======= TCOF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TCOF1
  * **<color #00a2e8>Official Name</color>**: treacle ribosome biogenesis factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6949|6949]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13428|Q13428]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TCOF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TCOF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606847|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:26399832}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Treacle|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleolar large rRNA transcription by RNA polymerase I|
|RNA polymerase I core binding|
|neural crest formation|
|rRNA transcription|
|transcription by RNA polymerase I|
|transporter activity|
|scaffold protein binding|
|epithelial to mesenchymal transition|
|neural crest cell development|
|mesenchymal cell development|
|stem cell development|
|neural crest cell differentiation|
|ncRNA transcription|
|fibrillar center|
|mesenchymal cell differentiation|
|stem cell differentiation|
|mesenchyme development|
|regulation of translation|
|regulation of cellular amide metabolic process|
|protein heterodimerization activity|
|skeletal system development|
|posttranscriptional regulation of gene expression|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|nucleolus|
|anatomical structure formation involved in morphogenesis|
|embryo development|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|cellular nitrogen compound biosynthetic process|
|cell development|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|tissue development|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-2.38|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.24|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.05|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.99|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.97|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.96|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.95|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.89|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.86|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.84|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.84|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.77|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.71|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.71|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.7|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 59/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|0/26|
|breast|4/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|4/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|6/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3294
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TCOF1 Expression in NALM6 Cells: 8.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>