======= TDGF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TDGF1
  * **<color #00a2e8>Official Name</color>**: teratocarcinoma-derived growth factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6997|6997]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13385|P13385]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TDGF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TDGF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953). {ECO:0000269|PubMed:11909953, ECO:0000269|PubMed:27881714}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CFC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activin receptor binding|
|nodal binding|
|nodal signaling pathway|
|anterior/posterior axis specification, embryo|
|tripartite regional subdivision|
|cellular response to hepatocyte growth factor stimulus|
|response to hepatocyte growth factor|
|blastoderm segmentation|
|cell migration involved in sprouting angiogenesis|
|activin receptor signaling pathway|
|extrinsic component of plasma membrane|
|blood vessel endothelial cell migration|
|cellular response to interleukin-6|
|response to interleukin-6|
|embryonic axis specification|
|cellular response to epidermal growth factor stimulus|
|response to epidermal growth factor|
|anterior/posterior axis specification|
|epidermal growth factor receptor signaling pathway|
|sprouting angiogenesis|
|embryonic pattern specification|
|endothelial cell migration|
|somatic stem cell population maintenance|
|ERBB signaling pathway|
|epithelial cell migration|
|axis specification|
|epithelium migration|
|BMP signaling pathway|
|tissue migration|
|segmentation|
|positive regulation of endothelial cell migration|
|anchored component of membrane|
|cellular response to BMP stimulus|
|response to BMP|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|mammary gland development|
|stem cell population maintenance|
|maintenance of cell number|
|positive regulation of epithelial cell migration|
|activation of MAPK activity|
|regulation of endothelial cell migration|
|cellular response to interferon-gamma|
|growth factor activity|
|morphogenesis of a branching structure|
|ameboidal-type cell migration|
|peptidyl-serine phosphorylation|
|response to interferon-gamma|
|positive regulation of peptidyl-tyrosine phosphorylation|
|peptidyl-serine modification|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|anterior/posterior pattern specification|
|regulation of epithelial cell migration|
|membrane raft|
|cellular response to tumor necrosis factor|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of MAP kinase activity|
|response to tumor necrosis factor|
|angiogenesis|
|apical plasma membrane|
|activation of protein kinase activity|
|regionalization|
|signaling receptor binding|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|blood vessel morphogenesis|
|gland development|
|pattern specification process|
|blood vessel development|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|positive regulation of kinase activity|
|cell surface|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|innate immune response|
|regulation of protein kinase activity|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|defense response to other organism|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10942
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TDGF1 Expression in NALM6 Cells: 1.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>