======= TMBIM6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMBIM6
  * **<color #00a2e8>Official Name</color>**: transmembrane BAX inhibitor motif containing 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7009|7009]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55061|P55061]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMBIM6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMBIM6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600748|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity). {ECO:0000250|UniProtKB:Q9D2C7, ECO:0000269|PubMed:21075086, ECO:0000269|PubMed:22128171}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bax1-I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of endoribonuclease activity|
|endoribonuclease inhibitor activity|
|negative regulation of ribonuclease activity|
|negative regulation of immunoglobulin secretion|
|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|
|regulation of endoribonuclease activity|
|regulation of hypoxia-induced intrinsic apoptotic signaling pathway|
|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|
|negative regulation of cellular response to hypoxia|
|negative regulation of nuclease activity|
|regulation of ribonuclease activity|
|response to L-glutamate|
|negative regulation of immunoglobulin production|
|negative regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of cellular response to hypoxia|
|negative regulation of calcium ion transport into cytosol|
|regulation of immunoglobulin secretion|
|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|regulation of nuclease activity|
|endoplasmic reticulum calcium ion homeostasis|
|negative regulation of RNA splicing|
|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|
|negative regulation of production of molecular mediator of immune response|
|negative regulation of response to endoplasmic reticulum stress|
|negative regulation of calcium ion transport|
|regulation of immunoglobulin production|
|regulation of response to endoplasmic reticulum stress|
|negative regulation of intrinsic apoptotic signaling pathway|
|regulation of calcium ion transport into cytosol|
|mitochondrial membrane|
|negative regulation of protein binding|
|response to amino acid|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|negative regulation of immune effector process|
|regulation of DNA-templated transcription in response to stress|
|cellular response to unfolded protein|
|negative regulation of protein secretion|
|regulation of RNA splicing|
|negative regulation of peptide secretion|
|regulation of production of molecular mediator of immune response|
|negative regulation of ion transport|
|cellular response to topologically incorrect protein|
|intrinsic apoptotic signaling pathway|
|regulation of intrinsic apoptotic signaling pathway|
|response to unfolded protein|
|negative regulation of binding|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|response to topologically incorrect protein|
|negative regulation of secretion by cell|
|response to nutrient|
|regulation of protein binding|
|negative regulation of apoptotic signaling pathway|
|negative regulation of secretion|
|regulation of calcium ion transport|
|response to endoplasmic reticulum stress|
|process utilizing autophagic mechanism|
|autophagy|
|apoptotic signaling pathway|
|ubiquitin protein ligase binding|
|response to acid chemical|
|enzyme binding|
|regulation of binding|
|regulation of metal ion transport|
|regulation of apoptotic signaling pathway|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|calcium ion homeostasis|
|negative regulation of hydrolase activity|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|regulation of immune effector process|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|response to nutrient levels|
|negative regulation of intracellular signal transduction|
|response to extracellular stimulus|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of ion transport|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of secretion|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|apoptotic process|
|endoplasmic reticulum membrane|
|negative regulation of cell death|
|response to organonitrogen compound|
|endoplasmic reticulum|
|response to drug|
|regulation of protein localization|
|programmed cell death|
|response to nitrogen compound|
|cell death|
|chemical homeostasis|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14751
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMBIM6 Expression in NALM6 Cells: 8.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>