======= TCTN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TCTN1
  * **<color #00a2e8>Official Name</color>**: tectonic family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79600|79600]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q2MV58|Q2MV58]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TCTN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TCTN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609863|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of secreted and transmembrane proteins. The orthologous gene in mouse functions downstream of smoothened and rab23 to modulate hedgehog signal transduction. This protein is a component of the tectonic-like complex, which forms a barrier between the ciliary axoneme and the basal body. A mutation in this gene was found in a family with Joubert syndrome-13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1619|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|central nervous system interneuron axonogenesis|
|somatic motor neuron differentiation|
|protein localization to ciliary transition zone|
|MKS complex|
|dorsal/ventral neural tube patterning|
|spinal cord motor neuron differentiation|
|neural tube patterning|
|central nervous system neuron axonogenesis|
|protein localization to cilium|
|ventral spinal cord development|
|cell differentiation in spinal cord|
|regulation of smoothened signaling pathway|
|central nervous system neuron development|
|dorsal/ventral pattern formation|
|ciliary basal body-plasma membrane docking|
|neural tube formation|
|spinal cord development|
|embryonic epithelial tube formation|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|neural tube development|
|organelle localization by membrane tethering|
|membrane docking|
|central nervous system neuron differentiation|
|telencephalon development|
|epithelial tube morphogenesis|
|regionalization|
|cilium assembly|
|cytoskeleton|
|cilium organization|
|axonogenesis|
|in utero embryonic development|
|forebrain development|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|organelle localization|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|neuron projection development|
|cell morphogenesis|
|protein localization to organelle|
|brain development|
|organelle assembly|
|head development|
|neuron development|
|cellular component morphogenesis|
|tube development|
|anatomical structure formation involved in morphogenesis|
|embryo development|
|central nervous system development|
|neuron differentiation|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|generation of neurons|
|cellular protein localization|
|cellular macromolecule localization|
|extracellular space|
|neurogenesis|
|cell development|
|tissue development|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11623
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TCTN1 Expression in NALM6 Cells: 4.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>