======= TBC1D3E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBC1D3E
  * **<color #00a2e8>Official Name</color>**: TBC1 domain family member 3E
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=102723859|102723859]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A0A087X179|A0A087X179]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBC1D3E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBC1D3E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610808|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250|UniProtKB:Q8IZP1}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TBC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activation of GTPase activity|
|Rab GTPase binding|
|GTPase activator activity|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|positive regulation of hydrolase activity|
|intracellular protein transport|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.38|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.32|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-2.22|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.77|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.77|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.75|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.72|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.71|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.73|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|1.74|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.78|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.8|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.84|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.88|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.96|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.97|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.97|
|[[:results:exp132|Metformin 40μM R03 exp132]]|2.06|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|2.1|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|2.12|
|[[:results:exp124|GSK343 3μM R03 exp124]]|2.12|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|2.16|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|2.33|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.61|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|2.69|
|[[:results:exp187|proTAME 5μM R04 exp187]]|2.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.583|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.579|
|[[:human genes:r:rps2|RPS2]]|0.561|
|[[:human genes:t:tfip11|TFIP11]]|0.558|
|[[:human genes:p:psma6|PSMA6]]|0.558|
|[[:human genes:v:vasn|VASN]]|0.553|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.553|
|[[:human genes:t:tceb3c|TCEB3C]]|0.546|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.54|
|[[:human genes:d:dtl|DTL]]|0.535|
|[[:human genes:t:timeless|TIMELESS]]|0.525|
|[[:human genes:p:psmd3|PSMD3]]|0.524|
|[[:human genes:c:c14orf93|C14orf93]]|0.523|
|[[:human genes:r:rbbp5|RBBP5]]|0.516|
|[[:human genes:c:chd4|CHD4]]|0.515|
|[[:human genes:r:rps28|RPS28]]|0.511|
|[[:human genes:l:lrr1|LRR1]]|0.51|
|[[:human genes:f:fam160a1|FAM160A1]]|0.509|
|[[:human genes:d:ddtl|DDTL]]|0.506|
