======= TEFM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TEFM
  * **<color #00a2e8>Official Name</color>**: transcription elongation factor, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79736|79736]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96QE5|Q96QE5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TEFM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TEFM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616422|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery. {ECO:0000269|PubMed:21278163}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HHH 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription elongation from mitochondrial promoter|
|DNA polymerase processivity factor activity|
|crossover junction endodeoxyribonuclease activity|
|mitochondrial DNA replication|
|mitochondrial transcription|
|mitochondrial RNA metabolic process|
|mitochondrial nucleoid|
|DNA-templated transcription, elongation|
|oxidative phosphorylation|
|DNA-dependent DNA replication|
|mitochondrial gene expression|
|ribonucleoprotein complex|
|ATP metabolic process|
|DNA replication|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|RNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.75|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.81|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.84|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.86|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.9|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.01|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.02|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.03|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.04|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.13|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.14|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.2|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.2|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.26|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.27|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.38|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.43|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.59|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.66|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:y:yars2|YARS2]]|0.687|
|[[:human genes:m:mrps21|MRPS21]]|0.657|
|[[:human genes:n:nars2|NARS2]]|0.642|
|[[:human genes:m:mrps14|MRPS14]]|0.638|
|[[:human genes:d:dars2|DARS2]]|0.614|
|[[:human genes:e:ears2|EARS2]]|0.612|
|[[:human genes:c:c10orf2|C10orf2]]|0.611|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.606|
|[[:human genes:m:mrpl53|MRPL53]]|0.605|
|[[:human genes:m:mrpl21|MRPL21]]|0.605|
|[[:human genes:g:gatc|GATC]]|0.603|
|[[:human genes:r:rpusd4|RPUSD4]]|0.598|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.592|
|[[:human genes:g:gfm1|GFM1]]|0.592|
|[[:human genes:m:mrps16|MRPS16]]|0.592|
|[[:human genes:f:ftsj2|FTSJ2]]|0.592|
|[[:human genes:m:mrps6|MRPS6]]|0.591|
|[[:human genes:t:tars2|TARS2]]|0.591|
|[[:human genes:m:mrps5|MRPS5]]|0.591|
|[[:human genes:m:mrps26|MRPS26]]|0.587|
|[[:human genes:m:mrpl12|MRPL12]]|0.585|
|[[:human genes:m:mrps18a|MRPS18A]]|0.584|
|[[:human genes:d:dap3|DAP3]]|0.584|
