======= TERF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TERF2
  * **<color #00a2e8>Official Name</color>**: telomeric repeat binding factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7014|7014]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15554|Q15554]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TERF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TERF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602027|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single- stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology- directed repair (HDR), which can affect telomere length. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:20655466, ECO:0000269|PubMed:9476899}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myb DNA-binding|
|TRF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of telomere single strand break repair|
|negative regulation of beta-galactosidase activity|
|negative regulation of single strand break repair|
|regulation of telomere maintenance via recombination|
|axonal transport of messenger ribonucleoprotein complex|
|anterograde axonal transport of messenger ribonucleoprotein complex|
|negative regulation of telomere maintenance via recombination|
|telomeric loop formation|
|negative regulation of exonuclease activity|
|regulation of telomeric D-loop disassembly|
|negative regulation of telomeric D-loop disassembly|
|regulation of DNA recombination at telomere|
|negative regulation of telomeric loop disassembly|
|regulation of telomere maintenance via semi-conservative replication|
|negative regulation of telomere maintenance via semi-conservative replication|
|negative regulation of DNA recombination at telomere|
|regulation of telomeric loop disassembly|
|regulation of single strand break repair|
|negative regulation of mitotic recombination|
|regulation of exonuclease activity|
|negative regulation of nuclear cell cycle DNA replication|
|negative regulation of t-circle formation|
|telomerase activity|
|regulation of mitotic recombination|
|protection from non-homologous end joining at telomere|
|Mre11 complex|
|shelterin complex|
|negative regulation of nuclease activity|
|regulation of t-circle formation|
|negative regulation of telomere capping|
|telomeric D-loop disassembly|
|protein localization to presynapse|
|nuclear telomere cap complex|
|anterograde axonal protein transport|
|double-stranded telomeric DNA binding|
|telomere maintenance in response to DNA damage|
|G-rich strand telomeric DNA binding|
|telomeric loop disassembly|
|axo-dendritic protein transport|
|protein localization to chromosome, telomeric region|
|regulation of nuclear cell cycle DNA replication|
|negative regulation of cellular senescence|
|telomere capping|
|negative regulation of telomere maintenance via telomerase|
|positive regulation of nitric-oxide synthase activity|
|regulation of nuclease activity|
|negative regulation of cell aging|
|negative regulation of DNA-dependent DNA replication|
|telomeric DNA binding|
|regulation of telomere capping|
|negative regulation of telomere maintenance via telomere lengthening|
|positive regulation of monooxygenase activity|
|cellular senescence|
|negative regulation of DNA repair|
|RNA-dependent DNA biosynthetic process|
|negative regulation of telomere maintenance|
|negative regulation of DNA biosynthetic process|
|negative regulation of DNA replication|
|regulation of cellular senescence|
|regulation of nitric-oxide synthase activity|
|anterograde axonal transport|
|negative regulation of DNA recombination|
|regulation of cell aging|
|chromosome, telomeric region|
|positive regulation of oxidoreductase activity|
|regulation of DNA-dependent DNA replication|
|regulation of telomere maintenance via telomerase|
|regulation of monooxygenase activity|
|axonal transport|
|axon cytoplasm|
|regulation of telomere maintenance via telomere lengthening|
|protein localization to chromosome|
|protein localization to synapse|
|cell aging|
|axo-dendritic transport|
|microtubule-based protein transport|
|protein transport along microtubule|
|negative regulation of response to DNA damage stimulus|
|regulation of telomere maintenance|
|regulation of oxidoreductase activity|
|telomere maintenance|
|telomere organization|
|regulation of DNA recombination|
|regulation of DNA replication|
|DNA biosynthetic process|
|nuclear chromosome, telomeric region|
|regulation of DNA biosynthetic process|
|negative regulation of DNA metabolic process|
|regulation of DNA repair|
|negative regulation of chromosome organization|
|transport along microtubule|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|protein C-terminus binding|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|regulation of response to DNA damage stimulus|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|protein-containing complex binding|
|microtubule-based movement|
|aging|
|nuclear body|
|negative regulation of cell cycle process|
|anatomical structure homeostasis|