|[[:human genes:m:myb|MYB]]|0.505|
|[[:human genes:c:cdc73|CDC73]]|0.503|
|[[:human genes:a:aqr|AQR]]|0.502|
|[[:human genes:k:kctd17|KCTD17]]|0.502|
|[[:human genes:p:pwp2|PWP2]]|0.502|
|[[:human genes:c:ccdc94|CCDC94]]|0.502|
|[[:human genes:m:mt1e|MT1E]]|0.501|
|[[:human genes:r:rpl35|RPL35]]|0.5|
|[[:human genes:c:cbwd5|CBWD5]]|0.495|
|[[:human genes:c:cbwd3|CBWD3]]|0.494|
|[[:human genes:t:ticrr|TICRR]]|0.494|
|[[:human genes:p:psmb1|PSMB1]]|0.493|
|[[:human genes:p:psmc1|PSMC1]]|0.492|
|[[:human genes:w:wdr87|WDR87]]|0.49|
|[[:human genes:s:syt9|SYT9]]|0.489|
|[[:human genes:s:supt6h|SUPT6H]]|0.487|
|[[:human genes:r:rrn3|RRN3]]|0.487|
|[[:human genes:c:cactin|CACTIN]]|0.487|
|[[:human genes:s:supt5h|SUPT5H]]|0.486|
|[[:human genes:t:tpx2|TPX2]]|0.485|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.482|
|[[:human genes:e:exosc8|EXOSC8]]|0.482|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.482|
|[[:human genes:r:rbm39|RBM39]]|0.481|
|[[:human genes:a:ankle2|ANKLE2]]|0.481|
|[[:human genes:o:ogfr|OGFR]]|0.48|
|[[:human genes:c:cgb2|CGB2]]|0.48|
|[[:human genes:r:rps5|RPS5]]|0.479|
|[[:human genes:s:sf3a1|SF3A1]]|0.479|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.479|
|[[:human genes:m:mdm2|MDM2]]|0.479|
|[[:human genes:r:rpl6|RPL6]]|0.479|
|[[:human genes:t:tyms|TYMS]]|0.478|
|[[:human genes:t:traip|TRAIP]]|0.478|
|[[:human genes:z:znf655|ZNF655]]|0.478|
|[[:human genes:p:psmb4|PSMB4]]|0.477|
|[[:human genes:r:rpl34|RPL34]]|0.476|
|[[:human genes:r:rps12|RPS12]]|0.475|
|[[:human genes:e:exosc9|EXOSC9]]|0.473|
|[[:human genes:d:ddx56|DDX56]]|0.473|
|[[:human genes:m:mcoln1|MCOLN1]]|0.471|
|[[:human genes:f:fcn2|FCN2]]|0.47|
|[[:human genes:n:narfl|NARFL]]|0.47|
|[[:human genes:d:dnm2|DNM2]]|0.469|
|[[:human genes:r:rad51|RAD51]]|0.468|
|[[:human genes:n:nfatc4|NFATC4]]|0.468|
|[[:human genes:m:myo1h|MYO1H]]|0.467|
|[[:human genes:u:utp3|UTP3]]|0.467|
|[[:human genes:b:bysl|BYSL]]|0.466|
|[[:human genes:n:nop16|NOP16]]|0.465|
|[[:human genes:r:riok2|RIOK2]]|0.465|
|[[:human genes:p:prpf8|PRPF8]]|0.464|
|[[:human genes:p:psmb2|PSMB2]]|0.464|
|[[:human genes:n:nupl1|NUPL1]]|0.464|
|[[:human genes:p:pan3|PAN3]]|0.464|
|[[:human genes:s:sec13|SEC13]]|0.463|
|[[:human genes:o:orc1|ORC1]]|0.463|
|[[:human genes:m:med17|MED17]]|0.463|
|[[:human genes:k:kif3c|KIF3C]]|0.462|
|[[:human genes:r:rrp7a|RRP7A]]|0.462|
|[[:human genes:n:nol10|NOL10]]|0.462|
|[[:human genes:p:pola1|POLA1]]|0.462|
|[[:human genes:c:ckap5|CKAP5]]|0.462|
|[[:human genes:p:psap|PSAP]]|0.461|
|[[:human genes:z:znf574|ZNF574]]|0.459|
|[[:human genes:r:rps7|RPS7]]|0.459|
|[[:human genes:c:cdc6|CDC6]]|0.459|
|[[:human genes:e:exosc5|EXOSC5]]|0.459|
|[[:human genes:c:cbwd6|CBWD6]]|0.459|
|[[:human genes:n:nol12|NOL12]]|0.458|
|[[:human genes:c:cope|COPE]]|0.458|
|[[:human genes:c:copb1|COPB1]]|0.457|
|[[:human genes:u:upf1|UPF1]]|0.457|
|[[:human genes:c:col2a1|COL2A1]]|0.457|
|[[:human genes:r:rfxank|RFXANK]]|0.456|
|[[:human genes:a:akirin2|AKIRIN2]]|0.455|
|[[:human genes:z:zfand5|ZFAND5]]|0.455|
|[[:human genes:p:psma7|PSMA7]]|0.455|
|[[:human genes:s:ssh2|SSH2]]|0.454|
|[[:human genes:p:psmd1|PSMD1]]|0.454|
