======= TIMM17A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIMM17A
  * **<color #00a2e8>Official Name</color>**: translocase of inner mitochondrial membrane 17A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10440|10440]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99595|Q99595]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIMM17A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIMM17A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605057|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tim17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|
|TIM23 mitochondrial import inner membrane translocase complex|
|protein import into mitochondrial matrix|
|protein transmembrane transporter activity|
|positive regulation of protein processing|
|positive regulation of protein maturation|
|protein transmembrane import into intracellular organelle|
|integral component of mitochondrial inner membrane|
|intracellular protein transmembrane transport|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|regulation of protein processing|
|regulation of protein maturation|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|mitochondrial transmembrane transport|
|protein import|
|mitochondrial transport|
|positive regulation of proteolysis|
|protein targeting|
|mitochondrial inner membrane|
|establishment of protein localization to organelle|
|mitochondrion organization|
|regulation of proteolysis|
|protein localization to organelle|
|intracellular protein transport|
|mitochondrion|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of protein metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.72|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.7|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.74|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.75|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.77|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.77|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.78|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.9|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.95|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.97|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.98|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.99|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.01|
|[[:results:exp539|42°C R08 exp539]]|2.03|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.06|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.06|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.06|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.08|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.09|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.12|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.25|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.44|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.75|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|3.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:coq2|COQ2]]|0.497|
|[[:human genes:c:crls1|CRLS1]]|0.489|
|[[:human genes:p:pitrm1|PITRM1]]|0.482|
|[[:human genes:t:timm8b|TIMM8B]]|0.481|
|[[:human genes:r:rbfa|RBFA]]|0.48|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.476|
|[[:human genes:c:coq3|COQ3]]|0.476|
|[[:human genes:m:mrpl1|MRPL1]]|0.474|
|[[:human genes:g:glrx5|GLRX5]]|0.464|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.46|
|[[:human genes:m:mrpl21|MRPL21]]|0.458|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.457|
|[[:human genes:m:mrps6|MRPS6]]|0.452|
|[[:human genes:f:fastkd2|FASTKD2]]|0.447|
|[[:human genes:t:taz|TAZ]]|0.446|
|[[:human genes:r:rpusd4|RPUSD4]]|0.435|
|[[:human genes:p:pnpt1|PNPT1]]|0.425|
|[[:human genes:m:mrpl23|MRPL23]]|0.423|
|[[:human genes:m:mrpl45|MRPL45]]|0.422|
|[[:human genes:p:pet112|PET112]]|0.421|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.419|
|[[:human genes:a:alas1|ALAS1]]|0.417|
|[[:human genes:m:mrpl24|MRPL24]]|0.413|
|[[:human genes:m:mrpl44|MRPL44]]|0.409|
|[[:human genes:o:opa1|OPA1]]|0.409|
|[[:human genes:s:slc25a26|SLC25A26]]|0.408|
|[[:human genes:t:timm8a|TIMM8A]]|0.407|
|[[:human genes:c:c12orf65|C12orf65]]|0.406|
|[[:human genes:c:coq6|COQ6]]|0.403|
|[[:human genes:m:mrps21|MRPS21]]|0.403|
|[[:human genes:m:mrp63|MRP63]]|0.401|
|[[:human genes:f:ftsj2|FTSJ2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 30/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|6/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1457
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIMM17A Expression in NALM6 Cells: 6.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>