======= TENM4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TENM4
  * **<color #00a2e8>Official Name</color>**: teneurin transmembrane protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26011|26011]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6N022|Q6N022]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TENM4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TENM4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610084|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small- diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity). {ECO:0000250|UniProtKB:Q3UHK6, ECO:0000269|PubMed:26188006}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ten N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cardiac cell fate specification|
|central nervous system myelin formation|
|positive regulation of gastrulation|
|cardiac cell fate commitment|
|cardiac muscle cell proliferation|
|striated muscle cell proliferation|
|positive regulation of myelination|
|muscle cell proliferation|
|myelin assembly|
|central nervous system myelination|
|axon ensheathment in central nervous system|
|positive regulation of oligodendrocyte differentiation|
|cardiac muscle tissue growth|
|gastrulation with mouth forming second|
|heart growth|
|positive regulation of embryonic development|
|regulation of gastrulation|
|regulation of oligodendrocyte differentiation|
|regulation of myelination|
|oligodendrocyte development|
|positive regulation of glial cell differentiation|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|cell adhesion molecule binding|
|positive regulation of nervous system process|
|oligodendrocyte differentiation|
|regulation of glial cell differentiation|
|positive regulation of gliogenesis|
|cell fate specification|
|organ growth|
|cellular component assembly involved in morphogenesis|
|myelination|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|regulation of gliogenesis|
|cardiocyte differentiation|
|regulation of embryonic development|
|regulation of nervous system process|
|gastrulation|
|cardiac muscle tissue development|
|glial cell differentiation|
|gliogenesis|
|cell fate commitment|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|striated muscle tissue development|
|muscle tissue development|
|neuron projection|
|developmental growth|
|growth|
|positive regulation of neurogenesis|
|protein heterodimerization activity|
|cell-cell adhesion|
|heart development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell population proliferation|
|embryonic morphogenesis|
|regulation of system process|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|positive regulation of developmental process|
|integral component of plasma membrane|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6929
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TENM4 Expression in NALM6 Cells: 4.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>