======= TGFB1I1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TGFB1I1
  * **<color #00a2e8>Official Name</color>**: transforming growth factor beta 1 induced transcript 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7041|7041]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43294|O43294]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TGFB1I1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TGFB1I1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602353|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Paxillin|
|LIM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin-dependent SMAD protein catabolic process|
|Roundabout binding|
|I-SMAD binding|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|androgen receptor signaling pathway|
|androgen receptor binding|
|negative regulation of fat cell differentiation|
|positive regulation of epithelial to mesenchymal transition|
|intracellular steroid hormone receptor signaling pathway|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|transcription coregulator activity|
|regulation of epithelial to mesenchymal transition|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|response to heat|
|nuclear matrix|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|steroid hormone mediated signaling pathway|
|regulation of fat cell differentiation|
|morphogenesis of embryonic epithelium|
|negative regulation of cellular response to growth factor stimulus|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|response to temperature stimulus|
|cellular response to steroid hormone stimulus|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cell fate commitment|
|regulation of cellular response to growth factor stimulus|
|transcription coactivator activity|
|response to steroid hormone|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|collagen-containing extracellular matrix|
|cytoskeleton|
|focal adhesion|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|transcription by RNA polymerase II|
|cellular response to lipid|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|cellular response to organic cyclic compound|
|modification-dependent macromolecule catabolic process|
|tissue morphogenesis|
|embryonic morphogenesis|
|proteolysis involved in cellular protein catabolic process|
|cellular response to hormone stimulus|
|cellular protein catabolic process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|protein catabolic process|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|response to lipid|
|cellular macromolecule catabolic process|
|response to hormone|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|embryo development|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|cell-cell signaling|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|proteolysis|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8209
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TGFB1I1 Expression in NALM6 Cells: 1.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>