======= TDG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TDG
  * **<color #00a2e8>Official Name</color>**: thymine DNA glycosylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6996|6996]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13569|Q13569]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TDG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TDG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601423|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5- hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5- methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar- phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. {ECO:0000269|PubMed:21862836, ECO:0000269|PubMed:22327402, ECO:0000269|PubMed:22573813, ECO:0000269|PubMed:22962365, ECO:0000269|PubMed:8127859, ECO:0000269|PubMed:8407958, ECO:0000269|PubMed:8662714}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UDG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|G/U mismatch-specific uracil-DNA glycosylase activity|
|regulation of DNA N-glycosylase activity|
|pyrimidine-specific mismatch base pair DNA N-glycosylase activity|
|uracil DNA N-glycosylase activity|
|oxidative DNA demethylation|
|depyrimidination|
|sodium ion binding|
|mismatched DNA binding|
|negative regulation of chromatin binding|
|DNA N-glycosylase activity|
|base-excision repair, AP site formation|
|SUMO binding|
|pyrimidine deoxyribonucleotide catabolic process|
|chloride ion binding|
|pyrimidine nucleotide catabolic process|
|DNA demethylation|
|deoxyribonucleotide catabolic process|
|oxidative demethylation|
|pyrimidine deoxyribonucleotide metabolic process|
|deoxyribose phosphate catabolic process|
|regulation of chromatin binding|
|DNA dealkylation|
|2-deoxyribonucleotide metabolic process|
|deoxyribose phosphate metabolic process|
|mismatch repair|
|deoxyribonucleotide metabolic process|
|base-excision repair|
|pyrimidine-containing compound catabolic process|
|protein kinase C binding|
|protein self-association|
|damaged DNA binding|
|pyrimidine nucleotide metabolic process|
|demethylation|
|DNA methylation or demethylation|
|nucleotide catabolic process|
|nucleoside phosphate catabolic process|
|transcription coregulator activity|
|DNA modification|
|PML body|
|negative regulation of protein binding|
|double-stranded DNA binding|
|nucleobase-containing small molecule biosynthetic process|
|pyrimidine-containing compound metabolic process|
|organophosphate catabolic process|
|regulation of embryonic development|
|negative regulation of binding|
|carbohydrate derivative catabolic process|
|magnesium ion binding|
|regulation of protein binding|
|regulation of gene expression, epigenetic|
|protein domain specific binding|
|transcription factor binding|
|nucleobase-containing compound catabolic process|
|regulation of binding|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|DNA repair|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|chromatin organization|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|organophosphate metabolic process|
|oxidation-reduction process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|negative regulation of gene expression|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13212
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TDG Expression in NALM6 Cells: 7.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>