======= THBS4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THBS4
  * **<color #00a2e8>Official Name</color>**: thrombospondin 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7060|7060]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35443|P35443]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THBS4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THBS4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600715|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity). {ECO:0000250, ECO:0000269|PubMed:19441079}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TSP C|
|COMP|
|EGF CA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endothelial cell-cell adhesion|
|myoblast migration|
|behavioral response to pain|
|epithelial cell-cell adhesion|
|muscle cell migration|
|positive regulation of neutrophil chemotaxis|
|positive regulation of granulocyte chemotaxis|
|regulation of neutrophil chemotaxis|
|positive regulation of neutrophil migration|
|response to pain|
|regulation of neutrophil migration|
|regulation of granulocyte chemotaxis|
|sarcoplasmic reticulum|
|multicellular organismal response to stress|
|regulation of tissue remodeling|
|positive regulation of cell division|
|basement membrane|
|positive regulation of leukocyte chemotaxis|
|positive regulation of endothelial cell proliferation|
|tissue remodeling|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|regulation of leukocyte chemotaxis|
|negative regulation of vasculature development|
|regulation of endothelial cell proliferation|
|positive regulation of leukocyte migration|
|integrin binding|
|positive regulation of chemotaxis|
|response to unfolded protein|
|growth factor activity|
|regulation of cell division|
|heparin binding|
|response to topologically incorrect protein|
|positive regulation of epithelial cell proliferation|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of leukocyte migration|
|regulation of chemotaxis|
|regulation of peptidyl-tyrosine phosphorylation|
|response to endoplasmic reticulum stress|
|regulation of angiogenesis|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|collagen-containing extracellular matrix|
|positive regulation of cell migration|
|cell-cell adhesion|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|behavior|
|positive regulation of response to external stimulus|
|calcium ion binding|
|regulation of cell migration|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|locomotion|
|regulation of protein phosphorylation|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of immune system process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.08|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.79|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.76|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.71|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.79|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.79|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.91|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.93|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.561|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5484
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THBS4 Expression in NALM6 Cells: 0.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>