======= THRA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THRA
  * **<color #00a2e8>Official Name</color>**: thyroid hormone receptor alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7067|7067]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10827|P10827]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THRA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THRA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190120|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. {ECO:0000269|PubMed:12699376, ECO:0000269|PubMed:14673100, ECO:0000269|PubMed:18237438, ECO:0000269|PubMed:19926848}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C4|
|Hormone recep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|female courtship behavior|
|negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|
|courtship behavior|
|positive regulation of female receptivity|
|thyroid hormone mediated signaling pathway|
|regulation of thyroid hormone mediated signaling pathway|
|type I pneumocyte differentiation|
|negative regulation of transcription initiation from RNA polymerase II promoter|
|negative regulation of DNA-templated transcription, initiation|
|thyroid hormone binding|
|regulation of female receptivity|
|female mating behavior|
|regulation of RNA polymerase II transcriptional preinitiation complex assembly|
|lung epithelial cell differentiation|
|cartilage condensation|
|lung cell differentiation|
|cell aggregation|
|mating behavior|
|thyroid gland development|
|TBP-class protein binding|
|regulation of transcription initiation from RNA polymerase II promoter|
|regulation of myeloid cell apoptotic process|
|reproductive behavior|
|lung epithelium development|
|mating|
|regulation of DNA-templated transcription, initiation|
|nuclear receptor activity|
|response to cold|
|steroid hormone receptor activity|
|regulation of lipid catabolic process|
|nuclear receptor transcription coactivator activity|
|chromatin DNA binding|
|RNA polymerase II transcription factor complex|
|transcription regulatory region sequence-specific DNA binding|
|erythrocyte differentiation|
|erythrocyte homeostasis|
|positive regulation of cold-induced thermogenesis|
|myeloid cell homeostasis|
|steroid hormone mediated signaling pathway|
|endocrine system development|
|negative regulation of protein complex assembly|
|regulation of cold-induced thermogenesis|
|intracellular receptor signaling pathway|
|lung development|
|hormone-mediated signaling pathway|
|cartilage development|
|respiratory tube development|
|transcription initiation from RNA polymerase II promoter|
|response to temperature stimulus|
|cellular response to steroid hormone stimulus|
|respiratory system development|
|homeostasis of number of cells|
|signaling receptor activity|
|DNA-templated transcription, initiation|
|transcription regulatory region DNA binding|
|myeloid cell differentiation|
|connective tissue development|
|skeletal system morphogenesis|
|regulation of heart contraction|
|protein domain specific binding|
|learning or memory|
|ossification|
|protein-containing complex binding|
|regulation of blood circulation|
|cognition|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|response to steroid hormone|
|transcription factor binding|
|regulation of lipid metabolic process|
|gland development|
|regulation of protein complex assembly|
|transcription by RNA polymerase II|
|skeletal system development|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|hemopoiesis|
|behavior|
|regulation of system process|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|negative regulation of cellular component organization|
|brain development|
|head development|
|multicellular organismal reproductive process|
|sexual reproduction|
|zinc ion binding|
|multicellular organism reproduction|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|response to hormone|
|response to organic cyclic compound|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|central nervous system development|
|regulation of catabolic process|
|multi-organism reproductive process|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.92|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.92|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.78|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.78|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.74|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.74|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.76|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.76|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.79|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.8|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.82|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.83|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.04|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.08|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.12|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3278
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THRA Expression in NALM6 Cells: 4.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>