======= TMEM161A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM161A
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 161A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54929|54929]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NX61|Q9NX61]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM161A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM161A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618966|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. {ECO:0000269|PubMed:16551573}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tmemb 161AB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|positive regulation of DNA repair|
|negative regulation of response to DNA damage stimulus|
|cellular response to UV|
|negative regulation of intrinsic apoptotic signaling pathway|
|positive regulation of response to DNA damage stimulus|
|response to retinoic acid|
|cellular response to light stimulus|
|regulation of DNA repair|
|response to UV|
|regulation of intrinsic apoptotic signaling pathway|
|cellular response to radiation|
|positive regulation of DNA metabolic process|
|regulation of response to DNA damage stimulus|
|negative regulation of apoptotic signaling pathway|
|cellular response to oxidative stress|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|response to acid chemical|
|regulation of DNA metabolic process|
|response to oxidative stress|
|regulation of apoptotic signaling pathway|
|response to radiation|
|negative regulation of intracellular signal transduction|
|regulation of cellular response to stress|
|response to lipid|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|response to abiotic stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|cellular response to stress|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.77|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.55|
|[[:human genes:p:polr2j3|POLR2J3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3100
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM161A Expression in NALM6 Cells: 5.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>