======= TIAL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIAL1
  * **<color #00a2e8>Official Name</color>**: TIA1 cytotoxic granule associated RNA binding protein like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7073|7073]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01085|Q01085]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIAL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIAL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603413|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA 3-UTR AU-rich region binding|
|stem cell division|
|cytoplasmic stress granule|
|fibroblast growth factor receptor signaling pathway|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|lysosome|
|germ cell development|
|cellular process involved in reproduction in multicellular organism|
|cell division|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|developmental process involved in reproduction|
|gamete generation|
|enzyme linked receptor protein signaling pathway|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|positive regulation of cell population proliferation|
|apoptotic process|
|multi-organism reproductive process|
|programmed cell death|
|cell death|
|cellular response to endogenous stimulus|
|defense response|
|RNA binding|
|reproductive process|
|reproduction|
|DNA binding|
|response to endogenous stimulus|
|regulation of cell population proliferation|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.59|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.14|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.1|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.09|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.98|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.87|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.86|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.81|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.75|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.75|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.7|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.74|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.75|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.77|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.82|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.84|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.95|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.1|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.27|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.36|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12969
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIAL1 Expression in NALM6 Cells: 7.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>