|[[:human genes:n:npipb5|NPIPB5]]|0.454|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.454|
|[[:human genes:p:psmd11|PSMD11]]|0.453|
|[[:human genes:e:exosc3|EXOSC3]]|0.453|
|[[:human genes:c:chaf1a|CHAF1A]]|0.452|
|[[:human genes:p:pola2|POLA2]]|0.451|
|[[:human genes:p:pbxip1|PBXIP1]]|0.451|
|[[:human genes:p:psmd7|PSMD7]]|0.451|
|[[:human genes:t:tspy1|TSPY1]]|0.451|
|[[:human genes:k:krt78|KRT78]]|0.45|
|[[:human genes:r:rps14|RPS14]]|0.45|
|[[:human genes:c:ccna2|CCNA2]]|0.45|
|[[:human genes:p:pcf11|PCF11]]|0.45|
|[[:human genes:m:madcam1|MADCAM1]]|0.45|
|[[:human genes:s:slc4a1|SLC4A1]]|0.45|
|[[:human genes:t:trim52|TRIM52]]|0.449|
|[[:human genes:c:cacna1a|CACNA1A]]|0.448|
|[[:human genes:z:znf106|ZNF106]]|0.447|
|[[:human genes:r:rpl30|RPL30]]|0.446|
|[[:human genes:n:npipb8|NPIPB8]]|0.445|
|[[:human genes:s:sult1a3|SULT1A3]]|0.445|
|[[:human genes:g:golga6b|GOLGA6B]]|0.445|
|[[:human genes:s:sult1a4|SULT1A4]]|0.444|
|[[:human genes:i:igfn1|IGFN1]]|0.443|
|[[:human genes:s:slc6a17|SLC6A17]]|0.442|
|[[:human genes:m:med29|MED29]]|0.442|
|[[:human genes:h:hap1|HAP1]]|0.442|
|[[:human genes:p:ppfia4|PPFIA4]]|0.442|
|[[:human genes:k:kpnb1|KPNB1]]|0.442|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.441|
|[[:human genes:m:myo18a|MYO18A]]|0.441|
|[[:human genes:r:rps11|RPS11]]|0.441|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.44|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.44|
|[[:human genes:r:rrp15|RRP15]]|0.439|
|[[:human genes:o:orc6|ORC6]]|0.439|
|[[:human genes:s:sfpq|SFPQ]]|0.439|
|[[:human genes:m:med14|MED14]]|0.438|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.438|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.438|
|[[:human genes:m:myt1l|MYT1L]]|0.438|
|[[:human genes:p:psmc6|PSMC6]]|0.437|
|[[:human genes:t:top1mt|TOP1MT]]|0.437|
|[[:human genes:p:pan2|PAN2]]|0.437|
|[[:human genes:p:paf1|PAF1]]|0.437|
|[[:human genes:a:aamp|AAMP]]|0.437|
|[[:human genes:r:rps20|RPS20]]|0.436|
|[[:human genes:n:napa|NAPA]]|0.436|
|[[:human genes:a:arcn1|ARCN1]]|0.436|
|[[:human genes:n:nbpf10|NBPF10]]|0.436|
|[[:human genes:p:psmd14|PSMD14]]|0.435|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.435|
|[[:human genes:a:acsf2|ACSF2]]|0.435|
|[[:human genes:c:copg1|COPG1]]|0.433|
|[[:human genes:r:rnf4|RNF4]]|0.432|
|[[:human genes:r:rpa2|RPA2]]|0.432|
|[[:human genes:c:ctr9|CTR9]]|0.431|
|[[:human genes:s:s1pr4|S1PR4]]|0.431|
|[[:human genes:h:hivep3|HIVEP3]]|0.431|
|[[:human genes:c:chmp2a|CHMP2A]]|0.43|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.43|
|[[:human genes:p:pole|POLE]]|0.429|
|[[:human genes:r:rpl9|RPL9]]|0.429|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.428|
|[[:human genes:s:sel1l|SEL1L]]|0.427|
|[[:human genes:t:terf2|TERF2]]|0.427|
|[[:human genes:a:add2|ADD2]]|0.426|
|[[:human genes:m:msh5|MSH5]]|0.425|
|[[:human genes:i:ints6|INTS6]]|0.425|
|[[:human genes:n:nup107|NUP107]]|0.424|
|[[:human genes:p:psmc2|PSMC2]]|0.424|
|[[:human genes:c:cmya5|CMYA5]]|0.424|
|[[:human genes:x:xylt2|XYLT2]]|0.424|
|[[:human genes:c:casc3|CASC3]]|0.424|
|[[:human genes:p:polr1a|POLR1A]]|0.424|
|[[:human genes:n:ndc80|NDC80]]|0.423|
|[[:human genes:c:cep192|CEP192]]|0.422|
|[[:human genes:n:nup62|NUP62]]|0.422|