|[[:human genes:n:ndufb11|NDUFB11]]|0.582|
|[[:human genes:l:lars2|LARS2]]|0.582|
|[[:human genes:m:mrpl23|MRPL23]]|0.581|
|[[:human genes:q:qrsl1|QRSL1]]|0.579|
|[[:human genes:m:mrps34|MRPS34]]|0.578|
|[[:human genes:v:vars2|VARS2]]|0.576|
|[[:human genes:n:ndufa3|NDUFA3]]|0.575|
|[[:human genes:m:mrps33|MRPS33]]|0.569|
|[[:human genes:m:mars2|MARS2]]|0.568|
|[[:human genes:m:mrp63|MRP63]]|0.565|
|[[:human genes:r:rars2|RARS2]]|0.564|
|[[:human genes:p:pnpt1|PNPT1]]|0.562|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.562|
|[[:human genes:m:mrpl47|MRPL47]]|0.562|
|[[:human genes:m:mterfd2|MTERFD2]]|0.556|
|[[:human genes:s:selrc1|SELRC1]]|0.554|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.552|
|[[:human genes:m:mrpl15|MRPL15]]|0.552|
|[[:human genes:p:pet112|PET112]]|0.549|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.549|
|[[:human genes:f:fastkd5|FASTKD5]]|0.547|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.545|
|[[:human genes:r:rbfa|RBFA]]|0.544|
|[[:human genes:p:pars2|PARS2]]|0.542|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.541|
|[[:human genes:m:mrpl20|MRPL20]]|0.54|
|[[:human genes:m:mrps9|MRPS9]]|0.535|
|[[:human genes:b:bcs1l|BCS1L]]|0.535|
|[[:human genes:p:pdss1|PDSS1]]|0.535|
|[[:human genes:s:sco2|SCO2]]|0.534|
|[[:human genes:a:atp5sl|ATP5SL]]|0.533|
|[[:human genes:n:ndufs7|NDUFS7]]|0.531|
|[[:human genes:s:sars2|SARS2]]|0.528|
|[[:human genes:c:cars2|CARS2]]|0.525|
|[[:human genes:w:wbscr16|WBSCR16]]|0.523|
|[[:human genes:c:c12orf65|C12orf65]]|0.523|
|[[:human genes:c:cox16|COX16]]|0.522|
|[[:human genes:p:polg|POLG]]|0.522|
|[[:human genes:m:mrps24|MRPS24]]|0.521|
|[[:human genes:m:mrps12|MRPS12]]|0.517|
|[[:human genes:m:mrpl55|MRPL55]]|0.516|
|[[:human genes:t:tufm|TUFM]]|0.515|
|[[:human genes:m:mrps10|MRPS10]]|0.507|
|[[:human genes:r:rpusd3|RPUSD3]]|0.507|
|[[:human genes:g:gfm2|GFM2]]|0.506|
|[[:human genes:n:ndufb3|NDUFB3]]|0.506|
|[[:human genes:u:uqcr10|UQCR10]]|0.501|
|[[:human genes:c:coq2|COQ2]]|0.5|
|[[:human genes:m:mrps2|MRPS2]]|0.498|
|[[:human genes:n:ndufa2|NDUFA2]]|0.498|
|[[:human genes:n:ndufc2|NDUFC2]]|0.497|
|[[:human genes:h:hars2|HARS2]]|0.496|
|[[:human genes:n:ndufs2|NDUFS2]]|0.495|
|[[:human genes:p:polg2|POLG2]]|0.495|
|[[:human genes:n:ndufa1|NDUFA1]]|0.493|
|[[:human genes:n:ndufv1|NDUFV1]]|0.491|
|[[:human genes:a:atp5a1|ATP5A1]]|0.491|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.49|
|[[:human genes:c:c17orf89|C17orf89]]|0.489|
|[[:human genes:a:atp5d|ATP5D]]|0.486|
|[[:human genes:m:mrpl45|MRPL45]]|0.482|
|[[:human genes:e:elac2|ELAC2]]|0.48|
|[[:human genes:m:mrps17|MRPS17]]|0.48|
|[[:human genes:a:aars2|AARS2]]|0.48|
|[[:human genes:m:mrpl3|MRPL3]]|0.48|
|[[:human genes:f:fars2|FARS2]]|0.477|
|[[:human genes:m:mrps25|MRPS25]]|0.476|
|[[:human genes:t:tmem242|TMEM242]]|0.475|
|[[:human genes:g:grsf1|GRSF1]]|0.474|
|[[:human genes:t:trub2|TRUB2]]|0.474|
|[[:human genes:m:mettl17|METTL17]]|0.473|
|[[:human genes:c:cox15|COX15]]|0.471|
|[[:human genes:n:ndufa11|NDUFA11]]|0.471|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.47|
|[[:human genes:m:mrpl41|MRPL41]]|0.47|
|[[:human genes:s:slc25a26|SLC25A26]]|0.468|
|[[:human genes:m:mtg2|MTG2]]|0.466|
|[[:human genes:n:ndufs5|NDUFS5]]|0.465|
|[[:human genes:t:tomm22|TOMM22]]|0.464|
