======= TIRAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIRAP
  * **<color #00a2e8>Official Name</color>**: TIR domain containing adaptor protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114609|114609]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P58753|P58753]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIRAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIRAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606252|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. {ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19509286}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of interleukin-15 production|
|TIRAP-dependent toll-like receptor 4 signaling pathway|
|regulation of interleukin-15 production|
|TIRAP-dependent toll-like receptor signaling pathway|
|regulation of chemokine (C-X-C motif) ligand 1 production|
|positive regulation of chemokine (C-X-C motif) ligand 1 production|
|Toll-like receptor 2 binding|
|Toll-like receptor 4 binding|
|positive regulation of toll-like receptor 2 signaling pathway|
|cellular response to bacterial lipoprotein|
|cellular response to bacterial lipopeptide|
|response to bacterial lipopeptide|
|response to bacterial lipoprotein|
|positive regulation of toll-like receptor 3 signaling pathway|
|positive regulation of toll-like receptor 4 signaling pathway|
|positive regulation of chemokine (C-X-C motif) ligand 2 production|
|regulation of toll-like receptor 3 signaling pathway|
|cellular response to lipoteichoic acid|
|response to lipoteichoic acid|
|regulation of toll-like receptor 2 signaling pathway|
|positive regulation of protein homodimerization activity|
|regulation of chemokine (C-X-C motif) ligand 2 production|
|positive regulation of interleukin-6 biosynthetic process|
|activation of NF-kappaB-inducing kinase activity|
|3-UTR-mediated mRNA stabilization|
|toll-like receptor 4 signaling pathway|
|regulation of toll-like receptor 4 signaling pathway|
|regulation of protein homodimerization activity|
|positive regulation of toll-like receptor signaling pathway|
|regulation of interleukin-6 biosynthetic process|
|positive regulation of neutrophil chemotaxis|
|positive regulation of granulocyte chemotaxis|
|positive regulation of neutrophil migration|
|regulation of neutrophil chemotaxis|
|MyD88-dependent toll-like receptor signaling pathway|
|positive regulation of interleukin-12 production|
|regulation of neutrophil migration|
|positive regulation of B cell proliferation|
|mRNA stabilization|
|regulation of granulocyte chemotaxis|
|regulation of interferon-beta production|
|RNA stabilization|
|positive regulation of interleukin-8 production|
|negative regulation of mRNA catabolic process|
|protein kinase C binding|
|regulation of interleukin-12 production|
|positive regulation of chemokine production|
|endocytic vesicle|
|negative regulation of RNA catabolic process|
|regulation of B cell proliferation|
|positive regulation of cytokine biosynthetic process|
|regulation of toll-like receptor signaling pathway|
|regulation of interleukin-8 production|
|phosphatidylinositol-4,5-bisphosphate binding|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of chemokine production|
|negative regulation of mRNA metabolic process|
|protein binding, bridging|
|NIK/NF-kappaB signaling|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of leukocyte chemotaxis|
|defense response to Gram-positive bacterium|
|positive regulation of protein binding|
|positive regulation of interleukin-6 production|
|ruffle membrane|
|toll-like receptor signaling pathway|
|regulation of cytokine biosynthetic process|
|regulation of NIK/NF-kappaB signaling|
|regulation of leukocyte chemotaxis|
|regulation of type I interferon production|
|pattern recognition receptor signaling pathway|
|positive regulation of leukocyte migration|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of chemotaxis|
|positive regulation of leukocyte proliferation|
|positive regulation of JNK cascade|
|regulation of interleukin-6 production|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|positive regulation of B cell activation|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|positive regulation of binding|
|regulation of mRNA stability|
|regulation of RNA stability|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of JNK cascade|
|cellular response to molecule of bacterial origin|
|regulation of leukocyte migration|
|regulation of mRNA catabolic process|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|cellular response to biotic stimulus|
|regulation of protein binding|
|myeloid cell differentiation|
|regulation of leukocyte proliferation|
|regulation of stress-activated MAPK cascade|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of cellular catabolic process|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|regulation of ERK1 and ERK2 cascade|
|negative regulation of catabolic process|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|activation of protein kinase activity|
|regulation of mRNA metabolic process|
|defense response to bacterium|
|positive regulation of innate immune response|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|regulation of binding|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of DNA-binding transcription factor activity|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of defense response|
|protein heterodimerization activity|
|inflammatory response|
|positive regulation of cell migration|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|hemopoiesis|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|activation of immune response|
|regulation of cell activation|
|immune system development|
|positive regulation of transferase activity|
|response to bacterium|
|regulation of cytokine production|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|defense response to other organism|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of catabolic process|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|regulation of response to external stimulus|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5912
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIRAP Expression in NALM6 Cells: 2.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>