======= THEMIS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THEMIS
  * **<color #00a2e8>Official Name</color>**: thymocyte selection associated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=387357|387357]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N1K5|Q8N1K5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THEMIS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THEMIS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613607|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CABIT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative T cell selection|
|positive T cell selection|
|COP9 signalosome|
|T cell selection|
|T cell differentiation|
|cell-cell junction|
|T cell receptor signaling pathway|
|T cell activation|
|lymphocyte differentiation|
|antigen receptor-mediated signaling pathway|
|leukocyte differentiation|
|lymphocyte activation|
|immune response-activating cell surface receptor signaling pathway|
|immune response-regulating cell surface receptor signaling pathway|
|hemopoiesis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|activation of immune response|
|immune system development|
|positive regulation of immune response|
|leukocyte activation|
|cell activation|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of immune system process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.51|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13186
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THEMIS Expression in NALM6 Cells: -1.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>