======= TICAM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TICAM1
  * **<color #00a2e8>Official Name</color>**: toll like receptor adaptor molecule 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=148022|148022]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IUC6|Q8IUC6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TICAM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TICAM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607601|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:14739303}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RHIM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of myeloid dendritic cell cytokine production|
|positive regulation of myeloid dendritic cell cytokine production|
|ripoptosome|
|positive regulation of dendritic cell cytokine production|
|negative regulation of MyD88-independent toll-like receptor signaling pathway|
|positive regulation of interferon-beta biosynthetic process|
|regulation of interferon-beta biosynthetic process|
|regulation of MyD88-independent toll-like receptor signaling pathway|
|cellular response to oxidised low-density lipoprotein particle stimulus|
|regulation of dendritic cell cytokine production|
|toll-like receptor 3 signaling pathway|
|positive regulation of chemokine biosynthetic process|
|macrophage activation involved in immune response|
|regulation of chemokine biosynthetic process|
|positive regulation of cytokine production involved in inflammatory response|
|positive regulation of myeloid leukocyte cytokine production involved in immune response|
|positive regulation of natural killer cell activation|
|regulation of protein homodimerization activity|
|necroptotic process|
|response to lipoprotein particle|
|programmed necrotic cell death|
|cellular response to lipoprotein particle stimulus|
|TRIF-dependent toll-like receptor signaling pathway|
|necrotic cell death|
|positive regulation of interferon-beta production|
|positive regulation of myeloid leukocyte mediated immunity|
|MyD88-independent toll-like receptor signaling pathway|
|regulation of natural killer cell activation|
|lipopolysaccharide-mediated signaling pathway|
|positive regulation of nitric oxide biosynthetic process|
|negative regulation of toll-like receptor signaling pathway|
|regulation of cytokine production involved in inflammatory response|
|positive regulation of nitric oxide metabolic process|
|positive regulation of B cell proliferation|
|response to exogenous dsRNA|
|regulation of interferon-beta production|
|macrophage activation|
|positive regulation of reactive oxygen species biosynthetic process|
|response to dsRNA|
|positive regulation of cytokine production involved in immune response|
|regulation of nitric oxide biosynthetic process|
|positive regulation of chemokine production|
|regulation of myeloid leukocyte mediated immunity|
|regulation of B cell proliferation|
|positive regulation of cytokine biosynthetic process|
|regulation of toll-like receptor signaling pathway|
|autophagosome|
|I-kappaB kinase/NF-kappaB signaling|
|positive regulation of type I interferon production|
|regulation of chemokine production|
|regulation of cytokine production involved in immune response|
|regulation of reactive oxygen species biosynthetic process|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of protein binding|
|positive regulation of interleukin-6 production|
|positive regulation of reactive oxygen species metabolic process|
|positive regulation of production of molecular mediator of immune response|
|toll-like receptor signaling pathway|
|regulation of cytokine biosynthetic process|
|positive regulation of protein ubiquitination|
|positive regulation of autophagy|
|regulation of type I interferon production|
|pattern recognition receptor signaling pathway|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|positive regulation of protein modification by small protein conjugation or removal|
|positive regulation of leukocyte proliferation|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|positive regulation of B cell activation|
|positive regulation of binding|
|regulation of reactive oxygen species metabolic process|
|cellular response to lipopolysaccharide|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to molecule of bacterial origin|
|defense response to virus|
|regulation of protein ubiquitination|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|endosome membrane|
|cellular response to biotic stimulus|
|positive regulation of immune effector process|
|regulation of protein binding|
|regulation of leukocyte proliferation|
|regulation of protein modification by small protein conjugation or removal|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|response to virus|
|apoptotic signaling pathway|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of autophagy|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|regulation of neurotransmitter levels|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|positive regulation of cellular catabolic process|
|regulation of binding|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of innate immune response|
|protein kinase binding|
|regulation of immune effector process|
|positive regulation of defense response|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell activation|
|response to bacterium|
|regulation of cytokine production|
|viral process|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|response to lipid|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|leukocyte activation|
|defense response to other organism|
|regulation of catabolic process|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|cell death|
|regulation of response to external stimulus|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|mitochondrion|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6583
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TICAM1 Expression in NALM6 Cells: 3.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>