|enzyme binding|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|negative regulation of hydrolase activity|
|negative regulation of cell cycle|
|microtubule-based process|
|negative regulation of cellular component organization|
|regulation of cellular response to stress|
|protein localization to organelle|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|protein homodimerization activity|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|intracellular protein transport|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|regulation of hydrolase activity|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.9|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.73|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.05|
|[[:results:exp73|LJH685 5μM R02 exp73]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmd11|PSMD11]]|0.524|
|[[:human genes:p:psmd1|PSMD1]]|0.511|
|[[:human genes:r:rps12|RPS12]]|0.502|
|[[:human genes:k:kctd17|KCTD17]]|0.502|
|[[:human genes:v:vasn|VASN]]|0.502|
|[[:human genes:t:terf1|TERF1]]|0.497|
|[[:human genes:p:psmc6|PSMC6]]|0.489|
|[[:human genes:h:hap1|HAP1]]|0.488|
|[[:human genes:g:gar1|GAR1]]|0.477|
|[[:human genes:t:tceb3c|TCEB3C]]|0.475|
|[[:human genes:z:zfand5|ZFAND5]]|0.468|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.467|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.466|
|[[:human genes:s:smg7|SMG7]]|0.461|
|[[:human genes:c:ciapin1|CIAPIN1]]|0.459|
|[[:human genes:p:psmd7|PSMD7]]|0.455|
|[[:human genes:r:rps14|RPS14]]|0.453|
|[[:human genes:p:pan3|PAN3]]|0.452|
|[[:human genes:u:ubap1|UBAP1]]|0.451|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.447|
|[[:human genes:c:cdc73|CDC73]]|0.446|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.444|
|[[:human genes:r:rps28|RPS28]]|0.442|
|[[:human genes:p:psmb1|PSMB1]]|0.441|
|[[:human genes:m:myo1h|MYO1H]]|0.44|
|[[:human genes:r:rps3a|RPS3A]]|0.438|
|[[:human genes:u:usp36|USP36]]|0.437|
|[[:human genes:m:mbtd1|MBTD1]]|0.435|
|[[:human genes:z:znf106|ZNF106]]|0.433|
|[[:human genes:p:ppm1d|PPM1D]]|0.432|
|[[:human genes:n:nup133|NUP133]]|0.432|
|[[:human genes:s:shpk|SHPK]]|0.432|
|[[:human genes:s:smg1|SMG1]]|0.432|
|[[:human genes:l:lrr1|LRR1]]|0.429|
|[[:human genes:w:wdr43|WDR43]]|0.429|
|[[:human genes:p:psma6|PSMA6]]|0.429|
|[[:human genes:i:iscu|ISCU]]|0.429|
|[[:human genes:m:mt1e|MT1E]]|0.428|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.428|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.428|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.427|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.427|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.426|
|[[:human genes:s:sf3a3|SF3A3]]|0.425|
|[[:human genes:t:top1mt|TOP1MT]]|0.425|
|[[:human genes:p:psmc2|PSMC2]]|0.423|
|[[:human genes:n:nol10|NOL10]]|0.422|
|[[:human genes:c:ccna2|CCNA2]]|0.421|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.421|
|[[:human genes:r:rpl30|RPL30]]|0.421|
|[[:human genes:t:twistnb|TWISTNB]]|0.42|
|[[:human genes:p:psmc1|PSMC1]]|0.419|
|[[:human genes:r:ranbp2|RANBP2]]|0.419|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.419|
|[[:human genes:o:orc1|ORC1]]|0.418|
|[[:human genes:p:psmb4|PSMB4]]|0.417|
|[[:human genes:c:ccdc94|CCDC94]]|0.417|
|[[:human genes:p:psmc5|PSMC5]]|0.416|
|[[:human genes:r:rps27a|RPS27A]]|0.415|
|[[:human genes:s:sfpq|SFPQ]]|0.415|
|[[:human genes:a:akirin2|AKIRIN2]]|0.415|
|[[:human genes:d:dtl|DTL]]|0.414|
|[[:human genes:x:xylt2|XYLT2]]|0.412|
|[[:human genes:n:nat14|NAT14]]|0.412|
|[[:human genes:t:taf1|TAF1]]|0.41|
|[[:human genes:h:hivep3|HIVEP3]]|0.41|
|[[:human genes:c:copa|COPA]]|0.41|
|[[:human genes:o:ogfr|OGFR]]|0.407|
|[[:human genes:p:pigs|PIGS]]|0.407|
|[[:human genes:s:sf3a1|SF3A1]]|0.406|
|[[:human genes:p:pan2|PAN2]]|0.405|
|[[:human genes:p:pcf11|PCF11]]|0.405|
|[[:human genes:n:narfl|NARFL]]|0.404|
|[[:human genes:z:znf830|ZNF830]]|0.404|
|[[:human genes:r:rpl35|RPL35]]|0.403|
|[[:human genes:r:rps2|RPS2]]|0.403|
|[[:human genes:a:adrm1|ADRM1]]|0.402|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.402|
|[[:human genes:c:casc3|CASC3]]|0.402|
|[[:human genes:e:exosc3|EXOSC3]]|0.402|
|[[:human genes:m:myh7b|MYH7B]]|0.401|
|[[:human genes:s:snip1|SNIP1]]|0.401|
|[[:human genes:c:cdc6|CDC6]]|0.4|
|[[:human genes:n:nop16|NOP16]]|0.4|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.4|
|[[:human genes:w:wdr87|WDR87]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 539/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|19/28|
|blood|24/28|
|bone|21/25|
|breast|24/33|
|central nervous system|42/56|
|cervix|3/4|
|colorectal|11/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|11/15|
|kidney|17/21|
|liver|16/20|
|lung|53/75|
|lymphocyte|10/14|
|ovary|20/26|
|pancreas|21/24|
|peripheral nervous system|15/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|3/7|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|18/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 502
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TERF2 Expression in NALM6 Cells: 6.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>