|[[:human genes:f:fbxw9|FBXW9]]|0.422|
|[[:human genes:f:fam20a|FAM20A]]|0.422|
|[[:human genes:i:iscu|ISCU]]|0.422|
|[[:human genes:s:srrt|SRRT]]|0.421|
|[[:human genes:f:fam86b2|FAM86B2]]|0.421|
|[[:human genes:c:copz1|COPZ1]]|0.421|
|[[:human genes:w:wdr75|WDR75]]|0.419|
|[[:human genes:s:snrpa1|SNRPA1]]|0.419|
|[[:human genes:p:psmb3|PSMB3]]|0.419|
|[[:human genes:c:cdca3|CDCA3]]|0.418|
|[[:human genes:g:golga8o|GOLGA8O]]|0.418|
|[[:human genes:w:wdr90|WDR90]]|0.417|
|[[:human genes:t:tspy2|TSPY2]]|0.417|
|[[:human genes:p:polr2a|POLR2A]]|0.417|
|[[:human genes:l:lad1|LAD1]]|0.417|
|[[:human genes:t:tuba8|TUBA8]]|0.417|
|[[:human genes:a:ankle1|ANKLE1]]|0.417|
|[[:human genes:p:psmd2|PSMD2]]|0.417|
|[[:human genes:s:scaf1|SCAF1]]|0.417|
|[[:human genes:r:rps9|RPS9]]|0.416|
|[[:human genes:t:twistnb|TWISTNB]]|0.416|
|[[:human genes:c:copa|COPA]]|0.416|
|[[:human genes:c:cdc45|CDC45]]|0.416|
|[[:human genes:s:sart1|SART1]]|0.415|
|[[:human genes:z:znf219|ZNF219]]|0.415|
|[[:human genes:p:psmd8|PSMD8]]|0.414|
|[[:human genes:e:elmod3|ELMOD3]]|0.414|
|[[:human genes:a:atp13a1|ATP13A1]]|0.414|
|[[:human genes:r:rps19|RPS19]]|0.412|
|[[:human genes:f:fbxl19|FBXL19]]|0.412|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.412|
|[[:human genes:t:tspy8|TSPY8]]|0.412|
|[[:human genes:c:c3orf17|C3orf17]]|0.412|
|[[:human genes:a:aatf|AATF]]|0.412|
|[[:human genes:n:nup43|NUP43]]|0.412|
|[[:human genes:n:nup153|NUP153]]|0.412|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.411|
|[[:human genes:r:rad21|RAD21]]|0.411|
|[[:human genes:a:akt1s1|AKT1S1]]|0.41|
|[[:human genes:c:cnpy3|CNPY3]]|0.41|
|[[:human genes:g:gid4|GID4]]|0.41|
|[[:human genes:p:psmd13|PSMD13]]|0.409|
|[[:human genes:r:rpl14|RPL14]]|0.408|
|[[:human genes:s:smg1|SMG1]]|0.408|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.408|
|[[:human genes:n:nup54|NUP54]]|0.408|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.408|
|[[:human genes:r:rps10|RPS10]]|0.407|
|[[:human genes:g:gar1|GAR1]]|0.407|
|[[:human genes:p:ppm1d|PPM1D]]|0.407|
|[[:human genes:f:fam25b|FAM25B]]|0.406|
|[[:human genes:u:ube2q2l|UBE2Q2L]]|0.406|
|[[:human genes:p:prpf19|PRPF19]]|0.406|
|[[:human genes:p:palb2|PALB2]]|0.406|
|[[:human genes:i:ik|IK]]|0.405|
|[[:human genes:p:psmc5|PSMC5]]|0.405|
|[[:human genes:m:myh7b|MYH7B]]|0.405|
|[[:human genes:x:xab2|XAB2]]|0.404|
|[[:human genes:e:egr2|EGR2]]|0.404|
|[[:human genes:e:exd1|EXD1]]|0.404|
|[[:human genes:s:smg7|SMG7]]|0.404|
|[[:human genes:a:adra1d|ADRA1D]]|0.404|
|[[:human genes:m:myh2|MYH2]]|0.404|
|[[:human genes:n:nup85|NUP85]]|0.403|
|[[:human genes:v:vps28|VPS28]]|0.403|
|[[:human genes:m:mms22l|MMS22L]]|0.402|
|[[:human genes:a:art5|ART5]]|0.402|
|[[:human genes:c:ccdc116|CCDC116]]|0.401|
|[[:human genes:u:ubald1|UBALD1]]|0.401|
|[[:human genes:r:rps3a|RPS3A]]|0.401|
|[[:human genes:u:utp20|UTP20]]|0.4|
|[[:human genes:o:or10g3|OR10G3]]|0.4|
|[[:human genes:c:cplx3|CPLX3]]|0.4|
|[[:human genes:n:nup205|NUP205]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 546
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBC1D3E Expression in NALM6 Cells: -0.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>