======= THNSL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THNSL2
  * **<color #00a2e8>Official Name</color>**: threonine synthase like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55258|55258]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86YJ6|Q86YJ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THNSL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THNSL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611261|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho- threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PALP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|threonine biosynthetic process|
|2-oxobutyrate biosynthetic process|
|threonine synthase activity|
|2-oxobutyrate metabolic process|
|short-chain fatty acid biosynthetic process|
|serine binding|
|threonine metabolic process|
|serine family amino acid catabolic process|
|short-chain fatty acid metabolic process|
|aspartate family amino acid biosynthetic process|
|serine family amino acid metabolic process|
|aspartate family amino acid metabolic process|
|pyridoxal phosphate binding|
|alpha-amino acid biosynthetic process|
|cellular amino acid biosynthetic process|
|alpha-amino acid catabolic process|
|fatty acid biosynthetic process|
|cellular amino acid catabolic process|
|cytokine activity|
|monocarboxylic acid biosynthetic process|
|alpha-amino acid metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|dephosphorylation|
|cellular amino acid metabolic process|
|fatty acid metabolic process|
|small molecule catabolic process|
|cellular component|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|molecular function|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|extracellular space|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.7|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11600
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THNSL2 Expression in NALM6 Cells: 1.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>