|[[:human genes:c:coq3|COQ3]]|0.463|
|[[:human genes:m:mrps11|MRPS11]]|0.463|
|[[:human genes:n:ndufb5|NDUFB5]]|0.461|
|[[:human genes:w:wars2|WARS2]]|0.46|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.46|
|[[:human genes:m:mtg1|MTG1]]|0.46|
|[[:human genes:a:atp5b|ATP5B]]|0.459|
|[[:human genes:t:trmt10c|TRMT10C]]|0.459|
|[[:human genes:c:cox6c|COX6C]]|0.458|
|[[:human genes:p:polrmt|POLRMT]]|0.458|
|[[:human genes:c:coa6|COA6]]|0.457|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.456|
|[[:human genes:c:coq4|COQ4]]|0.455|
|[[:human genes:t:tfam|TFAM]]|0.454|
|[[:human genes:n:ndufb9|NDUFB9]]|0.454|
|[[:human genes:c:cox5a|COX5A]]|0.454|
|[[:human genes:c:cox11|COX11]]|0.453|
|[[:human genes:m:mrpl39|MRPL39]]|0.451|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.45|
|[[:human genes:t:tomm20|TOMM20]]|0.45|
|[[:human genes:m:mipep|MIPEP]]|0.45|
|[[:human genes:t:tmem261|TMEM261]]|0.449|
|[[:human genes:v:vps41|VPS41]]|0.448|
|[[:human genes:m:mrps23|MRPS23]]|0.447|
|[[:human genes:m:mrps7|MRPS7]]|0.445|
|[[:human genes:a:acad9|ACAD9]]|0.445|
|[[:human genes:c:cox20|COX20]]|0.443|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.443|
|[[:human genes:m:mtpap|MTPAP]]|0.443|
|[[:human genes:m:mtif3|MTIF3]]|0.442|
|[[:human genes:m:mrpl11|MRPL11]]|0.442|
|[[:human genes:m:mrpl44|MRPL44]]|0.441|
|[[:human genes:d:dhrsx|DHRSX]]|0.44|
|[[:human genes:h:hccs|HCCS]]|0.44|
|[[:human genes:e:ecsit|ECSIT]]|0.44|
|[[:human genes:a:alas1|ALAS1]]|0.44|
|[[:human genes:m:mrpl34|MRPL34]]|0.437|
|[[:human genes:m:mrpl43|MRPL43]]|0.436|
|[[:human genes:m:mrpl17|MRPL17]]|0.435|
|[[:human genes:m:minos1|MINOS1]]|0.435|
|[[:human genes:c:coq7|COQ7]]|0.435|
|[[:human genes:c:coa3|COA3]]|0.434|
|[[:human genes:m:mrpl42|MRPL42]]|0.434|
|[[:human genes:c:chchd4|CHCHD4]]|0.434|
|[[:human genes:t:tfb1m|TFB1M]]|0.433|
|[[:human genes:m:mrpl33|MRPL33]]|0.433|
|[[:human genes:o:opa1|OPA1]]|0.433|
|[[:human genes:m:mrpl35|MRPL35]]|0.43|
|[[:human genes:m:mrps22|MRPS22]]|0.429|
|[[:human genes:c:cox7b|COX7B]]|0.429|
|[[:human genes:t:tmem126b|TMEM126B]]|0.428|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.426|
|[[:human genes:n:ndufb6|NDUFB6]]|0.425|
|[[:human genes:m:mrpl18|MRPL18]]|0.424|
|[[:human genes:t:trmt10a|TRMT10A]]|0.422|
|[[:human genes:d:dhx30|DHX30]]|0.421|
|[[:human genes:a:atp5h|ATP5H]]|0.421|
|[[:human genes:f:fam195a|FAM195A]]|0.42|
|[[:human genes:k:kdsr|KDSR]]|0.418|
|[[:human genes:c:cox17|COX17]]|0.417|
|[[:human genes:m:mrpl52|MRPL52]]|0.416|
|[[:human genes:t:triap1|TRIAP1]]|0.415|
|[[:human genes:d:ddx28|DDX28]]|0.412|
|[[:human genes:a:atp5o|ATP5O]]|0.412|
|[[:human genes:g:glrx5|GLRX5]]|0.406|
|[[:human genes:n:ndufa8|NDUFA8]]|0.406|
|[[:human genes:a:atp5j|ATP5J]]|0.405|
|[[:human genes:n:ndufc1|NDUFC1]]|0.404|
|[[:human genes:r:rpia|RPIA]]|0.404|
|[[:human genes:m:mrpl13|MRPL13]]|0.403|
|[[:human genes:n:ndufs1|NDUFS1]]|0.402|
|[[:human genes:t:trmt61a|TRMT61A]]|0.402|
|[[:human genes:a:alg6|ALG6]]|0.402|
|[[:human genes:d:dohh|DOHH]]|0.402|
|[[:human genes:c:clpp|CLPP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2340
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TEFM Expression in NALM6 Cells: 4.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>