1]]|0.445|
|[[:human genes:a:aaas|AAAS]]|0.445|
|[[:human genes:n:npipb8|NPIPB8]]|0.445|
|[[:human genes:s:snrpa1|SNRPA1]]|0.444|
|[[:human genes:n:nup160|NUP160]]|0.444|
|[[:human genes:p:prpf19|PRPF19]]|0.442|
|[[:human genes:p:polr1a|POLR1A]]|0.442|
|[[:human genes:t:tspy8|TSPY8]]|0.441|
|[[:human genes:k:krt78|KRT78]]|0.441|
|[[:human genes:s:slc5a5|SLC5A5]]|0.441|
|[[:human genes:s:smg1|SMG1]]|0.44|
|[[:human genes:t:tgm5|TGM5]]|0.44|
|[[:human genes:u:utp20|UTP20]]|0.439|
|[[:human genes:m:msh5|MSH5]]|0.439|
|[[:human genes:s:smg7|SMG7]]|0.438|
|[[:human genes:p:pan3|PAN3]]|0.438|
|[[:human genes:m:myo18a|MYO18A]]|0.438|
|[[:human genes:g:golga8o|GOLGA8O]]|0.437|
|[[:human genes:s:scaf1|SCAF1]]|0.436|
|[[:human genes:s:sema6b|SEMA6B]]|0.436|
|[[:human genes:c:ccna2|CCNA2]]|0.436|
|[[:human genes:e:exosc6|EXOSC6]]|0.436|
|[[:human genes:d:dock6|DOCK6]]|0.436|
|[[:human genes:s:slc38a7|SLC38A7]]|0.436|
|[[:human genes:f:fam86b2|FAM86B2]]|0.435|
|[[:human genes:c:chaf1a|CHAF1A]]|0.435|
|[[:human genes:m:mat2a|MAT2A]]|0.435|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.434|
|[[:human genes:p:psmd6|PSMD6]]|0.434|
|[[:human genes:a:atxn1|ATXN1]]|0.434|
|[[:human genes:t:tspy2|TSPY2]]|0.434|
|[[:human genes:c:chmp4b|CHMP4B]]|0.433|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.433|
|[[:human genes:t:top1mt|TOP1MT]]|0.432|
|[[:human genes:m:mms22l|MMS22L]]|0.432|
|[[:human genes:a:add2|ADD2]]|0.432|
|[[:human genes:p:psma7|PSMA7]]|0.432|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.432|
|[[:human genes:c:cacna1a|CACNA1A]]|0.431|
|[[:human genes:g:golga6b|GOLGA6B]]|0.43|
|[[:human genes:c:cmya5|CMYA5]]|0.43|
|[[:human genes:p:psmc4|PSMC4]]|0.429|
|[[:human genes:r:rrp1|RRP1]]|0.429|
|[[:human genes:z:znf574|ZNF574]]|0.429|
|[[:human genes:r:rps9|RPS9]]|0.429|
|[[:human genes:r:rpl38|RPL38]]|0.428|
|[[:human genes:u:uqcrh|UQCRH]]|0.427|
|[[:human genes:n:nol10|NOL10]]|0.427|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.427|
|[[:human genes:r:rps7|RPS7]]|0.427|
|[[:human genes:r:rrp15|RRP15]]|0.427|
|[[:human genes:g:gid4|GID4]]|0.426|
|[[:human genes:t:tonsl|TONSL]]|0.426|
|[[:human genes:b:bysl|BYSL]]|0.425|
|[[:human genes:w:wdr43|WDR43]]|0.425|
|[[:human genes:x:xab2|XAB2]]|0.425|
|[[:human genes:p:psmd13|PSMD13]]|0.424|
|[[:human genes:a:aamp|AAMP]]|0.424|
|[[:human genes:m:mbd3l2|MBD3L2]]|0.424|
|[[:human genes:p:psmd11|PSMD11]]|0.424|
|[[:human genes:p:paf1|PAF1]]|0.424|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.423|
|[[:human genes:c:cnot1|CNOT1]]|0.422|
|[[:human genes:i:ik|IK]]|0.422|
|[[:human genes:r:rpl30|RPL30]]|0.421|
|[[:human genes:g:gosr2|GOSR2]]|0.421|
|[[:human genes:a:aatf|AATF]]|0.421|
