======= TMEM30A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM30A
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 30A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55754|55754]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NV96|Q9NV96]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM30A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM30A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611028|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet- activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations. {ECO:0000269|PubMed:20510206, ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:20961850, ECO:0000269|PubMed:21289302}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CDC50|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aminophospholipid flippase activity|
|aminophospholipid translocation|
|aminophospholipid transport|
|protein localization to endosome|
|positive regulation of protein exit from endoplasmic reticulum|
|ATPase-coupled intramembrane lipid transporter activity|
|regulation of protein exit from endoplasmic reticulum|
|transport vesicle membrane|
|phospholipid translocation|
|lipid translocation|
|regulation of membrane lipid distribution|
|azurophil granule membrane|
|drug transmembrane transport|
|phospholipid transport|
|specific granule membrane|
|organophosphate ester transport|
|drug transport|
|positive regulation of intracellular protein transport|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|positive regulation of neuron projection development|
|lipid transport|
|apical plasma membrane|
|lipid localization|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|positive regulation of protein transport|
|organic anion transport|
|positive regulation of establishment of protein localization|
|positive regulation of neurogenesis|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of neuron projection development|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|anion transport|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulated exocytosis|
|regulation of protein transport|
|regulation of cell projection organization|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|leukocyte mediated immunity|
|exocytosis|
|regulation of neurogenesis|
|membrane organization|
|regulation of cellular localization|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|positive regulation of cell differentiation|
|Golgi apparatus|
|positive regulation of transport|
|secretion by cell|
|endoplasmic reticulum|
|response to drug|
|regulation of protein localization|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|positive regulation of cellular component organization|
|transmembrane transport|
|positive regulation of developmental process|
|ion transport|
|generation of neurons|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-4.05|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-3.62|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-3.28|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-3.18|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-3.12|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-3.1|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-3.07|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-3.02|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.95|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.9|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.82|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.79|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.74|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.68|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.61|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.46|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.43|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-2.41|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.35|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.29|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.26|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.17|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-2.11|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.1|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.08|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-2.05|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.04|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.04|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-2|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.94|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.92|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.9|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.89|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.88|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.87|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.85|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.84|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.84|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.83|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.81|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.81|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.79|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.77|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.73|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.71|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.85|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.12|
|[[:results:exp518|RK-33 8μM R08 exp518]]|2.46|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.65|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|3.15|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|4.45|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|4.89|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|5.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp8b2|ATP8B2]]|0.513|
|[[:human genes:t:tmem230|TMEM230]]|0.477|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14386
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM30A Expression in NALM6 Cells: 6.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>