======= TLR7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TLR7
  * **<color #00a2e8>Official Name</color>**: toll like receptor 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51284|51284]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYK1|Q9NYK1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TLR7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TLR7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300365|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). {ECO:0000250, ECO:0000269|PubMed:18250417}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIR|
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of interferon-alpha biosynthetic process|
|toll-like receptor 7 signaling pathway|
|regulation of interferon-alpha biosynthetic process|
|positive regulation of interferon-beta biosynthetic process|
|regulation of interferon-beta biosynthetic process|
|signaling pattern recognition receptor activity|
|early phagosome|
|siRNA binding|
|positive regulation of interleukin-8 biosynthetic process|
|I-kappaB phosphorylation|
|positive regulation of interferon-gamma biosynthetic process|
|endolysosome membrane|
|toll-like receptor 9 signaling pathway|
|regulation of interleukin-8 biosynthetic process|
|regulation of interferon-gamma biosynthetic process|
|positive regulation of interferon-alpha production|
|regulation of interferon-alpha production|
|positive regulation of interferon-beta production|
|microglial cell activation|
|leukocyte activation involved in inflammatory response|
|MyD88-dependent toll-like receptor signaling pathway|
|glial cell activation|
|neuroinflammatory response|
|single-stranded RNA binding|
|regulation of interferon-beta production|
|positive regulation of interleukin-8 production|
|macrophage activation|
|positive regulation of chemokine production|
|drug binding|
|positive regulation of interferon-gamma production|
|positive regulation of cytokine biosynthetic process|
|regulation of interleukin-8 production|
|I-kappaB kinase/NF-kappaB signaling|
|double-stranded RNA binding|
|positive regulation of NIK/NF-kappaB signaling|
|positive regulation of type I interferon production|
|regulation of chemokine production|
|cellular response to mechanical stimulus|
|positive regulation of interleukin-6 production|
|regulation of interferon-gamma production|
|toll-like receptor signaling pathway|
|regulation of cytokine biosynthetic process|
|regulation of NIK/NF-kappaB signaling|
|regulation of type I interferon production|
|pattern recognition receptor signaling pathway|
|transmembrane signaling receptor activity|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|defense response to virus|
|receptor complex|
|endosome membrane|
|response to mechanical stimulus|
|innate immune response-activating signal transduction|
|lysosome|
|activation of innate immune response|
|endosome|
|response to virus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|cellular response to external stimulus|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of defense response|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|Golgi membrane|
|activation of immune response|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|positive regulation of immune response|
|leukocyte activation|
|endoplasmic reticulum membrane|
|defense response to other organism|
|protein phosphorylation|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-2.26|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.25|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.14|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.05|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.85|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.81|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.74|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.74|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17380
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.72 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TLR7 Expression in NALM6 Cells: 1.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>