|[[:human genes:c:copa|COPA]]|0.421|
|[[:human genes:r:rpl14|RPL14]]|0.421|
|[[:human genes:u:utp3|UTP3]]|0.42|
|[[:human genes:s:snrnp70|SNRNP70]]|0.42|
|[[:human genes:s:sf3a3|SF3A3]]|0.42|
|[[:human genes:a:akap1|AKAP1]]|0.42|
|[[:human genes:r:rps20|RPS20]]|0.419|
|[[:human genes:c:chchd3|CHCHD3]]|0.418|
|[[:human genes:c:cep192|CEP192]]|0.418|
|[[:human genes:n:nup62|NUP62]]|0.417|
|[[:human genes:m:mfsd12|MFSD12]]|0.417|
|[[:human genes:e:egr2|EGR2]]|0.416|
|[[:human genes:p:psmd2|PSMD2]]|0.416|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.416|
|[[:human genes:p:psmd14|PSMD14]]|0.415|
|[[:human genes:e:eif4a3|EIF4A3]]|0.415|
|[[:human genes:c:copz1|COPZ1]]|0.414|
|[[:human genes:s:strn|STRN]]|0.414|
|[[:human genes:r:rpl4|RPL4]]|0.414|
|[[:human genes:m:myt1l|MYT1L]]|0.413|
|[[:human genes:s:sult1a3|SULT1A3]]|0.413|
|[[:human genes:v:vps54|VPS54]]|0.413|
|[[:human genes:s:sart1|SART1]]|0.412|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.412|
|[[:human genes:t:topbp1|TOPBP1]]|0.412|
|[[:human genes:f:fam25b|FAM25B]]|0.412|
|[[:human genes:s:sult1a4|SULT1A4]]|0.412|
|[[:human genes:r:rps3a|RPS3A]]|0.411|
|[[:human genes:r:ran|RAN]]|0.411|
|[[:human genes:z:znf541|ZNF541]]|0.411|
|[[:human genes:p:polr2j|POLR2J]]|0.41|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.409|
|[[:human genes:s:sprr2b|SPRR2B]]|0.409|
|[[:human genes:n:ndc80|NDC80]]|0.409|
|[[:human genes:r:rpa2|RPA2]]|0.409|
|[[:human genes:n:npipb4|NPIPB4]]|0.409|
|[[:human genes:a:ahctf1|AHCTF1]]|0.408|
|[[:human genes:c:casc5|CASC5]]|0.407|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.407|
|[[:human genes:r:ranbp2|RANBP2]]|0.407|
|[[:human genes:c:c3orf17|C3orf17]]|0.406|
|[[:human genes:e:exd1|EXD1]]|0.405|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.405|
|[[:human genes:c:cdt1|CDT1]]|0.405|
|[[:human genes:v:vps28|VPS28]]|0.404|
|[[:human genes:r:rhbdd3|RHBDD3]]|0.404|
|[[:human genes:c:copg1|COPG1]]|0.404|
|[[:human genes:c:cplx3|CPLX3]]|0.404|
|[[:human genes:h:htatsf1|HTATSF1]]|0.404|
|[[:human genes:p:palb2|PALB2]]|0.404|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.403|
|[[:human genes:d:dync1i2|DYNC1I2]]|0.402|
|[[:human genes:a:arcn1|ARCN1]]|0.402|
|[[:human genes:w:wdr90|WDR90]]|0.401|
|[[:human genes:m:mfrp|MFRP]]|0.401|
|[[:human genes:p:pold1|POLD1]]|0.4|
|[[:human genes:c:ccdc116|CCDC116]]|0.4|
|[[:human genes:d:ddx23|DDX23]]|0.4|
|[[:human genes:n:nup133|NUP133]]|0.4|
|[[:human genes:z:znf219|ZNF219]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1165
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBC1D3C Expression in NALM6 Cells: 0.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>